Boc-Val-Cit-PABA

Product Name: Boc-Val-Cit-PABA
CAS No.: 870487-09-5
Chemical Name: Boc-Val-Cit-PABA
Synonyms: Boc-Gly-Gly-Phe-Gly;Boc-Val-Cit-PAB-OH;tert-butyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate;Boc-Val-Cit-PABA;Pentanoicacid,2,6-dioxo-,methylester;Inhibitor,inhibit,ADC Linkers,Boc Val Cit PAB,BocValCitPAB,Antibody-drug conjugates linkers;(S)-2-[(S)-2-(Boc-amino)-3-methylbutanamido]-N-[4-(hydroxymethyl)phenyl]-5-ureidopentanamide;N-[(1,1-Dimethylethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide;L-Ornithinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-
CBNumber: CB43059339
Molecular Formula: C23H37N5O6
Formula Weight: 479.57
MOL File: 870487-09-5.mol

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Boc-Val-Cit-PABA Property

Boiling point:: 771.3±60.0 °C(Predicted)
Density: 1.209±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO : 100 mg/mL (208.52 mM; Need ultrasonic)
pka: 11.25±0.46(Predicted)
form: Solid
color: White to off-white
InChIKey: NTAKMIJAGHASRI-ROUUACIJSA-N
SMILES: C(N)(=O)[C@H](CCCNC(N)=O)N(C(=O)[C@H](C(C)C)NC(OC(C)(C)C)=O)C1=CC=C(CO)C=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-24174
Product name: Boc-Val-Cit-PAB
Purity: 95%
Packaging: 250mg
Price: $280
Updated: 2021/12/16

Iris Biotech GmbH

Product number: ADC1020
Product name: Boc-Val-Cit-PAB
Packaging: 250mg
Price: $303.75
Updated: 2021/12/16

ChemScene

Product number: CS-0114767
Product name: Boc-Val-Cit-PAB
Packaging: 100mg
Price: $362
Updated: 2021/12/16

BroadPharm

Product number: BP-24174
Product name: Boc-Val-Cit-PAB
Purity: 95%
Packaging: 500mg
Price: $480
Updated: 2021/12/16

BroadPharm

Product number: BP-24174
Product name: Boc-Val-Cit-PAB
Purity: 95%
Packaging: 1g
Price: $740
Updated: 2021/12/16

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Boc-Val-Cit-PABA Chemical Properties,Usage,Production

Description

Boc-Val-Cit-PAB is a cleavable ADC linker. The Val-Cit peptide will specifically be cleaved by Cathepsin B. Boc group can be removed under acidic condition.

Uses

Boc-Val-Cit-PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC 50

Protease Cleavable Linker; Cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

Boc-Val-Cit-PABA Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-Val-Cit-PABA Suppliers

China 92 United States 5 Global 97

Shenzhen Yuzhong Pharmaceutical Technology Co., Ltd.

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Heze Development Zone chuangli Chemical Co., Ltd.

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Shanghai Chaolan Chemical Technology Center

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View Lastest Price from Boc-Val-Cit-PABA manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Boc-Val-Cit-PAB 870487-09-5
Price: US $0.00/g
Min. Order: 5g
Purity: >99.00%
Supply Ability: 5g
Release date: 2024-03-29

870487-09-5, Boc-Val-Cit-PABARelated Search:

p-Aminobenzoesure-2-ethylhexylester 2-Ethylhexyl 4-dimethylaminobenzoate

Boc-Val-Cit-PABA

N-[(1,1-Dimethylethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide

Boc-Val-Cit-PAB-OH

(S)-2-[(S)-2-(Boc-amino)-3-methylbutanamido]-N-[4-(hydroxymethyl)phenyl]-5-ureidopentanamide

L-Ornithinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-

Boc-Gly-Gly-Phe-Gly

tert-butyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

Pentanoicacid,2,6-dioxo-,methylester

Inhibitor,inhibit,ADC Linkers,Boc Val Cit PAB,BocValCitPAB,Antibody-drug conjugates linkers

870487-09-5

C23H37N5O6

Linker

ADC LINKER

ADCs