3-(Benzyloxy)benzene-1,2-diaMine
- Product Name
- 3-(Benzyloxy)benzene-1,2-diaMine
- CAS No.
- 89521-55-1
- Chemical Name
- 3-(Benzyloxy)benzene-1,2-diaMine
- Synonyms
- 3-(Benzyloxy)benzene-1,2-diaMine;1,2-Benzenediamine, 3-(phenylmethoxy)-
- CBNumber
- CB42735823
- Molecular Formula
- C13H14N2O
- Formula Weight
- 214.26
- MOL File
- 89521-55-1.mol
3-(Benzyloxy)benzene-1,2-diaMine Property
- Boiling point:
- 402.4±30.0 °C(Predicted)
- Density
- 1.199±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 4.33±0.10(Predicted)
- Appearance
- Brown to black Powder
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CM126122
- Product name
- 3-(benzyloxy)benzene-1,2-diamine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $337
- Updated
- 2021/12/16
- Product number
- CD12014264
- Product name
- 3-(Benzyloxy)benzene-1,2-diamine
- Purity
- 98%
- Packaging
- 1g
- Price
- $356
- Updated
- 2021/12/16
- Product number
- 61-10775
- Product name
- 3-(Benzyloxy)benzene-1,2-diamine
- Purity
- 95-98%
- Packaging
- 1g
- Price
- $370
- Updated
- 2021/12/16
- Product number
- CM126122
- Product name
- 3-(benzyloxy)benzene-1,2-diamine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $1010
- Updated
- 2021/12/16
- Product number
- CD12014264
- Product name
- 3-(Benzyloxy)benzene-1,2-diamine
- Purity
- 98%
- Packaging
- 5g
- Price
- $1070
- Updated
- 2021/12/16
3-(Benzyloxy)benzene-1,2-diaMine Chemical Properties,Usage,Production
Synthesis
89521-54-0
89521-55-1
Under nitrogen protection, 2-(benzyloxy)-6-nitroaniline (5 g, 0.02 mol) was dissolved in a mixed solution of acetic acid (50 mL) and ethanol (50 mL) and stirred at 15 °C. To this solution was added iron powder (4.6 g, 0.08 mol). The reaction mixture was heated to 75°C and stirred continuously for 30 minutes. After completion of the reaction, the mixture was concentrated under vacuum. The concentrated residue was dissolved in water (50 mL) and the pH was adjusted with saturated sodium bicarbonate solution to 9. Subsequently, the aqueous phase was extracted with ethyl acetate (50 mL x 3). The organic phases were combined, washed with brine (50 mL), dried over anhydrous sodium sulfate, and concentrated under vacuum. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate) to give 3-(benzyloxy)benzene-1,2-diamine (2.2 g, 77.7% yield) as a yellow oil.LCMS (M+H+) m/z: calculated value 215.12; measured value 215.1.
References
[1] Patent: WO2016/200840, 2016, A1. Location in patent: Page/Page column 405; 406
[2] Journal of Medicinal Chemistry, 2018, vol. 61, # 8, p. 3309 - 3324
[3] Archives of Pharmacal Research, 2017, vol. 40, # 4, p. 469 - 479
[4] Journal of Heterocyclic Chemistry, 1983, vol. 20, # 6, p. 1525 - 1532
[5] Patent: WO2009/24825, 2009, A1. Location in patent: Page/Page column 132
3-(Benzyloxy)benzene-1,2-diaMine Preparation Products And Raw materials
Raw materials
Preparation Products
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