Azido-PEG6-PFP ester

Product Name: Azido-PEG6-PFP ester
CAS No.: 1818294-47-1
Chemical Name: Azido-PEG6-PFP ester
Synonyms: N3-PEG6-CH2CH2COOPFP;Azido-PEG6-PFP ester;Perfluorophenyl 1-azido-3,6,9,12,15,18-hexaoxahenicosan-21-oate;(2,3,4,5,6-pentafluorophenyl) 3-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
CBNumber: CB43062368
Molecular Formula: C21H28F5N3O8
Formula Weight: 545.46
MOL File: 1818294-47-1.mol

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Azido-PEG6-PFP ester Property

solubility: Soluble in DCM

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-21864
Product name: Azido-PEG6-PFPester
Purity: 98%
Packaging: 100mg
Price: $280
Updated: 2021/12/16

Apolloscientific

Product number: BIPG1166
Product name: Azido-PEG6-PFP ester
Packaging: 100mg
Price: $546
Updated: 2021/12/16

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Azido-PEG6-PFP ester Chemical Properties,Usage,Production

Description

Azido-PEG6-PFP ester is a a high purity PEG linker containing azide and PFP ester moities. The azide can participate in Click Chemistry reactions with alkynes, such as DBCO and BCN to form triazole groups. The PFP ester is amine-reactive and is less susceptible toward hydrolysis compared to NHS ester.

Uses

Azido-PEG6-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG6-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Azido-PEG6-PFP ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Azido-PEG6-PFP ester Suppliers

China 24 United Kingdom 1 United States 2 Global 27

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

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Jinan elephant international trading co., LTD

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Amatek Scientific Co. Ltd.

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SuZhou Medinoah Co.,LTD.

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Alpha Biopharmaceuticals Co., Ltd

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TargetMol Chemicals Inc.

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Nextpeptide Inc

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Shaanxi Xinyan Bomei Biotechnology Co., Ltd.

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Chongqing Chemdad Co., Ltd

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Zhengzhou Akem Chemical Co., Ltd

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1818294-47-1, Azido-PEG6-PFP esterRelated Search:

Azido-PEG6-PFP ester

(2,3,4,5,6-pentafluorophenyl) 3-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate

N3-PEG6-CH2CH2COOPFP

Perfluorophenyl 1-azido-3,6,9,12,15,18-hexaoxahenicosan-21-oate

1818294-47-1

C21H28F5N3O8