2-[4-(4-NITROPHENYL)PIPERAZINO]-1-ETHANOL

Product Name: 2-[4-(4-NITROPHENYL)PIPERAZINO]-1-ETHANOL
CAS No.: 5521-38-0
Chemical Name: 2-[4-(4-NITROPHENYL)PIPERAZINO]-1-ETHANOL
Synonyms: 2-(4-(4-Nitrophenyl);1-Piperazineethanol, 4-(4-nitrophenyl)-;2-[4-(4-NITROPHENYL)PIPERAZINO]-1-ETHANOL;2-[4-(4-NITROPHENYL)PIPERAZIN-1-YL]ETHANOL;2-[4-(4-Nitrophenyl)-1-piperazinyl]ethanol;2-[4-(4-Nitrophenyl)-1-piperazinyl]ethanol,97%;2-[4-(4-Nitrophenyl)-1-piperazinyl]ethanol, 97%
CBNumber: CB4286062
Molecular Formula: C12H17N3O3
Formula Weight: 251.28
MOL File: 5521-38-0.mol

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2-[4-(4-NITROPHENYL)PIPERAZINO]-1-ETHANOL Property

Melting point:: 97-99°C
Boiling point:: 445.6±45.0 °C(Predicted)
Density: 1.258±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 14.96±0.10(Predicted)
form: Solid

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

TRC

Product number: N545298
Product name: 2-(4-(4-Nitrophenyl)piperazin-1-yl)ethanol
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: N545298
Product name: 2-(4-(4-Nitrophenyl)piperazin-1-yl)ethanol
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 044509
Product name: 2-[4-(4-Nitrophenyl)piperazino]-1-ethanol
Purity: >95%
Packaging: 500mg
Price: $39
Updated: 2021/12/16

Matrix Scientific

Product number: 044509
Product name: 2-[4-(4-Nitrophenyl)piperazino]-1-ethanol
Purity: >95%
Packaging: 1g
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 044509
Product name: 2-[4-(4-Nitrophenyl)piperazino]-1-ethanol
Purity: >95%
Packaging: 5g
Price: $200
Updated: 2021/12/16

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2-[4-(4-NITROPHENYL)PIPERAZINO]-1-ETHANOL Chemical Properties,Usage,Production

Synthesis

103-76-4

350-46-9

5521-38-0

To a stirred suspension of anhydrous dimethyl sulfoxide (10 mL) of 1-fluoro-4-nitrobenzene (2 g, 14.17 mmol) and potassium carbonate (3.92 g, 28.3 mmol) was slowly added 2-(piperazin-1-yl)ethanol (2.089 mL, 17.01 mmol). The reaction mixture was heated and stirred at 80°C for 16 hours. After completion of the reaction, it was cooled to room temperature and the mixture was poured into water (100 mL) and extracted with ethyl acetate (30 mL). The aqueous layer was separated and a second extraction was performed with ethyl acetate (2 x 30 mL). All organic phases were combined and concentrated under reduced pressure to remove the solvent. The concentrated residue was ground in water (100 mL) to precipitate a solid. The solid product was collected by vacuum filtration and dried under vacuum with a stream of nitrogen for 16 h to afford the target compound 2-[4-(4-nitrophenyl)piperazine]-1-ethanol (3.45 g, 97% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 8.11 (d, 2H), 6.82 (d, 2H), 3.68 (t, 2H), 3.44 (t, 4H), 2.67 (t, 4H), 2.62 (t, 2H), 2.55 (br s, 1H).Results of the analysis by LCMS (Method C): retention time (RT) = 0.45 min, m/z = 252 [M + H]+.

References

[1] Patent: WO2015/92431, 2015, A1. Location in patent: Page/Page column 236
[2] Patent: WO2015/27222, 2015, A2. Location in patent: Paragraph 0322
[3] Patent: WO2012/59932, 2012, A1. Location in patent: Page/Page column 112-113
[4] Patent: WO2016/138527, 2016, A1. Location in patent: Paragraph 00212
[5] Journal of Medicinal Chemistry, 2005, vol. 48, # 7, p. 2371 - 2387

2-[4-(4-NITROPHENYL)PIPERAZINO]-1-ETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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