Methyl 2-amino-5-fluoro-3-nitrobenzoate
- Product Name
- Methyl 2-amino-5-fluoro-3-nitrobenzoate
- CAS No.
- 328547-11-1
- Chemical Name
- Methyl 2-amino-5-fluoro-3-nitrobenzoate
- Synonyms
- Methyl 2-amino-5-fluoro-3-nitrobenzoate;Benzoic acid, 2-amino-5-fluoro-3-nitro-, methyl ester
- CBNumber
- CB42750172
- Molecular Formula
- C8H7FN2O4
- Formula Weight
- 214.15
- MOL File
- 328547-11-1.mol
Methyl 2-amino-5-fluoro-3-nitrobenzoate Property
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- M289275
- Product name
- methyl2-amino-5-fluoro-3-nitrobenzoate
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M289275
- Product name
- methyl2-amino-5-fluoro-3-nitrobenzoate
- Packaging
- 250mg
- Price
- $285
- Updated
- 2021/12/16
- Product number
- HCH0369141
- Product name
- METHYL-2-AMINO-5-FLUORO-3-NITROBENZOATE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $332.85
- Updated
- 2021/12/16
- Product number
- 3712AB
- Product name
- Methyl2-amino-5-fluoro-3-nitrobenzoate
- Packaging
- 100mg
- Price
- $151
- Updated
- 2021/12/16
- Product number
- BB20-7219
- Product name
- 2-Amino-5-fluoro-3-nitro-benzoicacidmethylester
- Purity
- ＞97%
- Packaging
- 1g
- Price
- $395
- Updated
- 2021/12/16
Methyl 2-amino-5-fluoro-3-nitrobenzoate Chemical Properties,Usage,Production
Synthesis
67-56-1
954571-39-2
328547-11-1
Step 1. 5-Fluoro-7-nitroindoline-2,3-dione (1.5 g, 7.4 mmol) was suspended in aqueous NaOH (5N, 14.0 mL) followed by addition of aqueous H2O2 (2.0 mL). The reaction mixture was stirred at room temperature for 5 h and then acidified with 2N HCl to pH=4.0. The resulting precipitate was filtered and dried in a vacuum oven to give a crude product which was used directly in the next step of the reaction. Step 2. The crude product obtained from Step 1 was dissolved in methanol (15.0 mL) and p-toluenesulfonic acid hydrate (1.33 g, 7.0 mmol) was added. The reaction mixture was refluxed for 36 hours. After cooling to room temperature, the reaction mixture was concentrated in vacuum to obtain the crude product. The crude product was purified by silica gel column chromatography with petroleum ether/ethyl acetate (8:1, v/v) as eluent to give the yellow solid product methyl 2-amino-5-fluoro-3-nitrobenzoate (500 mg, 32% overall yield in two steps).
References
[1] European Journal of Medicinal Chemistry, 2018, vol. 145, p. 389 - 403
Methyl 2-amino-5-fluoro-3-nitrobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 2-amino-5-fluoro-3-nitrobenzoate Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from Methyl 2-amino-5-fluoro-3-nitrobenzoate manufacturers
- Product
- methyl 2-amino-5-fluoro-3-nitrobenzoate 328547-11-1
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-26