ChemicalBook > CAS DataBase List > Palvanil
Palvanil
- Product Name
- Palvanil
- CAS No.
- 69693-13-6
- Chemical Name
- Palvanil
- Synonyms
- Palvanil;Palvanil, 10 mM in DMSO;N-(4-Hydroxy-3-methoxybenzyl)palmitamide;N-[(4-hydroxy-3-methoxyphenyl)methyl]hexadecanamide;Hexadecanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-;anti-inflammation,inhibit,HEK-293,Inhibitor,anti-nociceptive,Palvanil
- CBNumber
- CB43040227
- Molecular Formula
- C24H41NO3
- Formula Weight
- 391.59
- MOL File
- 69693-13-6.mol
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Palvanil Property
- Melting point:
- 83-85 °C
- Boiling point:
- 565.4±40.0 °C(Predicted)
- Density
- 0.983±0.06 g/cm3(Predicted)
- pka
- 9.76±0.20(Predicted)
- InChI
- InChI=1S/C24H41NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-24(27)25-20-21-17-18-22(26)23(19-21)28-2/h17-19,26H,3-16,20H2,1-2H3,(H,25,27)
- InChIKey
- SGEUEXJZQFSBNX-UHFFFAOYSA-N
- SMILES
- C(NCC1=CC=C(O)C(OC)=C1)(=O)CCCCCCCCCCCCCCC
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Palvanil Chemical Properties,Usage,Production
Uses
Palvanil is a Capsaicin.html" class="link-product" target="_blank">Capsaicin (HY-10448) analogue, shows strong desensitizing capability against the TRPV1 receptor. Palvanil shows anti-nociceptive and anti-inflammation effects[1][2].
in vivo
Palvanil (subcutaneous injection; 1 or 10 mg/kg; once) treatment shows hypothermic effect[2].
Palvanil (intraperitoneal injection; 100 μL (15 nM) per mouse; once) treatment reduces Capsaicin-induced bronchoconstriction[2].
Palvanil (intravenous injection; 0.5, 0.75, and 1 mg/kg; once) treatment shows antinociceptive effects on Formalin-induced nocifensive behavior[2].
Palvanil (intravenous injection; 0.5, 0.75, and 1 mg/kg; once) treatment inhibits Carrageenan-induced inflammation[2].
Palvanil (intravenous injection; 0.5 and 1 mg/kg; once daily; 7 days) reduces mechanical allodynia and thermal hyperalgesia in spared nerve injury (SNI) mice[2].
| Animal Model: | Male CD-1 mice[2] |
| Dosage: | 1 or 10 mg/kg |
| Administration: | Subcutaneous injection; 1 or 10 mg/kg; once |
| Result: | Led to a slight and short lasting hypothermic effect, produced late hyperthermia. |
| Animal Model: | Female BALB/C mice[2] |
| Dosage: | 100 μL (15 nM) per mouse |
| Administration: | Intraperitoneal injection; 100 μL (15 nM) per mouse; once |
| Result: | Induced a significantly lower bronchoconstriction (from 0.47 to 0.605 cm H2O/L/s). |
| Animal Model: | Male CD-1 mice received formalin[2] |
| Dosage: | 0.5, 0.75, and 1 mg/kg |
| Administration: | Intravenous injection; 0.5, 0.75, and 1 mg/kg; once |
| Result: | Reduced the second phase of Formalin-induced nociceptive behaviour in a dose-dependent manner. |
| Animal Model: | Male C57BL/6J mice with acute inflammation induced by Carrageenan[2] |
| Dosage: | 2.5 mg/kg |
| Administration: | Intravenous injection; 2.5 mg/kg; once |
| Result: | Reduced the volume of the oedema in the ipsilateral hind paw (64%). |
| Animal Model: | Male CD-1 mice[2] |
| Dosage: | 0.5 and 1 mg/kg |
| Administration: | Intravenous injection; 0.5 and 1 mg/kg; once daily; 7 days |
| Result: | Reduced mechanical allodynia and thermal hyperalgesia at 3 and 7 days after nerve injury in a dose-dependent manner. |
References
[1] Luciano De Petrocellis, et al. N-palmitoyl-vanillamide (palvanil) is a non-pungent analogue of capsaicin with stronger desensitizing capability against the TRPV1 receptor and anti-hyperalgesic activity. Pharmacol Res. 2011 Apr;63(4):294-9. DOI:10.1016/j.phrs.2010.12.019
[2] Livio Luongo, et al. Palvanil, a non-pungent capsaicin analogue, inhibits inflammatory and neuropathic pain with little effects on bronchopulmonary function and body temperature. Pharmacol Res. 2012 Sep;66(3):243-50. DOI:10.1016/j.phrs.2012.05.005
Palvanil Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Palvanil manufacturers
Career Henan Chemical Co
- Product
- N-[(4-hydroxy-3-methoxyphenyl)methyl]hexadecanamide 69693-13-6
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- as request
- Release date
- 2018-12-25
GIHI CHEMICALS CO.,LIMITED
- Product
- Palvanil 69693-13-6
- Price
- US $0.00-10.00/kg
- Min. Order
- 1Kgs/plastic barrel
- Purity
- 99%
- Supply Ability
- 500kgs
- Release date
- 2019-01-31