1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole

Product Name: 1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole
CAS No.: 337506-43-1
Chemical Name: 1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole
Synonyms: BIM5078;BIM5078 Exclusive;BIM5078 >=98% (HPLC);1-(2-chloro-5-nitrophenyl)sulfonyl-2-methylbenzimidazole;1-(2′-Chloro-5′-nitrobenzenesulfonyl)-2-methylbenzimidazole;1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole;1H-Benzimidazole, 1-[(2-chloro-5-nitrophenyl)sulfonyl]-2-methyl-
CBNumber: CB42751063
Molecular Formula: C14H10ClN3O4S
Formula Weight: 351.76
MOL File: 337506-43-1.mol

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1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole Property

Boiling point:: 573.1±60.0 °C(Predicted)
Density: 1.58±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble10mg/mL, clear (warmed)
pka: 0.49±0.10(Predicted)
form: powder
color: white to beige
InChI: 1S/C14H10ClN3O4S/c1-9-16-12-4-2-3-5-13(12)17(9)23(21,22)14-8-10(18(19)20)6-7-11(14)15/h2-8H,1H3
InChIKey: DLUVMRPVZILBOE-UHFFFAOYSA-N
SMILES: CC1=NC2=CC=CC=C2N1S(C3=C(Cl)C=CC([N+]([O-])=O)=C3)(=O)=O

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
Storage Class: 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications: Acute Tox. 3 Oral

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0528
Product name: BIM5078
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $154
Updated: 2026/03/19

Sigma-Aldrich

Product number: SML0528
Product name: BIM5078
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $591
Updated: 2026/03/19

Cayman Chemical

Product number: 12031
Product name: BIM5078
Purity: ≥98%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 12031
Product name: BIM5078
Purity: ≥98%
Packaging: 10mg
Price: $115
Updated: 2024/03/01

Cayman Chemical

Product number: 12031
Product name: BIM5078
Purity: ≥98%
Packaging: 25mg
Price: $270
Updated: 2024/03/01

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1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole Chemical Properties,Usage,Production

Description

HNF4α is a nuclear receptor transcription factor that controls the expression of many genes including those involved in glucose and lipid homeostasis and maintenance of epithelial differentiation. BIM5078 is an HNF4α antagonist that can repress the expression of known HNF4α target genes, inhibiting endogenous insulin expression in T6PNE cells with an IC₅₀ value of 930 nM. BIM5078 binds directly to the ligand binding pocket of HNF4α with an EC₅₀ value of 11.9 nM. However, BIM5078 has unfavorable pharmacokinetic properties including low plasma and microsomal stability (8% remaining after 3 hours and 32% after 1.25 hours, respectively), high binding to plasma proteins (98% bound after 4 hours), and low solubility (0.17 mg/ml after 18 hours). BI6015 is a structural analog of BIM5078 developed for more favorable pharmacokinetics.

Uses

BIM5078 is a hepatocyte nuclear factor 4α (HNF4α) antagonist that can inhibit the expression of known HNF4α target genes. BIM5078 represses insulin promoter activity through HNF4α antagonism. BIM5078 can be used for the research of cancer and diabetes[1].

References

[1] Kiselyuk A, et al. HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter. Chem Biol. 2012 Jul 27;19(7):806-18. DOI:10.1016/j.chembiol.2012.05.014

1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole Suppliers

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337506-43-1, 1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazoleRelated Search:

1-(2′-Chloro-5′-nitrobenzenesulfonyl)-2-methylbenzimidazole

1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole

BIM5078

BIM5078 Exclusive

1-(2-chloro-5-nitrophenyl)sulfonyl-2-methylbenzimidazole

1H-Benzimidazole, 1-[(2-chloro-5-nitrophenyl)sulfonyl]-2-methyl-

BIM5078 >=98% (HPLC)

337506-43-1