CAS:932749-62-7
- Product Name
- CAS:932749-62-7
- CAS No.
- 932749-62-7
- Chemical Name
- CAS:932749-62-7
- Synonyms
- CAS:932749-62-7;HAT Inhibitor II;Histone Acetyltransferase Inhibitor II;Histone Acetyltransferase Inhibitor II (compound 2c);Histone Acetyltransferase Inhibitor II, 10 mM in DMSO;2,6-Bis(3-bromo-4-hydroxybenzylidene)cyclohexan-1-one;2,6-Bis[(3-bromo-4-hydroxyphenyl)methylene]cyclohexanone;Cyclohexanone, 2,6-bis[(3-bromo-4-hydroxyphenyl)methylene]-;Histone Acetyltransferase Inhibitor II, p300/CBP HAT inhibitor;(2E,6E)-2,6-bis[(3-bromo-4-hydroxyphenyl)methylidene]cyclohexan-1-one
- CBNumber
- CB42741611
- Molecular Formula
- C20H16Br2O3
- Formula Weight
- 464.15
- MOL File
- 932749-62-7.mol
CAS:932749-62-7 Property
- Melting point:
- 201-202 °C(Solv: isopropanol (67-63-0); water (7732-18-5))
- Boiling point:
- 580.8±50.0 °C(Predicted)
- Density
- 1.733±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≤20mg/ml in ethanol;30mg/ml in DMSO;50mg/ml in dimethyl formamide
- form
- crystalline solid
- pka
- 7.89±0.35(Predicted)
- color
- Light yellow to yellow
- InChI
- InChI=1S/C20H16Br2O3/c21-16-10-12(4-6-18(16)23)8-14-2-1-3-15(20(14)25)9-13-5-7-19(24)17(22)11-13/h4-11,23-24H,1-3H2
- InChIKey
- YOLKEKNTCBWPSD-UHFFFAOYSA-N
- SMILES
- C1(=O)C(=CC2=CC=C(O)C(Br)=C2)CCCC1=CC1=CC=C(O)C(Br)=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 19835
- Product name
- HAT Inhibitor II
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 19835
- Product name
- HAT Inhibitor II
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 19835
- Product name
- HAT Inhibitor II
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $213
- Updated
- 2024/03/01
- Product number
- 451941
- Product name
- Histone Acetyltransferase Inhibitor II
- Packaging
- 10mg
- Price
- $516
- Updated
- 2021/12/16
- Product number
- H456345
- Product name
- HistoneAcetyltransferaseInhibitorII
- Packaging
- 25mg
- Price
- $400
- Updated
- 2021/12/16
CAS:932749-62-7 Chemical Properties,Usage,Production
Uses
Histone Acetyltransferase Inhibitor II is a selective, cell-permeable p300/CBP HAT inhibitor, which may be used in the treatement of cystic fibrosis.
Biological Activity
hat inhibitor ii, a cell-permeable bis-arylidene cyclohexanone compound, selectively inhibits the histone acetyltransferase p300/creb-binding protein (cbp) with an ic50 value of 5 μm. it affects gcn5 and pcaf acetyltransferases only at much higher concentrations.histone acetyltransferase p300, a ubiquitously expressed global transcriptional coactivator, plays critical roles in a wide variety of cellular phenomena, involving in cell cycle control, differentiation, and apoptosis.
in vitro
hat inhibitor ii dose-dependently suppressed the proliferation of u251, u87, hs683 and shg44 cells. in hat inhibitor ii-treated u251 and shg44 cells, cell cycle arrest at the g2/m phase was triggered by hat inhibitor ii, significant levels of apoptosis, apoptotic body formation and dna fragmentation were induced, and cleavage of caspase-3, caspase-9 and parp were caused. additionally, hat inhibitor ii upregulated 965 genes and downregulated 984 genes in hat inhibitor ii-treated u251 cells [1].
in vivo
c57bl/6j mice were intraperitoneally administrated with hat inhibitor ii at a dose of 185 μg/g for 15 min. in muscle early postmortem, hat inhibitor ii inhibited protein acetylation, which reduced amp-activated protein kinase activation induced increase in the total acetylated proteins as well as glycolytic rate [2].
IC 50
CBP/p300
References
[1]. xu, l., li, z., tao, y., li, r., fang, f., & zhao, h. et al. histone acetyltransferase inhibitor ii induces apoptosis in glioma cell lines via the p53 signaling pathway. journal of experimental & clinical cancer research. 2014; 33:108.
[2]. li, q., li, z., lou, a., wang, z., zhang, d., & shen, q. histone acetyltransferase inhibitors antagonize amp-activated protein kinase in postmortem glycolysis. asian-australasian journal of animal sciences. 2016; 30(6): 857-864.
CAS:932749-62-7 Preparation Products And Raw materials
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