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tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate

Product Name
tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate
CAS No.
336191-17-4
Chemical Name
tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate
Synonyms
TERT-BUTYL 2,8-DIAZASPIRO[4.5]DECANE-2-CARBOXYLATE;2-Boc-2,8-diaza-spiro[4.5...;2-Boc-2,8-Diaza-spiro[4.5]decane;2-N-Boc-2,8-diaza-spiro[4.5]decane;2,8-Diazaspiro[4.5]decane, N2-BOC protected;2-Boc-2,8-diazaspiro[4.5]decane hemioxalate;tert-Butyl 2,8-diazaspiro4.5decan-2-carboxylate;ert-Butyl2,8-diazaspiro[4.5]decane-2-carboxylate;tert-Butyl 3,8-diazaspiro[4.5]decane-3-carboxylate;tert-Butyl2,7-diazaspiro[4,5]decane-2-carboxylate,98%
CBNumber
CB4275734
Molecular Formula
C13H24N2O2
Formula Weight
240.34
MOL File
336191-17-4.mol
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tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate Property

Boiling point:
337.0±35.0 °C(Predicted)
Density 
1.07±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
10.97±0.20(Predicted)
form 
solid
color 
Off-white to grey
InChI
InChI=1S/C13H24N2O2/c1-12(2,3)17-11(16)15-9-6-13(10-15)4-7-14-8-5-13/h14H,4-10H2,1-3H3
InChIKey
NFNCPNAVNRBDOU-UHFFFAOYSA-N
SMILES
C1C2(CCNCC2)CCN1C(OC(C)(C)C)=O
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Safety

Risk Statements 
20-22-36/37/38
Safety Statements 
26-36
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D417595
Product name
2,8-Diaza-spiro[4.5]decane-2-carboxylicAcidtert-ButylEster
Packaging
25mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD56508
Product name
2,8-Diaza-spiro[4·5]decane-2-carboxylic acid tert-butyl ester
Packaging
50mg
Price
$65
Updated
2021/12/16
Synthonix
Product number
D6099
Product name
2,8-Diazaspiro[4.5]decane-2-carboxylicacidtert-butylester
Purity
97.0%
Packaging
500mg
Price
$65
Updated
2021/12/16
Apolloscientific
Product number
OR16902
Product name
2,8-Diazaspiro[4.5]decane,N2-BOCprotected
Packaging
250mg
Price
$80
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-94
Product name
tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate
Purity
95%
Packaging
250mg
Price
$88
Updated
2021/12/16
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tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate Chemical Properties,Usage,Production

Chemical Properties

Wihte powder

Uses

tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate is a heterocyclic derivative and can be used as a pharmaceutical synthesis intermediate.

Synthesis

929301-98-4

336191-17-4

Preparation of Compound 6: Compound 5 (2,8-diazaspiro[4.5]decane-2,8-dicarboxylic acid, 2-(1,1-dimethylethyl)8-(phenylmethyl) ester, 30 g, 0.08 mol) was dissolved in methanol (100 mL), and hydrogenation reaction was carried out by adding 20% Pd(OH)2/C catalyst (5 g) at room temperature and under hydrogen pressure of 76 cmHg. until the reaction was complete. After completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated. The resulting residue was purified by column chromatography to afford the target product compound 6 (tert-butyl 2,8-diazaspiro[4.5]deca-2-carboxylate, 11 g, 57% yield).1H NMR (DMSO, HCl salt) δ: 8.88 (broad peak, 2H), 3.28-3.23 (multiple peaks, 2H), 3.10 (double peaks, 2H), 2.99 (triple peaks, 2H) , 1.68-1.61 (multiple peaks, 2H), 1.63-1.59 (multiple peaks, 4H), 1.36 (single peak, 9H).

References

[1] Patent: WO2007/30061, 2007, A1. Location in patent: Page/Page column 88; 89

tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate Suppliers

China 129 India 1 United Kingdom 3 United States 20 Global 153
Shanghai Wenjia Biomedical Technology Co., Ltd.
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15001899038 15001899038;
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wenjiayiyao@126.com
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China
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Ningbo yirui biology science and technology co., ltd
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15221000252
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J & K SCIENTIFIC LTD.
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Energy Chemical
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Nanjing Chemlin Chemical Co., Ltd
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025-83697070
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SpringPharma Tech Co.,Ltd
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Shanghai Sunway Pharmaceutical Technology Co., Ltd
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Baiyin Chengze Chemical Technology Co., Ltd.
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+86-943-8535351
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sales@chengzechem.com
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China
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Shanghai Topbiochem Technology Co., Ltd
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021-58170097
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China
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Shanghai T&W Pharmaceutical Co., Ltd.
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+86 21 61551611
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+86 21 50676805
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China
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View Lastest Price from tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
2-Boc-2,8-Diazaspiro[4.5]decane 336191-17-4
Price
US $2.00-6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-08-05
Career Henan Chemical Co
Product
2,8-DIAZA-SPIRO[4.5]DECANE-2-CARBOXYLIC ACID TERT-BUTYL ESTER 336191-17-4
Price
US $6.60/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2019-12-25

336191-17-4, tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylateRelated Search:

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  • 2,8-DIAZA-SPIRO[4.5]DECANE-2-CARBOXYLIC ACID TERT-BUTYL ESTER
  • TERT-BUTYL 2,8-DIAZASPIRO[4.5]DECANE-2-CARBOXYLATE
  • tert-Butyl2,7-diazaspiro[4,5]decane-2-carboxylate,98%
  • 2-Boc-2,8-diaza-spiro[4.5...
  • 2,8-Diazaspiro[4.5]decane, N2-BOC protected
  • 2-Boc-2,8-Diaza-spiro[4.5]decane
  • 2,8-Diaza-Spiro[4.5]Decane-2-Carboxylic acid Tert-Butyl Es
  • 2,8-Diazaspiro[4.5]decane-2-carboxylic acid, 1,1-diMethylethyl ester
  • 2,8-Diazaspiro[4.5]decane-2-carboxylic acid tert-butyl ester - D6099
  • 2-Boc-2,8-diazaspiro[4.5]decane hemioxalate
  • tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate, 2-(tert-Butoxycarbonyl)-2,8-diazaspiro[4.5]decane
  • 2-N-Boc-2,8-diaza-spiro[4.5]decane
  • tert-Butyl 3,8-diazaspiro[4.5]decane-3-carboxylate
  • ert-Butyl2,8-diazaspiro[4.5]decane-2-carboxylate
  • 1,1-Dimethylethyl 2,8-diazaspiro[4.5]decane-2-carboxylate
  • tert-Butyl 2,8-diazaspiro4.5decan-2-carboxylate
  • 2,8-Diazaspiro[4,5]decane-2-carboxylate tert-butyl ester
  • 336191-17-4
  • C13H24N2O205C2H2O4