ChemicalBook > CAS DataBase List > Exherin (trifluoroacetate)

Exherin (trifluoroacetate)

Product Name: Exherin (trifluoroacetate)
CAS No.: 1135237-88-5
Chemical Name: Exherin (trifluoroacetate)
Synonyms: ADH-1 trifluroacetate;ADH-1 TRIFLUOROACETATE;Exherin (trifluoroacetate);ADH-1 trifluoroacetate, 10 mM in DMSO;ADH 1,ADH1 trifluoroacetate,Inhibitor,ADH1,ADH-1,inhibit,ADH 1 trifluoroacetate
CBNumber: CB42735520
Molecular Formula: C24H35F3N8O8S2
Formula Weight: 684.7087096
MOL File: 1135237-88-5.mol

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Exherin (trifluoroacetate) Property

storage temp.: Store at -20°C
solubility: DMSO:43.0(Max Conc. mg/mL);62.8(Max Conc. mM)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Crysdot

Product number: CD31004502
Product name: Exherintrifluoroacetate
Purity: 98+%
Packaging: 5mg
Price: $76
Updated: 2021/12/16

Crysdot

Product number: CD31004502
Product name: Exherintrifluoroacetate
Purity: 98+%
Packaging: 10mg
Price: $125
Updated: 2021/12/16

Crysdot

Product number: CD31004502
Product name: Exherintrifluoroacetate
Purity: 98+%
Packaging: 50mg
Price: $312
Updated: 2021/12/16

DC Chemicals

Product number: DC9532
Product name: Exherin(trifluoroacetate)
Purity: >98%
Packaging: 100mg
Price: $400
Updated: 2021/12/16

Crysdot

Product number: CD31004502
Product name: Exherintrifluoroacetate
Purity: 98+%
Packaging: 100mg
Price: $520
Updated: 2021/12/16

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Exherin (trifluoroacetate) Chemical Properties,Usage,Production

Uses

ADH-1 trifluoroacetate is an N-cadherin antagonist, which inhibits N-cadherin mediated cell adhesion.

in vivo

ADH-1 (50 mg/kg) significantly prevents tumor growth and metastasis in a mouse model for pancreatic cancer. ADH-1 prevents tumor cell invasion and metastasis in an orthotopic model for pancreatic cancer using N-cadherin overexpressing BxPC-3 cells^[1]. ADH-1, at the dosages evaluated, does not display either antiangiogenic activity in a rat aortic ring assay or antitumor potential in a PC3 subcutaneous xenograft tumor model^[2]. ADH-1 (10 mL/kg, i.p.) augmentation of melanoma tumor growth is overcome through its ability to make regionally infused melphalan more effective. ADH-1 mediated augmentation of melanoma tumor growth is not altered by regionally infused temozolomide. In A375, but not DM443 xenografts, ADH-1 treatment increases phosphorylation of AKT at serine 473. ADH-1 slightly diminishes N-cadherin expression in both xenografts^[3].

References

[1] Shintani Y, et al. ADH-1 suppresses N-cadherin-dependent pancreatic cancer progression. Int J Cancer. 2008 Jan 1;122(1):71-7. DOI:10.1002/ijc.23027
[2] Li H, et al. ADH1, an N-cadherin inhibitor, evaluated in preclinical models of angiogenesis and androgen-independent prostate cancer. Anticancer Drugs. 2007 Jun;18(5):563-8. DOI:10.1097/CAD.0b013e328020043e
[3] Turley RS, et al. Targeting N-cadherin increases vascular permeability and differentially activates AKT in melanoma. Ann Surg. 2015 Feb;261(2):368-77 DOI:10.1097/SLA.0000000000000635

Exherin (trifluoroacetate) Preparation Products And Raw materials

Raw materials

Preparation Products

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1135237-88-5, Exherin (trifluoroacetate)Related Search:

ADH-1 TRIFLUOROACETATE

Exherin (trifluoroacetate)

ADH-1 trifluroacetate

ADH 1,ADH1 trifluoroacetate,Inhibitor,ADH1,ADH-1,inhibit,ADH 1 trifluoroacetate

ADH-1 trifluoroacetate, 10 mM in DMSO

1135237-88-5

C24H35F3N8O8S2