Description
ChemicalBook > CAS DataBase List > SR 202

SR 202

Description
Product Name
SR 202
CAS No.
76541-72-5
Chemical Name
SR 202
Synonyms
SR 202;MIFOBATE;Clenicor;claniclor;SR-202 >=98% (HPLC), crystalline;Dimethyl (α-dimethoxyphosphinyl-p-chlorobenzyl) phosphate;DIMETHYL (ALPHA-DIMETHOXYPHOSPHINYL-P-CHLOROBENZYL) PHOSPHATE;(4-Chlorophenyl)(dimethoxyphosphoryl)methyl dimethyl phosphate;[(4-Chlorophenyl)(dimethoxyphosphinyl)methyl]dimethyl=phosphate;Dimethyl (α-dimethoxyphosphinyl-p-chlorobenzyl) phosphate, Mifobate
CBNumber
CB4285085
Molecular Formula
C11H17ClO7P2
Formula Weight
358.65
MOL File
76541-72-5.mol
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SR 202 Property

Boiling point:
436.6±45.0 °C(Predicted)
Density 
1.355±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO: 5 mg/mL
form 
crystalline
color 
white
Water Solubility 
Soluble to 100 mM in water
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Safety

Safety Statements 
22-24/25
WGK Germany 
2
RTECS 
TB8817000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21846
Product name
SR 202
Purity
≥95%
Packaging
1mg
Price
$45
Updated
2024/03/01
Cayman Chemical
Product number
21846
Product name
SR 202
Purity
≥95%
Packaging
5mg
Price
$133
Updated
2024/03/01
Tocris
Product number
2022
Product name
SR202
Purity
≥99%(HPLC)
Packaging
10
Price
$151
Updated
2021/12/16
Tocris
Product number
2022
Product name
SR202
Purity
≥99%(HPLC)
Packaging
50
Price
$616
Updated
2021/12/16
Usbiological
Product number
256741
Product name
SR 202
Packaging
10mg
Price
$389
Updated
2021/12/16
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SR 202 Chemical Properties,Usage,Production

Description

SR 202 is an effective and specific PPARγ antagonist that selectively inhibits the transcriptional activity of PPARγ induced by TZD (IC50=140 μM). Sr-202 does not affect basal or ligand stimulated transcriptional activity of PPARα, PPARβ, or FXR. It has anti-obesity and anti-diabetes effects.

Uses

Anti-atherosclerotic.

Uses

SR 202 is a noniodinated, potential lipid-altering agent and an inhibitor of the peripheral conversion of T4 to T3 associated with thyroid hormone metabolism.

Definition

ChEBI: Phosphoric acid [(4-chlorophenyl)-dimethoxyphosphorylmethyl] dimethyl ester is a trialkyl phosphate.

brand name

Clenicor (Symphar S.A.,Switzerland).

Biological Activity

Selective PPAR γ antagonist; antidiabetic and antiobesity agent. Attenuates troglitazone-induced PPAR γ transcriptional activity (IC 50 = 140 μ M) without affecting ligand-stimulated PPAR α , PPAR β or FXR transcriptional activity. Inhibits PPAR γ -dependent adipocyte differentiation and growth in vitro and in vivo . Improves insulin sensitivity in diabetic ob/ob mice and increases HDL levels in rats in vivo .

in vitro

sr-202 is a specific antagonist of ppar, which shows selectivity both among the ppar family members and other nuclear receptors. sr-202 also inhibits ppar-dependent differentiation of adipocytes. in cell culture, sr-202 efficiently antagonizes hormone- and tzd induced adipocyte differentiation [1].

in vivo

. decreasing ppar activity by treatment with sr-202 leads to a reduction of both high fat diet-induced adipocyte hypertrophy and insulin resistance. treatment with sr-202 also dramatically improves insulin sensitivity in the diabetic ob/ob mice [1]. when wild-type mice are fed a high-fat diet, the plasma levels of tnf-α are raised, and sr-202 treatment protects against this rise [2]..

IC 50

140 μm for attenuation of troglitazone-induced peroxisome proliferator-activated receptor gamma (ppar) transcriptional activity [1]

storage

Desiccate at RT

References

[1] rieusset j, touri f, michalik l, escher p, desvergne b, niesor e, wahli w. a new selective peroxisome proliferator-activated receptor gamma antagonist with antiobesity and antidiabetic activity. mol endocrinol. 2002 nov;16(11):2628-44.
[2] doggrell s. do peroxisome proliferation receptor-gamma antagonists have clinical potential as combined antiobesity and antidiabetic drugs expert opin investig drugs. 2003 apr;12(4):713-6.

SR 202 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR 202 Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Shanghai Synchem Pharma Co., ltd
Tel
21-619849051-1 18521059765
Email
synchempharma@aliyun.com
Country
China
ProdList
6463
Advantage
55
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
4966
Advantage
55
Aikon International Limited
Tel
025-58851090 13611564524
Fax
(6)02557626880
Email
lwan@aikonchem.com
Country
China
ProdList
15951
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
Advantage
58
Zhengzhou Edward Biology Co.,Ltd
Tel
0371-63682289 15538176268
Fax
QQ:1875164801
Email
jacschem@163.com
Country
China
ProdList
9989
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58

76541-72-5, SR 202Related Search:


  • DIMETHYL (ALPHA-DIMETHOXYPHOSPHINYL-P-CHLOROBENZYL) PHOSPHATE
  • (4-CHLOROPHENYL)(DIMETHOXYPHOSPHINYL)METHYL PHOSPHORIC ACID DIMETHYL ESTER
  • SR 202
  • MIFOBATE
  • claniclor
  • phosphoricacid,(4-chlorophenyl)(dimethoxyphosphinyl)methyldimethylester
  • [(4-Chlorophenyl)(dimethoxyphosphinyl)methyl]dimethyl=phosphate
  • Clenicor
  • Dimethyl (α-dimethoxyphosphinyl-p-chlorobenzyl) phosphate
  • Dimethyl (α-dimethoxyphosphinyl-p-chlorobenzyl) phosphate, Mifobate
  • SR-202 >=98% (HPLC), crystalline
  • (4-Chlorophenyl)(dimethoxyphosphoryl)methyl dimethyl phosphate
  • SR 202,diabetes,Peroxisome proliferator-activated receptors,adipocyte,stimulation,antiobesity,transcriptional,type 2,obesity,differentiation,PPAR,activity,selective,Mifobate,antidiabetic,inhibit,Inhibitor,SR202
  • 76541-72-5
  • 6541-72-5
  • C11H17ClO7P2
  • Intracellular receptor