JH-II-127

ChemicalBook > CAS DataBase List > JH-II-127

Product Name: JH-II-127
CAS No.: 1700693-08-8
Chemical Name: JH-II-127
Synonyms: JH-II-127;2-anilino-4-methylamino-5-chloropyrrolopyrimidine;2-ANILINO-4-METHYLAMINO-5-CHLOROPYRROLOPYRIMIDINE;JH-II127;JH-II 127;(4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholi;(4-((5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone;[4-[[5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-methanone;[4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone;Methanone, [4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-;HEK293,JHII127,3T3 cells,Inhibitor,LRRK2-G2019S,Ser935,Leucine-rich repeat kinase 2,LRRK2,parkinson’s disease,inhibit,JH II 127,LRRK2-A2016T
CBNumber: CB43049255
Molecular Formula: C19H21ClN6O3
Formula Weight: 416.86
MOL File: 1700693-08-8.mol

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JH-II-127 Property

Melting point:: >166°C (dec.)
Density: 1.458±0.06 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 12.49±0.50(Predicted)
color: White to Pale Beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2569
Product name: JH-II-127
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $123
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2569
Product name: JH-II-127
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $396
Updated: 2024/03/01

Cayman Chemical

Product number: 22905
Product name: JH-II-127
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 22905
Product name: JH-II-127
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 22905
Product name: JH-II-127
Packaging: 10mg
Price: $243
Updated: 2024/03/01

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JH-II-127 Chemical Properties,Usage,Production

Description

JH-II-127 is an orally bioavailable inhibitor of wild-type (WT) and mutant forms of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, as well as LRRK2 containing the G2019S and A2016T substitution mutations (IC₅₀s = 6.6, 2.2, and 47.7 nM, respectively), which are present in certain patients with Parkinson’s disease, but not LRRK2 containing both mutations (IC₅₀ = 3,080 nM). JH-II-127 (0.1-0.3 μM) inhibits phosphorylation of the serines at positions 910 and 935 of WT LRRK2 and LRRK2^G2019S in vitro. It also inhibits Ser935 phosphorylation in vivo in mouse brain, spleen, and kidney when administered at a dose of 30 mg/kg.

Uses

JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor.

storage

Store at -20°C

JH-II-127 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from JH-II-127 manufacturers

Career Henan Chemical Co

Product: JH-II-127 1700693-08-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-26

1700693-08-8, JH-II-127Related Search:

JH-II-127

(4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholi

(4-((5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone

2-anilino-4-methylamino-5-chloropyrrolopyrimidine

2-ANILINO-4-METHYLAMINO-5-CHLOROPYRROLOPYRIMIDINE;JH-II127;JH-II 127

[4-[[5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-methanone

Methanone, [4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-

[4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone

HEK293,JHII127,3T3 cells,Inhibitor,LRRK2-G2019S,Ser935,Leucine-rich repeat kinase 2,LRRK2,parkinson’s disease,inhibit,JH II 127,LRRK2-A2016T

1700693-08-8