5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine

Product Name: 5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine
CAS No.: 1527503-11-2
Chemical Name: 5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine
Synonyms: A-336;A-366;CS-2077;A-366,MV4;A-366 (A366);A-366; A366;A 366;A-366, 10 mM in DMSO;5'-methoxy-6'-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3'-indol]-2'-amine;5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine;Spiro[cyclobutane-1,3'-[3H]indol]-2'-amine, 5'-methoxy-6'-[3-(1-pyrrolidinyl)propoxy]-
CBNumber: CB43038523
Molecular Formula: C19H27N3O2
Formula Weight: 329.44
MOL File: 1527503-11-2.mol

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5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine Property

Boiling point:: 533.6±60.0 °C(Predicted)
Density: 1.29±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO : 50 mg/mL (151.77 mM; Need ultrasonic)
form: powder
pka: 10.18±0.20(Predicted)
color: white to beige
InChI: InChI=1S/C19H27N3O2/c1-23-16-12-14-15(21-18(20)19(14)6-4-7-19)13-17(16)24-11-5-10-22-8-2-3-9-22/h12-13H,2-11H2,1H3,(H2,20,21)
InChIKey: BKCDJTRMYWSXMC-UHFFFAOYSA-N
SMILES: C12(C3=C(N=C1N)C=C(OCCCN1CCCC1)C(OC)=C3)CCC2

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Safety

RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
Storage Class: 11 - Combustible Solids
Hazard Classifications: Aquatic Acute 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1410
Product name: A-366
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $126
Updated: 2026/03/19

Sigma-Aldrich

Product number: SML1410
Product name: A-366
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $495
Updated: 2026/03/19

Cayman Chemical

Product number: 16081
Product name: A-366
Purity: ≥98%
Packaging: 5mg
Price: $85
Updated: 2024/03/01

Cayman Chemical

Product number: 16081
Product name: A-366
Purity: ≥98%
Packaging: 10mg
Price: $158
Updated: 2024/03/01

Cayman Chemical

Product number: 16081
Product name: A-366
Purity: ≥98%
Packaging: 50mg
Price: $661
Updated: 2024/03/01

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5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine Chemical Properties,Usage,Production

Uses

A-366 acts as a potent peptide-competitive inhibitor of the lysine methyltransferase G9a. 1000 fold selectivity over other methyl transferases.

Biochem/physiol Actions

A-366 is an SGC chemical probe for G9a/GLP, developed in collaboration with Abbvie. A-366 is a potent, selective inhibitor of the histone methyltransferase G9a. The IC50 values for G9a inhbition in enzymatic and cell based assays are 3.3 and approximately 3 μM, respectively. A-366 has little or no detectable activity against a panel of 21 other methyltransferases. For full characterization details, please visit the A-366 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

in vivo

A-366 (30 mg/kg; osmotic mini-pump; daily for 14 days) treatment of MV4;11 xenografts elicits growth inhibition^[4].

Animal Model:	6-8 week old SCID-beige female mice (MV4;11 xenografts)^[4]
Dosage:	30 mg/kg
Administration:	By osmotic mini-pump; daily for 14 days
Result:	A modest 45% tumor growth inhibition resulting from A-366 treatment in this model.

IC 50

EHMT2/G9a/KMT1C; EHMT1/GLP/KMT1D

storage

Store at -20°C

5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine Suppliers

China 71 India 1 United Kingdom 1 United States 13 Global 86

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1527503-11-2, 5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amineRelated Search:

CS-2077

A-366; A366;A 366

5'-methoxy-6'-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3'-indol]-2'-amine

5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine

A-366

A-336

Spiro[cyclobutane-1,3'-[3H]indol]-2'-amine, 5'-methoxy-6'-[3-(1-pyrrolidinyl)propoxy]-

11,selective,cells,peptide-competitive,epigenetics,Inhibitor,interaction,inhibit,H3K4me3,Epigenetic Reader Domain,leukemia,Histone Methyltransferase,methyltransferase

A-366,MV4

A-366, 10 mM in DMSO

A-366 (A366)

1527503-11-2