Taltobulin (trifluoroacetate)

Product Name: Taltobulin (trifluoroacetate)
CAS No.: 228266-41-9
Chemical Name: Taltobulin (trifluoroacetate)
Synonyms: SPA-110 trifluoroacetate;HTI-286 trifluoroacetate;Taltobulin (trifluoroacetate);HTI-286 TRIFLUOROACETATE;SPA-110 TRIFLUOROACETATE
CBNumber: CB42735540
Molecular Formula: C29H44F3N3O6
Formula Weight: 587.6713696
MOL File: 228266-41-9.mol

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Taltobulin (trifluoroacetate) Property

storage temp.: Store at -20°C
solubility: DMSO : ≥ 39 mg/mL (66.36 mM)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-3787
Product name: Taltobulin(trifluoroacetate)
Purity: 99.96%
Packaging: 5mg
Price: $220
Updated: 2021/12/16

ChemScene

Product number: CS-3787
Product name: Taltobulin(trifluoroacetate)
Purity: 99.96%
Packaging: 10mg
Price: $340
Updated: 2021/12/16

ChemScene

Product number: CS-3787
Product name: Taltobulin(trifluoroacetate)
Purity: 99.96%
Packaging: 50mg
Price: $950
Updated: 2021/12/16

Crysdot

Product number: CD31002592
Product name: Taltobulintrifluoroacetate
Purity: 98+%
Packaging: 5mg
Price: $216
Updated: 2021/12/16

Crysdot

Product number: CD31002592
Product name: Taltobulintrifluoroacetate
Purity: 98+%
Packaging: 50mg
Price: $910
Updated: 2021/12/16

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Taltobulin (trifluoroacetate) Chemical Properties,Usage,Production

Uses

Taltobulin trifluoroacetate (HTI-286 trifluoroacetate), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin trifluoroacetate inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis[1].

in vivo

Taltobulin (HTI-286; 1.6 mg/kg i.v.) inhibits the growth of human tumor xenografts (e.g., HCT-15, DLD-1, MX-1W, and KB-8-5) in athymic nu/nu female mice^[1].
Taltobulin (HTI-286; 3 mg/kg; p.o. gavage) inhibits growth by 97.3 % and 82% in athymic nu/nu female mice with Lox melanoma xenografts and KB-3-1 epidermoid xenograft model, respectively^[1].

Animal Model:	Athymic nu/nu female mice with Lox melanoma model (5-6 weeks of age)^[1]
Dosage:	1.6 mg/kg
Administration:	Administered i.v.;for 35 days
Result:	Growth of Lox tumors was inhibited by 96-98% on day 12 compared with vehicle-treated controls. Growth of KB-8-5 tumors was inhibited by 84% on day 14 compared with vehicle-treated controls. Growth of MX-1W tumors was inhibited by 97% compared with vehicle-treated controls. Growth of DLD-1 and HCT-15 tumors was inhibited by 80 and 66%, respectively.

IC 50

Traditional Cytotoxic Agents

References

[1] Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63(8):1838-45. PMID:12702571

Taltobulin (trifluoroacetate) Preparation Products And Raw materials

Raw materials

Preparation Products

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Taltobulin (trifluoroacetate) Suppliers

China 23 United States 4 USA 1 Global 28

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View Lastest Price from Taltobulin (trifluoroacetate) manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Taltobulin trifluoroacetate 228266-41-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Taltobulin trifluoroacetate 228266-41-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

228266-41-9, Taltobulin (trifluoroacetate)Related Search:

HTI-286 trifluoroacetate

HTI-286 TRIFLUOROACETATE;SPA-110 TRIFLUOROACETATE

SPA-110 trifluoroacetate

Taltobulin (trifluoroacetate)

228266-41-9