Methyl L-tryptophanate hydrochloride
- Product Name
- Methyl L-tryptophanate hydrochloride
- CAS No.
- 7524-52-9
- Chemical Name
- Methyl L-tryptophanate hydrochloride
- Synonyms
- L-TRYPTOPHAN METHYL ESTER HYDROCHLORIDE;H-Trp-Ome;H-TRP-OME·HCL;(S)-Methyl 2-aMino-3-(1H-indol-3-yl)propanoate hydrochloride;Trp-Ome.HCl;H-Trp-OMe·HC;H-TRP-OME HCL;L-Trp-OMe.HCL;H-L-Trp-OMe*HCl;TRYPTOPHAN-OME HCL
- CBNumber
- CB4292113
- Molecular Formula
- C12H15ClN2O2
- Formula Weight
- 254.71
- MOL File
- 7524-52-9.mol
Methyl L-tryptophanate hydrochloride Property
- Melting point:
- 218-220 °C(lit.)
- alpha
- 18 º (c=5 CH3OH)
- refractive index
- 19.5 ° (C=5, MeOH)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Sparingly)
- form
- Powder
- color
- White to off-white
- optical activity
- [α]20/D +18°, c = 5 in methanol
- BRN
- 4240280
- InChI
- InChI=1/C12H14N2O2.ClH/c1-16-12(15)10(13)6-8-7-14-11-5-3-2-4-9(8)11;/h2-5,7,10,14H,6,13H2,1H3;1H/t10-;/s3
- InChIKey
- XNFNGGQRDXFYMM-MEQOOBBNNA-N
- SMILES
- C12C=CC=CC=1NC=C2C[C@H](N)C(=O)OC.Cl |&1:10,r|
- CAS DataBase Reference
- 7524-52-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P310Immediately call a POISON CENTER or doctor/physician.
P330Rinse mouth.
P361Remove/Take off immediately all contaminated clothing.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 364517
- Product name
- L-Tryptophan methyl ester hydrochloride
- Purity
- 98%
- Packaging
- 5g
- Price
- $46.6
- Updated
- 2025/07/31
- Product number
- PHR2601
- Product name
- <SC>L</SC>-Tryptophan methyl ester hydrochloride
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 100mg
- Price
- $627
- Updated
- 2025/07/31
- Product number
- 364517
- Product name
- L-Tryptophan methyl ester hydrochloride
- Purity
- 98%
- Packaging
- 25g
- Price
- $132
- Updated
- 2025/07/31
- Product number
- T1657
- Product name
- L-Tryptophan Methyl Ester Hydrochloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $33
- Updated
- 2025/07/31
- Product number
- T1657
- Product name
- L-Tryptophan Methyl Ester Hydrochloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $103
- Updated
- 2025/07/31
Methyl L-tryptophanate hydrochloride Chemical Properties,Usage,Production
Chemical Properties
Methyl L-tryptophanate hydrochloride is White to off-white powder
Uses
Methyl L-tryptophanate hydrochloride may be used to prepare the corresponding amino acid amide L-Tryptophanamide Hydrochloride (Cat. #T89550)
Uses
Amino acid derivative that may be used to prepare the corresponding amino acid amide L-Tryptophanamide Hydrochloride (Cat. #T89550).
Uses
L-Tryptophan methyl ester hydrochloride can be used as a reactant to prepare:
- Oxamoyl derivatives of N-(2-aminobenzoyl)-L-tryptophan (dipeptides) by acylation reaction with 3,1-benzoxazinones.
- Tadalafil (Cialis), a type-V phosphodiesterase (PDE5) inhibitor.
- Isoroquefortine C.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
67-56-1
73-22-3
7524-52-9
(2) Preparation of L-tryptophan methyl ester hydrochloride: 60 mL of methanol was added to a 100 mL round-bottomed flask under ice bath conditions. Subsequently, 4 mL of sulfoxide chloride (SOCl2) was slowly added dropwise through a constant-pressure dropping funnel (equipped with a drying tube at the top), and NaOH solution was used to absorb the resulting exhaust gas. After the reaction mixture was reacted under stirring conditions for 1 h, 8 mmol of L-tryptophan (3d) was added and stirring was continued for 30 min at room temperature. After that, the reaction system was warmed up to 66 °C and the reaction was refluxed for 6 hours. The reaction process was monitored by thin-layer chromatography (TLC) using 2% ninhydrin ethanol solution as a color developer until the raw material spot disappeared. Upon completion of the reaction, the solvent was removed by evaporation to give L-tryptophan methyl ester hydrochloride in 100% yield.
References
[1] Tetrahedron, 2001, vol. 57, # 51, p. 10181 - 10189
[2] Patent: US2014/206741, 2014, A1. Location in patent: Paragraph 0111
[3] European Journal of Medicinal Chemistry, 2016, vol. 114, p. 318 - 327
[4] New Journal of Chemistry, 2018, vol. 42, # 16, p. 13549 - 13557
[5] Organic and Biomolecular Chemistry, 2014, vol. 12, # 41, p. 8280 - 8287
Methyl L-tryptophanate hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl L-tryptophanate hydrochloride manufacturers
- Product
- H-L-Trp-OMe.HCl 7524-52-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-04-03
- Product
- L-TRYPTOPHAN METHYL ESTER HCL 7524-52-9
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2024-08-15
- Product
- Methyl L-tryptophanate hydrochloride 7524-52-9
- Price
- US $9.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000tons
- Release date
- 2023-05-29