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BENZO[B]THIOPHENE-3-CARBONITRILE

Product Name
BENZO[B]THIOPHENE-3-CARBONITRILE
CAS No.
24434-84-2
Chemical Name
BENZO[B]THIOPHENE-3-CARBONITRILE
Synonyms
BUTTPARK 147\16-61;Benzothiophene-3-nitrile;3-Cyano-1-benzothiophene;3-CYANOBENZO[B]THIOPHENE;Benzothiophene-3-carbonitrile;1-BENZOTHIOPHENE-3-CARBONITRILE;BENZO[B]THIOPHENE-3-CARBONITRILE;Benzo[b]thiophene-3-carbonitrile 97%;Benzo(b)thiophene-3-carbonitrile ,97%;Benzo[b]thiophene-3-carbonitrile
CBNumber
CB4294571
Molecular Formula
C9H5NS
Formula Weight
159.21
MOL File
24434-84-2.mol
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BENZO[B]THIOPHENE-3-CARBONITRILE Property

Melting point:
71-75 °C
Boiling point:
312.7±15.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
Appearance
White to light yellow Solid
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26
WGK Germany 
3
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
665975
Product name
Benzo[b]thiophene-3-carbonitrile
Purity
97%
Packaging
1g
Price
$73
Updated
2023/06/20
TRC
Product number
B276755
Product name
Benzo[b]thiophene-3-carbonitrile
Packaging
500mg
Price
$130
Updated
2021/12/16
Apolloscientific
Product number
OR913339
Product name
Benzo[b]thiophene-3-carbonitrile
Purity
95%
Packaging
1g
Price
$153
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK788919
Product name
Benzothiophene-3-carbonitrile
Purity
97%
Packaging
1g
Price
$91
Updated
2021/12/16
SynQuest Laboratories
Product number
7H37-1-0F
Product name
Benzo[b]thiophene-3-carbonitrile
Purity
95%
Packaging
1g
Price
$168
Updated
2021/12/16
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BENZO[B]THIOPHENE-3-CARBONITRILE Chemical Properties,Usage,Production

Chemical Properties

White to light brown solid

Synthesis

5381-20-4

24434-84-2

General procedure for the synthesis of benzo[b]thiophene-3-carbonitrile from 3-formylbenzothiophene: To a premixed mixed solution of hexafluoroisopropanol (HFIP) and acetonitrile (ACN) (2.0 mL, 1:1) under nitrogen protection was added aromatic aldehyde 1 (0.500 mmol, 1.0 equiv.) and trimethylsilyl azide (TMSN3; 115 mg, 1.00 mmol, 2.0 equiv). Subsequently, trifluoromethanesulfonic acid (TfOH; 17.7 μL, 0.200 mmol, 0.40 eq.) was added to two dry vials, and exothermic and rapid foaming phenomena due to gas production were immediately observed. The vial was quickly capped and the reaction mixture was stirred at room temperature for 20 to 75 min. Upon completion of the reaction, the reaction mixture was concentrated under nitrogen atmosphere. The obtained residue was suspended in a solvent mixture of dichloromethane (CH2Cl2) and hexane and loaded through a sample cassette containing 5 g silica gel. Purification was carried out by normal-phase silica gel fast column chromatography using a CombiFlash purification system, and suitable elution fractions were collected and concentrated to give the target product benzo[b]thiophene-3-carbonitrile (2).

References

[1] Molecules, 2016, vol. 21, # 1,
[2] Organic and Biomolecular Chemistry, 2016, vol. 14, # 5, p. 1840 - 1840
[3] Tetrahedron Letters, 2013, vol. 54, # 17, p. 2177 - 2179
[4] Organic and Biomolecular Chemistry, 2015, vol. 13, # 30, p. 8322 - 8329

BENZO[B]THIOPHENE-3-CARBONITRILE Preparation Products And Raw materials

Raw materials

Copper(I) Cyanide Thianaphthene Sodium acetate Chloroform Bromine Pyridine

Preparation Products

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24434-84-2, BENZO[B]THIOPHENE-3-CARBONITRILERelated Search:

5-Benzoxazolecarboxaldehyde (9CI) BENZO[E]THIENO[2,3-B]THIEPIN-4(9H)-ONE Benzo[b]thiophene-4-carbonitrile 2-AMINO-6-METHYL-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBONITRILE BENZO(B)THIOPHENE-5-CARBONITRILE BENZO[B]THIOPHENE-3-CARBONITRILE Benzo[b]thiophene-2-carbonitrile 2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZO[B]THIOPHENE-3-CARBONITRILE,2-AMINO-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBONITRILE Benzo[b]thiophene-3-carbonitrile, 2-nitro- (9CI) Benzo[b]thiophene-7-carbonitrile,Benzo[b]thiophene-7-carbonitrile 97% 5-CHLORO-1-BENZOTHIOPHENE-3-CARBONITRILE 2-(2-FORMYL-1H-PYRROL-1-YL)-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBONITRILE 2-AMINO-5-[2-(4-ETHOXY-PHENYL)-VINYL]-7,7-DIMETHYL-6,7-DIHYDRO-BENZO[B]THIOPHENE-3-CARBONITRILE 2-Amino-7,7-dimethyl-5-[2-(3-methyl-thiophen-2-yl)-vinyl]-6,7-dihydro-benzo[b]thiophene-3-carbonitrile 2-(3-FORMYL-2,5-DIMETHYLPYRROL-1-YL)-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBONITRILE 3-AMINO-4-METHYL-6-TRIFLUOROMETHYL-BENZO[B]THIOPHENE-2-CARBONITRILE 4,5,6,7-Tetrahydro-2-(2-amino-5-methoxyphenylazo)benzo[b]thiophene-3-carbonitrile 4,5,6,7-Tetrahydro-2-(2-amino-5-methylphenylazo)benzo[b]thiophene-3-carbonitrile

  • BENZO[B]THIOPHENE-3-CARBONITRILE
  • BUTTPARK 147\16-61
  • 3-CYANOBENZO[B]THIOPHENE
  • Benzothiophene-3-carbonitrile
  • 1-BENZOTHIOPHENE-3-CARBONITRILE
  • 3-Cyano-1-benzothiophene
  • Benzo(b)thiophene-3-carbonitrile ,97%
  • Benzothiophene-3-nitrile
  • Benzo[b]thiophene-3-carbonitrile 97%
  • BENZO[B]THIOPHENE-3-CARBONITRILE ISO 9001：2015 REACH
  • Benzo[<i>b</i>]thiophene-3-carbonitrile
  • 24434-84-2
  • Benzothiophenes
  • Building Blocks
  • Chemical Synthesis
  • Heterocyclic Building Blocks