ChemicalBook > CAS DataBase List > TC-G 24

TC-G 24

Product Name
TC-G 24
CAS No.
1257256-44-2
Chemical Name
TC-G 24
Synonyms
TC-G 24;TCG 24,TC G 24;GSK-3β Inhibitor XXV;N-(3-Chloro-4-methylphenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol-2-amine;1,3,4-Oxadiazol-2-amine, N-(3-chloro-4-methylphenyl)-5-(4-nitrophenyl)-;(3-Chloro-4-methyl-phenyl)-[5-(4-nitro-phenyl)-[1,3,4]oxadiazol-2-yl]-amine
CBNumber
CB43037551
Molecular Formula
C15H11ClN4O3
Formula Weight
330.73
MOL File
1257256-44-2.mol
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TC-G 24 Property

Boiling point:
502.9±60.0 °C(Predicted)
Density 
1.437±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble to 10 mM in DMSO with gentle warming
form 
Powder
pka
-1.70±0.50(Predicted)
color 
yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
4353
Product name
TC-G24
Purity
≥98%(HPLC)
Packaging
10
Price
$217
Updated
2021/12/16
Tocris
Product number
4353
Product name
TC-G24
Purity
≥98%(HPLC)
Packaging
50
Price
$851
Updated
2021/12/16
TRC
Product number
T125285
Product name
TC-G24
Packaging
50mg
Price
$810
Updated
2021/12/16
Usbiological
Product number
256846
Product name
TC-G 24
Packaging
10mg
Price
$466
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0001431
Product name
TCG-24
Purity
98.00%
Packaging
5MG
Price
$500.04
Updated
2021/12/16
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TC-G 24 Chemical Properties,Usage,Production

Uses

TC-G 24 is a novel GSK-3β inhibitor with potent in vitro and in vivo activities and excellent brain permeability.

in vivo

TC-G 24 (Compound 24) (0-15 mg/kg; i.p.; once) significantly raises liver glycogen content in a dose-dependent manner without obvious toxicity and can cross the BBB[1].

Animal Model:Six-week-old male C57BL/6N mice with weights averaging 22 g[1]
Dosage:1, 5, and 15 mg/kg
Administration:Intraperitoneal injection, once
Result:Significantly raised liver glycogen content in a dose-dependent manner without obvious toxicity. Was detected in the brain at concentrations higher than in plasma for all three tested doses (38 ± 6, 113 ± 54 and 286 ± 58 ng/g brain tissue at 1, 5 and 15 mg/kg, respectively).

IC 50

GSK-3β: 17.1 nM (IC50)

storage

Store at +4°C

TC-G 24 Preparation Products And Raw materials

Raw materials

Preparation Products

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TC-G 24 Suppliers

China 21 United Kingdom 1 United States 6 USA 1 Global 29
Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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Career Henan Chemica Co
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+86-0371-86658258 +8613203830695
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0371-86658258
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laboratory@coreychem.com
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MedBioPharmaceutical Technology Inc
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021-69568360 18916172912
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order@med-bio.cn
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China
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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Shanghai Aladdin Biochemical Technology Co.,Ltd.
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400-6206333 13167063860
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R&D Systems, Inc
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18003437475
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Shanghai Ken chemical Technology Co.,ltd
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Merck KGaA
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Biosynth Biological Technology (Suzhou) Co Ltd
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Hangzhou MolCore BioPharmatech Co.,Ltd.
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+86-057181025280; +8617767106207
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sales@molcore.com
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Guangzhou Squirrel Biotechnology Co., Ltd.
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Guangzhou Tuoshan Biotechnology Co., Ltd.
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Guangzhou Junuo Biotechnology Co., Ltd.
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Beijing Bolide Biotechnology Co., Ltd.
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Shanghai Hao Biological Technology Co., Ltd.
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Shanghai Yihui Biotechnology Co., Ltd.
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Shanghai Weiwei Biological Technology Co., Ltd.
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Qingdao Jieshikang Biotechnology Co., Ltd.
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1257256-44-2, TC-G 24Related Search:


  • N-(3-Chloro-4-methylphenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol-2-amine
  • TC-G 24
  • (3-Chloro-4-methyl-phenyl)-[5-(4-nitro-phenyl)-[1,3,4]oxadiazol-2-yl]-amine
  • 1,3,4-Oxadiazol-2-amine, N-(3-chloro-4-methylphenyl)-5-(4-nitrophenyl)-
  • TCG 24,TC G 24
  • GSK-3β Inhibitor XXV
  • 1257256-44-2