Exendin-4 (Acetate)

Product Name: Exendin-4 (Acetate)
CAS No.: 914454-01-6
Chemical Name: Exendin-4 (Acetate)
Synonyms: Exendin-4 (Acetate);Exendin-4 (48-86) amide (acetate);Exenatide acetate (Exendin-4 acetate);Exendin-4 Acetate,Exenatide acetate, >98%;Exenatide,Exendin 4 acetate,Glucagon Receptor,Exendin-4,inhibit,Exendin4 acetate,Exendin 4,Exendin4,GCGR,Inhibitor
CBNumber: CB43048652
Molecular Formula: C186H285N50O62RS
Formula Weight: 4245.62
MOL File: 914454-01-6.mol

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Exendin-4 (Acetate) Property

storage temp.: Store at -20°C
solubility: PBS (pH 7.2): 3 mg/ml
form: A crystalline solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11096
Product name: Exendin-4 (acetate)
Purity: ≥95%
Packaging: 500μg
Price: $101
Updated: 2024/03/01

Cayman Chemical

Product number: 11096
Product name: Exendin-4 (acetate)
Purity: ≥95%
Packaging: 1mg
Price: $162
Updated: 2024/03/01

Cayman Chemical

Product number: 11096
Product name: Exendin-4 (acetate)
Purity: ≥95%
Packaging: 5mg
Price: $379
Updated: 2024/03/01

ChemScene

Product number: CS-5100
Product name: Exendin-4acetate
Purity: 99.44%
Packaging: 5mg
Price: $168
Updated: 2021/12/16

ChemScene

Product number: CS-5100
Product name: Exendin-4acetate
Purity: 99.44%
Packaging: 10mg
Price: $252
Updated: 2021/12/16

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Exendin-4 (Acetate) Chemical Properties,Usage,Production

Description

Exendin-4 (48-86) amide is a 39-amino acid peptide fragment corresponding to residues 48-86 of exendin-4, a peptide produced in the salivary gland of the Gila monster, and an agonist of the glucagon-like peptide 1 receptor (GLP-1R; IC₅₀ = 3.5 nM).^1,2 Radiolabeled exendin-4 (48-86) amide localizes to the pancreas, kidneys, and bladder in a porcine model of diabetes induced by streptozotocin .³ Exendin-4 (48-86) amide (10 nmol/kg) improves motor performance in the rotarod test in an mouse model of Parkinson’s disease induced by MPTP.⁴ It reduces MPTP-induced loss of dopaminergic neurons in the substantia nigra in the same model. Formulations containing exendin-4 (48-86) amide have been used in the treatment of type 2 diabetes mellitus.

References

1. Clardy, S.M., Mohan, J.F., Vinegoni, C., et al. Rapid, high efficiency isolation of pancreatic β-cells Sci. Rep. 5,13681(2015).
2. Doyle, M.E., Theodorakis, M.J., Holloway, H.W., et al. The importance of the nine-amino acid C-terminal sequence of exendin-4 for binding to the GLP-1 receptor and for biological activity Regul. Pept. 114(2-3),153-158(2003).
3. Nalin, L., Selvaraju, R.K., Velikyan, I., et al. Positron emission tomography imaging of the glucagon-like peptide-1 receptor in healthy and streptozotocin-induced diabetic pigs Eur. J. Nucl. Med. Mol. Imaging 41(9),1800-1810(2014).
4. Zhang, L., Zhang, L., Li, Y., et al. The novel dual GLP-1/GIP receptor agonist DA-CH5 is superior to single GLP-1 receptor agonists in the MPTP model of Parkinson’s disease J. Parkinsons Dis. 10(2),523-542(2020).

Exendin-4 (Acetate) Preparation Products And Raw materials

Raw materials

Preparation Products

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Exendin-4 (Acetate) Suppliers

China 20 Sweden 1 United States 7 Global 28

Haoyuan Chemexpress Co., Ltd.

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914454-01-6, Exendin-4 (Acetate)Related Search:

Exendin-4 (Acetate)

Exendin-4 Acetate,Exenatide acetate, >98%

Exenatide acetate (Exendin-4 acetate)

Exenatide,Exendin 4 acetate,Glucagon Receptor,Exendin-4,inhibit,Exendin4 acetate,Exendin 4,Exendin4,GCGR,Inhibitor

Exendin-4 (48-86) amide (acetate)

914454-01-6