ChemicalBook > CAS DataBase List > 3-AMINO-BENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER

3-AMINO-BENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER

Product Name
3-AMINO-BENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER
CAS No.
57805-85-3
Chemical Name
3-AMINO-BENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER
Synonyms
METHYL 3-AMINOBENZOFURAN-2-CARBOXYLATE;methyl 3-amino-2-benzofurancarboxylate;Methyl3-aminobenzo[b]furan-2-carboxylate;methyl3-amino-2-benzofurancarboxylate;METHYL 3-AMINO-1-BENZOFURAN-2-CARBOXYLATE;3-AMINO-BENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER;2-Benzofurancarboxylic acid, 3-amino-, methyl ester
CBNumber
CB4277006
Molecular Formula
C10H9NO3
Formula Weight
191.18
MOL File
57805-85-3.mol
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3-AMINO-BENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER Property

Melting point:
82-84 °C(Solv: benzene (71-43-2))
Boiling point:
317.5±22.0 °C(Predicted)
Density 
1.304±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
solid
pka
0.41±0.10(Predicted)
Appearance
Off-white to light yellow Solid
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Safety

Hazard Codes 
Xn
Risk Statements 
22
HS Code 
2922390090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
BBO000501
Product name
Methyl 3-aminobenzofuran-2-carboxylate
Packaging
1 g
Price
$216
Updated
2025/07/31
Sigma-Aldrich
Product number
T302449
Product name
4-CHLORO-BENZOFURO[3,2-D]PYRIMIDINE
Purity
AldrichCPR
Packaging
5MG
Price
$148
Updated
2025/07/31
TRC
Product number
M331635
Product name
Methyl3-Amino-2-benzo[b]furancarboxylate
Packaging
500mg
Price
$155
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA146863
Product name
3-Amino-benzofuran-2-carboxylic acid methylester
Packaging
10mg
Price
$183
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA146863
Product name
3-Amino-benzofuran-2-carboxylic acid methylester
Packaging
25mg
Price
$366
Updated
2021/12/16
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3-AMINO-BENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER Chemical Properties,Usage,Production

Synthesis

34844-79-6

57805-85-3

The general procedure for the synthesis of methyl 3-aminobenzofuran-2-carboxylate from the compound (CAS: 34844-79-6) was as follows: compound 2 (2.62 g, 13.9 mmol, 1.00 eq.) was dissolved in dry ether and transferred to an argon protected flask. Subsequently, potassium tert-butoxide (0.78 g, 6.9 mmol, 0.50 eq.) was slowly added and the reaction mixture was stirred at room temperature for 25 minutes. Upon completion of the reaction, the reaction was quenched by the addition of a small amount of water and the solvent was subsequently removed by evaporation. The residue was dissolved in water (30 mL) and extracted with diethyl ether (30 mL × 3). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and the solvent was evaporated to give a light yellow crystalline product in 65% yield with a melting point of 94 °C. The product was characterized by 1H-NMR: δ=7.55 (d, J=7.9 Hz, 1H, H4), 7.48-7.41 (m, 2H, H7 and H6), 7.19-7.30 (m, 1H, H5), 5.00 (br s, 2H, NH2), 3.96 (s, 3H, COOCH3).13C-NMR data: δ=162.1 ( COOCH3), 154.3 (C7a), 138.9 (C3), 129.1 (C4), 125.6 (C3a), 122.5 (C5), 121.8 (C2), 119.8 (C6), 112.8 (C7), 51.7 (COOCH3). Results of mass spectrometry (EI, 70 eV) analysis: measured value 191 (calculated value for C10H9NO3: 191.19); m/z (% relative abundance) = 191 (M+, 100), 159 (50), 133 (25), 103 (90), 83 (20), 77 (50), 51 (25).

References

[1] Molecules, 2016, vol. 21, # 2,
[2] Journal of Medicinal Chemistry, 1999, vol. 42, # 26, p. 5464 - 5474
[3] Patent: US5679683, 1997, A

3-AMINO-BENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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3-AMINO-BENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER Suppliers

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57805-85-3, 3-AMINO-BENZOFURAN-2-CARBOXYLIC ACID METHYL ESTERRelated Search:

METHYL 3-(1H-PYRROL-1-YL)-1-BENZOFURAN-2-CARBOXYLATE 3-AMINO-5-CHLORO-BENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER (E)-4-([2-(METHOXYCARBONYL)-1-BENZOFURAN-3-YL]AMINO)-4-OXO-2-BUTENOIC ACID METHYL 3-(2,5-DIOXO-2,5-DIHYDRO-1H-PYRROL-1-YL)-1-BENZOFURAN-2-CARBOXYLATE ETHYL 3-[(CHLOROACETYL)AMINO]-1-BENZOFURAN-2-CARBOXYLATE METHYL 3-(1,3-DIHYDRO-2H-ISOINDOL-2-YL)-1-BENZOFURAN-2-CARBOXYLATE ETHYL 3-AMINOBENZOFURAN-2-CARBOXYLATE METHYL 3-([(E)-(DIMETHYLAMINO)METHYLIDENE]AMINO)-1-BENZOFURAN-2-CARBOXYLATE 3-AMINO-5-BROMO-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER 3-AMINO-5-CHLORO-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER METHYL 3-[BIS(PHENOXYCARBONYL)AMINO]-1-BENZOFURAN-2-CARBOXYLATE 3-AMINO-BENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER

  • 3-AMINO-BENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER
  • METHYL 3-AMINO-1-BENZOFURAN-2-CARBOXYLATE
  • methyl 3-amino-2-benzofurancarboxylate
  • 2-Benzofurancarboxylic acid, 3-amino-, methyl ester
  • METHYL 3-AMINOBENZOFURAN-2-CARBOXYLATE
  • methyl3-amino-2-benzo<b>furancarboxylate
  • Methyl3-aminobenzo[b]furan-2-carboxylate
  • 57805-85-3