4-Chloro-5,6-dimethoxypyrimidine
- Product Name
- 4-Chloro-5,6-dimethoxypyrimidine
- CAS No.
- 5193-88-4
- Chemical Name
- 4-Chloro-5,6-dimethoxypyrimidine
- Synonyms
- Pyrimidine, 4-chloro-5,6-dimethoxy-
- CBNumber
- CB43039595
- Molecular Formula
- C6H7ClN2O2
- Formula Weight
- 174.59
- MOL File
- 5193-88-4.mol
4-Chloro-5,6-dimethoxypyrimidine Property
- Melting point:
- 53-55 °C
- Boiling point:
- 250.8±35.0 °C(Predicted)
- Density
- 1.285±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.53±0.26(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H320Causes eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 2692DA
- Product name
- 4-Chloro-5,6-dimethoxypyrimidine
- Packaging
- 5g
- Price
- $802
- Updated
- 2021/12/16
- Product number
- A136138
- Product name
- 4-Chloro-5,6-dimethoxypyrimidine
- Purity
- 97%
- Packaging
- 100mg
- Price
- $29
- Updated
- 2021/12/16
- Product number
- A136138
- Product name
- 4-Chloro-5,6-dimethoxypyrimidine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $43
- Updated
- 2021/12/16
- Product number
- A136138
- Product name
- 4-Chloro-5,6-dimethoxypyrimidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $108
- Updated
- 2021/12/16
- Product number
- CM253367
- Product name
- 4-Chloro-5,6-dimethoxypyrimidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $153
- Updated
- 2021/12/16
4-Chloro-5,6-dimethoxypyrimidine Chemical Properties,Usage,Production
Synthesis
124-41-4
5018-38-2
5193-88-4
Preparation of compound 4-chloro-5,6-dimethoxypyrimidine: 4,6-dichloro-5-methoxypyrimidine (300 mg, 1.68 mmol) was dissolved in methanol (10 mL), followed by cooling of the reaction mixture to 0 °C. Under stirring, sodium methanolate (99 mg, 1.85 mmol) was slowly added, and after addition, the reaction mixture was allowed to gradually warm up to room temperature. The reaction mixture was stirred continuously for 19 hours at room temperature. After completion of the reaction, methanol was removed by distillation under reduced pressure. The resulting residue was diluted with ethyl acetate and washed sequentially with saturated aqueous sodium bicarbonate solution, aqueous ammonium chloride solution and brine. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with 0 to 10% ethyl acetate/hexane as eluent to give 4-chloro-5,6-dimethoxypyrimidine as a white solid (168 mg, 57% yield). Physical Properties: Melting point 53-55°C. NMR data: 1H NMR (400 MHz, CDCl3) δ 8.27 (s, 1H), 4.03 (s, 3H), 3.88 (s, 3H); 13C NMR (100 MHz, CDCl3) δ 163.6, 151.6, 151.3, 138.2, 60.7, 54.8.
References
[1] Patent: WO2014/43252, 2014, A2. Location in patent: Page/Page column 62
4-Chloro-5,6-dimethoxypyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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