MS37452

ChemicalBook > CAS DataBase List > MS37452

Product Name: MS37452
CAS No.: 423748-02-1
Chemical Name: MS37452
Synonyms: MS37452;1-(2,3-dimethoxybenzoyl)-4-[(3-methylphenoxy)acetyl]piperazine;1-(4-(2,3-Dimethoxybenzoyl)piperazin-1-yl)-2-(m-tolyloxy)ethanone;1-[4-(2,3-Dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)-ethanone;Ethanone, 1-[4-(2,3-dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)-;1-[4-(2,3-dimethoxybenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethan-1-one;MS 37452,Histone Methyltransferase,transcription,Inhibitor,MS37452,p16/CDKN2A,anticancer,H3K27me3,derepress,CBX7 chromodomain,inhibit,INK4A/ARF,MS-37452
CBNumber: CB43060612
Molecular Formula: C22H26N2O5
Formula Weight: 398.45224
MOL File: 423748-02-1.mol

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MS37452 Property

Boiling point:: 628.8±55.0 °C(Predicted)
Density: 1.209±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
form: powder
pka: -1.31±0.70(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1405
Product name: MS37452
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $142
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1405
Product name: MS37452
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $451
Updated: 2023/06/20

Cayman Chemical

Product number: 17533
Product name: MS37452
Purity: ≥98%
Packaging: 1mg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 17533
Product name: MS37452
Purity: ≥98%
Packaging: 5mg
Price: $111
Updated: 2024/03/01

Cayman Chemical

Product number: 17533
Product name: MS37452
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

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MS37452 Chemical Properties,Usage,Production

Description

Chromobox homolog 7 (CBX7) functions through its N-terminal chromodomain, which recognizes histone 3 trimethyl lysine 27 (H3K27me3), to repress gene transcription. It plays a key role in gene transcription in cellular processes related to stem cell self-renewal and differentiation, as well as tumor progression. MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (K_i = 43 μM). At 250 μM, it has been shown to derepress transcription of the polycomb repressive complex target gene p16/CDKN2A in prostate cancer cells.

Uses

MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 and has been shown to derepress transcription of the polycomb repressive complex target gene.

Biochem/physiol Actions

MS37452 is a selective Chromobox homolog 7 (CBX7) modulator that disrupts CBX7ChD binding to H3K27me3. MS37452 inhibits CBX7 binding to INK4/ARF gene locus, and induces decline of p14/ARF and p16/INK4a in human PC3 cells.

in vitro

in a previous study, the crystal structures revealed the binding modes of ms37452 and its close analogs that competed against h3k27me3 binding via interactions with key residues in the methyl-lysine binding pocket of cbx7chd. it was further found that ms37452 as the lead compound was able to derepress the transcription of polycomb repressive complex target gene p16/cdkn2a through displacing cbx7 binding to the ink4a/arf locus in prostate cancer cells. these findings showed that ms37452 and its close analogs had the potential to be developed into high-potency chemical modulators targeting cbx7 functions in gene transcription in various disease pathways [1].

References

[1] ren, c. ,morohashi, k.,plotnikov, a.n., et al. small-molecule modulators of methyl-lysine binding for the cbx7 chromodomain. chemistry & biology 22, 161-168 (2015).

MS37452 Preparation Products And Raw materials

Raw materials

Preparation Products

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423748-02-1, MS37452Related Search:

MS37452

1-(2,3-dimethoxybenzoyl)-4-[(3-methylphenoxy)acetyl]piperazine

Ethanone, 1-[4-(2,3-dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)-

1-(4-(2,3-Dimethoxybenzoyl)piperazin-1-yl)-2-(m-tolyloxy)ethanone

1-[4-(2,3-Dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)-ethanone

MS 37452,Histone Methyltransferase,transcription,Inhibitor,MS37452,p16/CDKN2A,anticancer,H3K27me3,derepress,CBX7 chromodomain,inhibit,INK4A/ARF,MS-37452

1-[4-(2,3-dimethoxybenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethan-1-one

423748-02-1