Tenalisib

Product Name: Tenalisib
CAS No.: 1639417-53-0
Chemical Name: Tenalisib
Synonyms: RP6530;Tenalisib;RP6530, Tenalisib;Tenalisib (RP6530);Tenalisib, 10 mM in DMSO;RP-6530; RP 6530; RP6530;Tenalisib (RP6530) ，S8672;Tenalisib (Synonyms: RP6530);alpha-2,3-Sialyltransferase (PmST1);Tenalisib,RP 6530,PI3K,Phosphoinositide 3-kinase,RP-6530,Inhibitor,inhibit
CBNumber: CB43054293
Molecular Formula: C23H18FN5O2
Formula Weight: 415.42
MOL File: 1639417-53-0.mol

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Tenalisib Property

Boiling point:: 706.1±60.0 °C(Predicted)
Density: 1.434±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 100 mg/mL (240.72 mM)
form: Solid
pka: 10.06±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6375
Product name: Tenalisib
Purity: 98.94%
Packaging: 10mg
Price: $290
Updated: 2021/12/16

ChemScene

Product number: CS-6375
Product name: Tenalisib
Purity: 98.94%
Packaging: 25mg
Price: $500
Updated: 2021/12/16

ChemScene

Product number: CS-6375
Product name: Tenalisib
Purity: 98.94%
Packaging: 50mg
Price: $890
Updated: 2021/12/16

ChemScene

Product number: CS-6375
Product name: Tenalisib
Purity: 98.94%
Packaging: 100mg
Price: $1500
Updated: 2021/12/16

Crysdot

Product number: CD11241930
Product name: Tenalisib
Purity: 95+%
Packaging: 10mg
Price: $230
Updated: 2021/12/16

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Tenalisib Chemical Properties,Usage,Production

Uses

Tenalisib (RP6530) is a novel, potent, and selective PI3Kδ and PI3Kγ inhibitor with IC50 values of 25 and 33 nM, respectively.

in vivo

Tenalisib has been well tolerated in subjects with heavily pre-treated relapsed/refractory hematologic malignancies. Reported toxicities are manageable with no DLTs. Single agent activity is evident in difficult-to-treat subjects at ≥ 200 mg BID^[2].

IC 50

PI3Kδ: 25 nM (IC₅₀); PI3Kγ: 33 nM (IC₅₀)

References

[1] Vakkalanka S, et al. RP6530, a dual PI3K δ/γ inhibitor, potentiates ruxolitinib activity in the JAK2-V617F mutant erythroleukemia cell lines. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2704. doi:10.1158/1538-7445.AM2015-2704
[2] Carmelo C, et al. A Dose Escalation Study of RP6530, a Novel Dual PI3K Delta/Gamma Inhibitor, in Patients with Relapsed/Refractory Hematologic Malignancies. Blood 2015 126:1495;

Tenalisib Preparation Products And Raw materials

Raw materials

Preparation Products

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Tenalisib Suppliers

China 58 India 2 United States 5 Global 65

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
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Zhengzhou HSH Science & Technology Co., Ltd.

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Fax: 0086-0371-55932928
Email: 1282296214@qq.com
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ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185;
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Bide Pharmatech Ltd.

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Fax: +86-21-61629029
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Sichuan Wei Keqi Biological Technology Co., Ltd.

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Email: 3003855609@qq.com
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Shanghai Lollane Biological Technology Co.,Ltd.

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Fax: +86-21-52996696
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Shanghai YuanYe Biotechnology Co., Ltd.

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Shanghai Chaolan Chemical Technology Center

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Amadis Chemical Company Limited

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Email: sales@amadischem.com
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Kaixin Chemical (Hong Kong) Limited

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1639417-53-0, TenalisibRelated Search:

RP6530

Tenalisib

Tenalisib (RP6530)

RP6530, Tenalisib

Tenalisib (Synonyms: RP6530)

RP-6530; RP 6530; RP6530

4H-1-Benzopyran-4-one, 3-(3-fluorophenyl)-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-

(S)-2-(1-((9H-Purin-6-yl)amino)propyl)-3-(3-fluorophenyl)-4H-chromen-4-one

Tenalisib,RP 6530,PI3K,Phosphoinositide 3-kinase,RP-6530,Inhibitor,inhibit

Tenalisib, 10 mM in DMSO

Tenalisib (RP6530) ，S8672

alpha-2,3-Sialyltransferase (PmST1)

1639417-53-0