Fmoc-N-methyl-N-amido-PEG2-acid
- Product Name
- Fmoc-N-methyl-N-amido-PEG2-acid
- CAS No.
- 1807518-77-9
- Chemical Name
- Fmoc-N-methyl-N-amido-PEG2-acid
- Synonyms
- Fmoc-NMe-PEG3-acid;Fmoc-NMe-PEG2-acid;Fmoc-MeN-PEG3-CH2CH2COOH;Fmoc-N-Me-PEG3-CH2CH2COOH;Fmoc-N-methyl-PEG3-CH2CH2COOH;Fmoc-N-methyl-N-amido-PEG2-COOH;Fmoc-N-methyl-N-amido-PEG2-acid;5,8,11-Trioxa-2-azatetradecanedioic acid, 2-methyl-, 1-(9H-fluoren-9-ylmethyl) ester
- CBNumber
- CB43062500
- Molecular Formula
- C25H31NO7
- Formula Weight
- 457.52
- MOL File
- 1807518-77-9.mol
Fmoc-N-methyl-N-amido-PEG2-acid Property
- Boiling point:
- 630.5±55.0 °C(Predicted)
- Density
- 1.218±0.06 g/cm3(Predicted)
- solubility
- Soluble in DMSO, DCM, DMF
- pka
- 4.28±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- HXC51877
- Product name
- Fmoc-nme-PEG2-acid
- Packaging
- 250mg
- Price
- $1035
- Updated
- 2026/06/04
- Product number
- HXC51877
- Product name
- Fmoc-nme-PEG2-acid
- Packaging
- 500mg
- Price
- $1440
- Updated
- 2026/06/04
- Product number
- CS-0086440
- Product name
- Fmoc-N-methyl-PEG3-CH2CH2COOH
- Purity
- ≥97%
- Packaging
- 1g
- Price
- $2419
- Updated
- 2026/06/04
- Product number
- CS-0086440
- Product name
- Fmoc-N-methyl-PEG3-CH2CH2COOH
- Purity
- ≥97%
- Packaging
- 1g
- Price
- $2419
- Updated
- 2026/06/04
- Product number
- BIPG1414
- Product name
- Fmoc-N-methyl-N-amido-PEG2-acid
- Purity
- 98%
- Packaging
- 100mg
- Price
- $645
- Updated
- 2026/06/04
Fmoc-N-methyl-N-amido-PEG2-acid Chemical Properties,Usage,Production
Description
Fmoc-N-methyl-N-amido-PEG2-acid is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Uses
Fmoc-N-methyl-PEG3-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-N-methyl-PEG3-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
Cleavable Linker; Alkyl/ether; PEGs
References
[1] Yang Y,et al. Design, synthesis, and biological characterization of novel PEG-linked dimeric modulators for CXCR4. Bioorg Med Chem. 2016 Nov 1;24(21):5393-5399. DOI:10.1016/j.bmc.2016.08.062
Fmoc-N-methyl-N-amido-PEG2-acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Fmoc-N-methyl-N-amido-PEG2-acid manufacturers
- Product
- Fmoc-NMe-PEG3-acid 1807518-77-9
- Price
- US $0.00/mg
- Min. Order
- 500mg
- Purity
- >98.00%
- Supply Ability
- 500mg
- Release date
- 2024-03-25