4-(4,6-dimorpholino-1,3,5-triazin-2-yl)aniline
- Product Name
- 4-(4,6-dimorpholino-1,3,5-triazin-2-yl)aniline
- CAS No.
- 1197159-91-3
- Chemical Name
- 4-(4,6-dimorpholino-1,3,5-triazin-2-yl)aniline
- Synonyms
- EOS-60915;4-(4,6-dimorpholino-1,3,5-triazin-2-yl)aniline;4-[4,6-Bis(4-morpholinyl)-1,3,5-triazin-2-yl]aniline;4-[4,6-bis(morpholin-4-yl)-1,3,5-triazin-2-yl]aniline;4-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)benzenamine;Benzenamine, 4-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)-
- CBNumber
- CB43050013
- Molecular Formula
- C17H22N6O2
- Formula Weight
- 342.4
- MOL File
- 1197159-91-3.mol
4-(4,6-dimorpholino-1,3,5-triazin-2-yl)aniline Property
- Melting point:
- 266 °C
- Boiling point:
- 616.9±65.0 °C(Predicted)
- Density
- 1.300±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- powder to crystal
- pka
- 6.26±0.10(Predicted)
- color
- White to Light yellow to Light orange
Safety
- HS Code
- 2934.99.4400
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- D5522
- Product name
- 4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)aniline
- Packaging
- 200MG
- Price
- $56
- Updated
- 2026/03/19
- Product number
- D5522
- Product name
- 4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)aniline
- Packaging
- 1G
- Price
- $196
- Updated
- 2026/03/19
- Product number
- 8773DF
- Product name
- 4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)aniline
- Packaging
- 200mg
- Price
- $156
- Updated
- 2021/12/16
- Product number
- A164331
- Product name
- 4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)aniline
- Purity
- 98+%
- Packaging
- 250mg
- Price
- $39
- Updated
- 2021/12/16
- Product number
- A164331
- Product name
- 4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)aniline
- Purity
- 98+%
- Packaging
- 1g
- Price
- $84
- Updated
- 2021/12/16
4-(4,6-dimorpholino-1,3,5-triazin-2-yl)aniline Chemical Properties,Usage,Production
Synthesis
7597-22-0
214360-73-3
1197159-91-3
A mixture of 2-chloro-4,6-dimorpholine-1,3,5-triazine (2.30 g, 0.105 mol) and pinacol ester of 4-aminophenylboronic acid (25.7 g, 0.117 mol) was heated and refluxed for 5 h in the presence of sodium carbonate (23 g, 0.21 mol) and tetrakis(triphenylphosphine)palladium (1 g, 0.5 wt%) in a mixture of water (150 mL) and dimethoxyethane ( DME, 450 mL) in a solvent mixture of water (150 mL) and dimethoxyethane (DME, 450 mL) was heated to reflux for 5 hours. After completion of the reaction, the mixture was cooled to room temperature and filtered through filter paper. The organic layer in the filtrate was separated, washed with brine and concentrated. The concentrated residue was dissolved in dichloromethane, washed again with brine, dried over anhydrous sodium sulfate and concentrated. The resulting solid was ground with ether, filtered and air dried to give the beige solid product 4-(4,6-dimorpholino-1,3,5-triazin-2-yl)aniline (31.5 g, 0.092 mol) in 88% yield. Mass spectrometry analysis showed a molecular ion peak of 343.1 (M + H)+ for the target compound.
References
[1] Patent: WO2010/96619, 2010, A1. Location in patent: Page/Page column 27-28
[2] Patent: US2009/291079, 2009, A1. Location in patent: Page/Page column 37
[3] Journal of Medicinal Chemistry, 2010, vol. 53, # 6, p. 2636 - 2645
[4] Patent: US2017/119778, 2017, A1. Location in patent: Paragraph 0929
[5] Patent: CN108191837, 2018, A. Location in patent: Paragraph 0179; 0180
4-(4,6-dimorpholino-1,3,5-triazin-2-yl)aniline Preparation Products And Raw materials
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