ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID

ChemicalBook > CAS DataBase List > ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID

ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID

Product Name: ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID
CAS No.: 31842-01-0
Chemical Name: ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID
Synonyms: k4277;flosin;Praxis;flosint;Bor-ind;Reumofe;isindone;Reumofene;INDOPROFEN;Aids025462
CBNumber: CB4297426
Molecular Formula: C17H15NO3
Formula Weight: 281.31
MOL File: 31842-01-0.mol

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ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID Property

Melting point:: 213-214°
Boiling point:: 423.97°C (rough estimate)
Density: 1.1302 (rough estimate)
refractive index: 1.4500 (estimate)
storage temp.: 2-8°C
solubility: Methanol (Slightly, Sonicated)
form: Solid
pka: pKa 5.8 (Uncertain)
color: White to off-white

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Safety

Hazard Codes: T
Risk Statements: 25-40
Safety Statements: 22-36/37/39-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
RTECS: MU6645000
Toxicity: LD50 in rats (mg/kg): 58.66 i.v.; 60.83 orally (Buttinoni)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I3132
Product name: Indoprofen
Purity: analytical standard
Packaging: 1g
Price: $40.5
Updated: 2022/05/15

TRC

Product number: I645000
Product name: Indoprofen
Packaging: 10mg
Price: $110
Updated: 2021/12/16

TRC

Product number: I645000
Product name: Indoprofen
Packaging: 250mg
Price: $715
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008560
Product name: INDOPROFEN
Purity: 95.00%
Packaging: 1G
Price: $525
Updated: 2021/12/16

AK Scientific

Product number: X6838
Product name: Indoprofen
Packaging: 100mg
Price: $495
Updated: 2021/12/16

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ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID Chemical Properties,Usage,Production

Chemical Properties

ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID is Off-White Solid

Originator

Flosint,Carlo Erba,Italy,1976

Uses

ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID is a non-steroidal anti-inflammatory agent used for treatment of pain and inflammation

Uses

analgesic, antiinflammatory

Definition

ChEBI: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(1-oxo-1,3-dihydroisoindol-2-yl)phenyl group. Initially used as an anti-inflammatory and analgesic, it was withdrawn from the market due to causi g severe gastrointestinal bleeding. It has been subsequently found to increase production of the survival motor neuron protein.

Manufacturing Process

The mixture of 7.9 g of ethyl α-(4-aminophenyl)propionate and 8.3 g of ethyl 2-chloromethylbenzoate is refluxed under nitrogen for one hour. The residue is recrystallized from hexane, to yield the ethyl α-[4-(1-oxo-isoindolino)-phenyl]- propionate of the formulamelting at 104° to 106°C. The mixture of 4.5 g thereof, 1.6 g of potassiumhydroxide, 2 ml of water and 250 ml of ethanol is refluxed under nitrogen for 2 hours and evaporated under reduced pressure. The residue is taken up in water, the solution washed with chloroform, acidified with hydrochloric acid and extracted with ethyl acetate. The extract is dried, evaporated and the residue recrystallized from ethyl acetate, to yield the corresponding free acid melting at 208° to 210°C. (Procedure reported in US Patent 3,767,805.)

brand name

Endyne;Fenint;Flogosan;Flosine;Flosyn;K 4277;Miantor.

Therapeutic Function

Antiinflammatory

World Health Organization (WHO)

Indoprofen, a nonsteroidal anti-inflammatory agent, was introduced in 1976 for the treatment of rheumatic disorders. By 1983 its use had been associated with serious adverse effects, some of which were fatal. This led to its withdrawal in the United Kingdom and Cyprus. In 1984 reports of intestinal tumours in rats led to the drug's temporary withdrawal in Germany and Italy. This was followed immediately by the suspension of marketing worldwide by the major manufacturer.

ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID manufacturers

Career Henan Chemical Co

Product: ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID 31842-01-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-03-05

31842-01-0, ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACIDRelated Search:

Indoramin D5 Indacaterol Maleate Veratraldehyde Benyl propionic methyl ester Indole-3-carboxaldehyde DL-INDOLE-3-LACTIC ACID INDOMETHACIN ACYL-B-D-GLUCURONIDE 3-INDOXYL SULFATE POTASSIUM SALT Indole Ibuprofen 4-(DIMETHYLAMINO)PHENYLACETIC ACID 4-(DIMETHYLAMINO)PHENETHYL ALCOHOL ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID dexindoprofen Actarit Indobufen 4-ISOPROPYLACETANILIDE 4-Aminophenylacetic acid

ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID

1-oxo-2-(p-((alpha-methyl)carboxymethyl)phenyl)isoindoline

2-(4-(1-carboxyethyl)phenyl)-1-isoindolinone

2-(p-(1-oxo-2-isoindolinyl)phenyl)-propionicaci

4-(1,3-dihydro-1-oxo-2h-isoindol-2-yl)-alpha-methyl-benzeneaceticaci

4-(1,3-dihydro-1-oxo-2h-isoindol-2-yl)-alpha-methylbenzeneaceticacid

alpha-(4-(1-oxo-2-isoindolinyl)phenyl)-propionicaci

alpha-(4-(1-oxo-2-iso-indolinyl)-phenyl)-propionicacid

flosin

INDOPROFEN

flosint

isindone

k4277

p-(1-oxo-2-isoindolinyl)-hydratropicaci

p-(1-oxo-2-isoindolinyl)-hydratropicacid

α-methyl-p-(1-oxo-2-isoindolinyl)benzeneacetic acid

1-Oxo-2-[p-[(a-methyl)carboxymethyl]phenyl]isoindoline

2-[4-(1-Oxo-2-isoindolinyl)phenyl]propanoic Acid

4-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-a-methylbenzeneacetic Acid

Bor-ind

Praxis

Reumofe

(±)-Indoprofe

Indoprofen Solution, 100ppm

2-[p-(1-Oxo-2-isoindolinyl)phenyl]propionic acid

4-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-α-methylbenzeneacetic acid

Aids025462

Aids-025462

Reumofene

Indoprofen,α-Methyl-p-(1-oxo-2-isoindolinyl)benzeneacetic acid

2-(4-(1-oxoisoindolin-2-yl)phenyl)propanoic acid

(+/-) Indoprof

1-Oxo-2-[p-[(α-Methyl)carboxyMethyl]phenyl]isoindoline

Benzeneacetic acid, 4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-α-methyl-

inhibit,Indoprofen,Inhibitor

Indoprofen Indoprofen

Indoprofen, 10 mM in DMSO

31842-01-0

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