Methyl 4-(trifluoromethyl)-1H-indole-2-carboxylate

Product Name: Methyl 4-(trifluoromethyl)-1H-indole-2-carboxylate
CAS No.: 1098340-27-2
Chemical Name: Methyl 4-(trifluoromethyl)-1H-indole-2-carboxylate
Synonyms: Methyl 4-trifluoromethyl 2-indoleformate;Methyl 4-(trifluoromethyl)-1H-indole-2-carboxylate;4-trifluoromethyl-2-indole-3-carboxylic acid methyl ester;1H-Indole-2-carboxylic acid, 4-(trifluoromethyl)-, methyl ester
CBNumber: CB43052769
Molecular Formula: C11H8F3NO2
Formula Weight: 243.18
MOL File: 1098340-27-2.mol

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Methyl 4-(trifluoromethyl)-1H-indole-2-carboxylate Property

Boiling point:: 334.5±37.0 °C(Predicted)
Density: 1.403±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 13.56±0.30(Predicted)
Appearance: Off-white to light yellow Solid
InChI: InChI=1S/C11H8F3NO2/c1-17-10(16)9-5-6-7(11(12,13)14)3-2-4-8(6)15-9/h2-5,15H,1H3
InChIKey: HEEQKKQXILYZNF-UHFFFAOYSA-N
SMILES: N1C2=C(C(C(F)(F)F)=CC=C2)C=C1C(OC)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: M337828
Product name: Methyl4-(Trifluoromethyl)-1H-indole-2-carboxylate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0035829
Product name: METHYL 4-(TRIFLUOROMETHYL)-1H-INDOLE-2-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $497.72
Updated: 2021/12/16

Ambeed

Product number: A105633
Product name: Methyl4-(trifluoromethyl)-1H-indole-2-carboxylate
Purity: 95%
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Crysdot

Product number: CD11352802
Product name: Methyl4-(trifluoromethyl)-1H-indole-2-carboxylate
Purity: 95+%
Packaging: 1g
Price: $344
Updated: 2021/12/16

Chemenu

Product number: CM256947
Product name: Methyl4-(trifluoromethyl)-1H-indole-2-carboxylate
Purity: 95%
Packaging: 1g
Price: $348
Updated: 2021/12/16

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Methyl 4-(trifluoromethyl)-1H-indole-2-carboxylate Chemical Properties,Usage,Production

Synthesis

1362860-87-4

1098340-27-2

General procedure: methyl 2-azido-3-[2-(trifluoromethyl)phenyl]prop-2-enoate (20.0 mmol) was added to preheated xylene (75 mL) in one go, and the reaction was kept at reflux for 2 hours. After completion of the reaction, the solvent was removed by rotary evaporator and the resulting crude product was purified by silica gel column chromatography with the eluent being a mixed petroleum ether/ethyl acetate solvent. The synthesis of compound 4-(trifluoromethyl)-1H-indole-2-carboxylic acid methyl ester was carried out with reference to the methods reported in literature [9b], [13] and [14].

References

[1] European Journal of Medicinal Chemistry, 2012, vol. 49, p. 379 - 396

Methyl 4-(trifluoromethyl)-1H-indole-2-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 4-(trifluoromethyl)-1H-indole-2-carboxylate Suppliers

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1098340-27-2, Methyl 4-(trifluoromethyl)-1H-indole-2-carboxylateRelated Search:

Methyl 4-(trifluoromethyl)-1H-indole-2-carboxylate

1H-Indole-2-carboxylic acid, 4-(trifluoromethyl)-, methyl ester

4-trifluoromethyl-2-indole-3-carboxylic acid methyl ester

Methyl 4-trifluoromethyl 2-indoleformate

1098340-27-2