Methyl 4-(trifluoromethyl)-1H-indole-2-carboxylate
- Product Name
- Methyl 4-(trifluoromethyl)-1H-indole-2-carboxylate
- CAS No.
- 1098340-27-2
- Chemical Name
- Methyl 4-(trifluoromethyl)-1H-indole-2-carboxylate
- Synonyms
- Methyl 4-trifluoromethyl 2-indoleformate;Methyl 4-(trifluoromethyl)-1H-indole-2-carboxylate;4-trifluoromethyl-2-indole-3-carboxylic acid methyl ester;1H-Indole-2-carboxylic acid, 4-(trifluoromethyl)-, methyl ester
- CBNumber
- CB43052769
- Molecular Formula
- C11H8F3NO2
- Formula Weight
- 243.18
- MOL File
- 1098340-27-2.mol
Methyl 4-(trifluoromethyl)-1H-indole-2-carboxylate Property
- Boiling point:
- 334.5±37.0 °C(Predicted)
- Density
- 1.403±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 13.56±0.30(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C11H8F3NO2/c1-17-10(16)9-5-6-7(11(12,13)14)3-2-4-8(6)15-9/h2-5,15H,1H3
- InChIKey
- HEEQKKQXILYZNF-UHFFFAOYSA-N
- SMILES
- N1C2=C(C(C(F)(F)F)=CC=C2)C=C1C(OC)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- M337828
- Product name
- Methyl4-(Trifluoromethyl)-1H-indole-2-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- HCH0035829
- Product name
- METHYL 4-(TRIFLUOROMETHYL)-1H-INDOLE-2-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.72
- Updated
- 2021/12/16
- Product number
- A105633
- Product name
- Methyl4-(trifluoromethyl)-1H-indole-2-carboxylate
- Purity
- 95%
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CD11352802
- Product name
- Methyl4-(trifluoromethyl)-1H-indole-2-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $344
- Updated
- 2021/12/16
- Product number
- CM256947
- Product name
- Methyl4-(trifluoromethyl)-1H-indole-2-carboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $348
- Updated
- 2021/12/16
Methyl 4-(trifluoromethyl)-1H-indole-2-carboxylate Chemical Properties,Usage,Production
Synthesis
1362860-87-4
1098340-27-2
General procedure: methyl 2-azido-3-[2-(trifluoromethyl)phenyl]prop-2-enoate (20.0 mmol) was added to preheated xylene (75 mL) in one go, and the reaction was kept at reflux for 2 hours. After completion of the reaction, the solvent was removed by rotary evaporator and the resulting crude product was purified by silica gel column chromatography with the eluent being a mixed petroleum ether/ethyl acetate solvent. The synthesis of compound 4-(trifluoromethyl)-1H-indole-2-carboxylic acid methyl ester was carried out with reference to the methods reported in literature [9b], [13] and [14].
References
[1] European Journal of Medicinal Chemistry, 2012, vol. 49, p. 379 - 396
Methyl 4-(trifluoromethyl)-1H-indole-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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