CARM1-IN-1
- Product Name
- CARM1-IN-1
- CAS No.
- 1020399-49-8
- Chemical Name
- CARM1-IN-1
- Synonyms
- CARM1-IN-1;CARM1-IN-7g;CARM1 inhibitor 1;PRMT4/CARM1 Inhibitor;CARM1-IN-1, 10 mM in DMSO;4-Piperidinone, 3,5-bis[(3-bromo-4-hydroxyphenyl)methylene]-1-(phenylmethyl)-
- CBNumber
- CB43034459
- Molecular Formula
- C26H21Br2NO3
- Formula Weight
- 555.26
- MOL File
- 1020399-49-8.mol
CARM1-IN-1 Property
- Boiling point:
- 659.8±55.0 °C(Predicted)
- Density
- 1.647±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL; Ethanol: 0.25 mg/mL
- form
- A crystalline solid
- pka
- 7.77±0.35(Predicted)
- color
- Yellow to orange
N-Bromosuccinimide Price
- Product number
- 11033
- Product name
- PRMT4/CARM1 Inhibitor
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 11033
- Product name
- PRMT4/CARM1 Inhibitor
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $129
- Updated
- 2024/03/01
- Product number
- 11033
- Product name
- PRMT4/CARM1 Inhibitor
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $553
- Updated
- 2024/03/01
- Product number
- CS-3970
- Product name
- CARM1-IN-1
- Packaging
- 5mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- CS-3970
- Product name
- CARM1-IN-1
- Packaging
- 10mg
- Price
- $180
- Updated
- 2021/12/16
CARM1-IN-1 Chemical Properties,Usage,Production
Uses
CARM1-IN-1 (compound 7g) is a highly potent and selective inhibitor of CARM1 (IC50=8.6 μM, CARM1/PABP1), with low inhibitory activity against PRMT1 and SET7 (IC50 >667 μM). CARM1-IN-1 inhibits the methylation activity of CARM1 and the methylation levels of different substrates, such as PABP1, CA150, SmB, and H3. CARM1-IN-1 also inhibits the promoter activity of prostate-specific antigen (PSA) without significant cytotoxicity[1].
Biological Activity
Cell permeable: yes', 'Primary Target
PRMT4', 'Reversible: yes', 'Secondary Target
SET7', 'Target IC50: CARM1-mediated methylation over PRMT1 and SET7 (IC60 = 7.1, 63 and 943 μM,
IC 50
PRMT4
References
[1] Cheng D, et al. Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity. J Med Chem. 2011 Jul 14;54(13):4928-32. DOI:10.1021/jm200453n
CARM1-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
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