THK-523
- Product Name
- THK-523
- CAS No.
- 1573029-17-0
- Chemical Name
- THK-523
- Synonyms
- THK-523;4-(6-(2-fluoroethoxy)quinolin-2-yl)aniline;4-[6-(2-Fluoroethoxy)-2-quinolinyl]benzenamine;Benzenamine, 4-[6-(2-fluoroethoxy)-2-quinolinyl]-
- CBNumber
- CB43049235
- Molecular Formula
- C17H15FN2O
- Formula Weight
- 282.31
- MOL File
- 1573029-17-0.mol
THK-523 Property
- Boiling point:
- 470.3±45.0 °C(Predicted)
- Density
- 1.225±0.06 g/cm3(Predicted)
- pka
- 4.45±0.30(Predicted)
THK-523 Chemical Properties,Usage,Production
Description
THK-523 is a selective Tau ligand, selectively binding to neurofibrillary tangles and neuropils in people with Alzheimer's disease.
Uses
THK-523 has demonstrated its high affinity and selectivity for tau pathology both in vitro and in vivo. 18F-THK523 is a potent tau imaging radiotracer. 18F-THK523 is a potent in vivo tau imaging ligand for Alzheimer's disease[1].
in vivo
THK-523 crosses the blood-brain barrier in mice and the in vivo retention rate in the brain of Tau transgenic mice increased[1].
| Animal Model: | Brain of tau transgenic mice[1] |
| Dosage: | 0.35 μg/kg |
| Administration: | Intravenous injection;25-30 mins |
| Result: | Overexpressed Tau in brain. |
References
[1] Ryuichi Harada, et al. Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology. Eur J Nucl Med Mol Imaging.?2013 Jan;40(1):125-32. DOI:10.1007/s00259-012-2261-2
[2] Michelle T Fodero-Tavoletti,?18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease. Brain.?2011 Apr;134(Pt 4):1089-100. DOI:10.1093/brain/awr038
THK-523 Preparation Products And Raw materials
Raw materials
Preparation Products
THK-523 Suppliers
- Tel
- +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 19961
- Advantage
- 58