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Exendin-4 (Acetate)

Product Name
Exendin-4 (Acetate)
CAS No.
914454-01-6
Chemical Name
Exendin-4 (Acetate)
Synonyms
Exendin-4 (Acetate);Exendin-4 (48-86) amide (acetate);Exenatide acetate (Exendin-4 acetate);Exendin-4 Acetate,Exenatide acetate, >98%;Exenatide,Exendin 4 acetate,Glucagon Receptor,Exendin-4,inhibit,Exendin4 acetate,Exendin 4,Exendin4,GCGR,Inhibitor
CBNumber
CB43048652
Molecular Formula
C186H285N50O62RS
Formula Weight
4245.62
MOL File
914454-01-6.mol
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Exendin-4 (Acetate) Property

storage temp. 
Store at -20°C
solubility 
PBS (pH 7.2): 3 mg/ml
form 
A crystalline solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
11096
Product name
Exendin-4 (acetate)
Purity
≥95%
Packaging
500μg
Price
$101
Updated
2024/03/01
Cayman Chemical
Product number
11096
Product name
Exendin-4 (acetate)
Purity
≥95%
Packaging
1mg
Price
$162
Updated
2024/03/01
Cayman Chemical
Product number
11096
Product name
Exendin-4 (acetate)
Purity
≥95%
Packaging
5mg
Price
$379
Updated
2024/03/01
ChemScene
Product number
CS-5100
Product name
Exendin-4acetate
Purity
99.44%
Packaging
5mg
Price
$168
Updated
2021/12/16
ChemScene
Product number
CS-5100
Product name
Exendin-4acetate
Purity
99.44%
Packaging
10mg
Price
$252
Updated
2021/12/16
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Exendin-4 (Acetate) Chemical Properties,Usage,Production

Description

Exendin-4 (48-86) amide is a 39-amino acid peptide fragment corresponding to residues 48-86 of exendin-4, a peptide produced in the salivary gland of the Gila monster, and an agonist of the glucagon-like peptide 1 receptor (GLP-1R; IC50 = 3.5 nM).1,2 Radiolabeled exendin-4 (48-86) amide localizes to the pancreas, kidneys, and bladder in a porcine model of diabetes induced by streptozotocin .3 Exendin-4 (48-86) amide (10 nmol/kg) improves motor performance in the rotarod test in an mouse model of Parkinson’s disease induced by MPTP.4 It reduces MPTP-induced loss of dopaminergic neurons in the substantia nigra in the same model. Formulations containing exendin-4 (48-86) amide have been used in the treatment of type 2 diabetes mellitus.

References

1. Clardy, S.M., Mohan, J.F., Vinegoni, C., et al. Rapid, high efficiency isolation of pancreatic β-cells Sci. Rep. 5,13681(2015).
2. Doyle, M.E., Theodorakis, M.J., Holloway, H.W., et al. The importance of the nine-amino acid C-terminal sequence of exendin-4 for binding to the GLP-1 receptor and for biological activity Regul. Pept. 114(2-3),153-158(2003).
3. Nalin, L., Selvaraju, R.K., Velikyan, I., et al. Positron emission tomography imaging of the glucagon-like peptide-1 receptor in healthy and streptozotocin-induced diabetic pigs Eur. J. Nucl. Med. Mol. Imaging 41(9),1800-1810(2014).
4. Zhang, L., Zhang, L., Li, Y., et al. The novel dual GLP-1/GIP receptor agonist DA-CH5 is superior to single GLP-1 receptor agonists in the MPTP model of Parkinson’s disease J. Parkinsons Dis. 10(2),523-542(2020).

Exendin-4 (Acetate) Preparation Products And Raw materials

Raw materials

Preparation Products

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Exendin-4 (Acetate) Suppliers

China 25 Sweden 1 United States 8 Global 34
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
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58
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
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60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
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58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
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6391
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Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52924
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58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
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65
Cayman Chemical Company
Tel
--
Fax
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
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81

914454-01-6, Exendin-4 (Acetate)Related Search:


  • Exendin-4 (Acetate)
  • Exendin-4 Acetate,Exenatide acetate, >98%
  • Exenatide acetate (Exendin-4 acetate)
  • Exenatide,Exendin 4 acetate,Glucagon Receptor,Exendin-4,inhibit,Exendin4 acetate,Exendin 4,Exendin4,GCGR,Inhibitor
  • Exendin-4 (48-86) amide (acetate)
  • 914454-01-6