5-Bromo-3-iodopyrazin-2-amine
- Product Name
- 5-Bromo-3-iodopyrazin-2-amine
- CAS No.
- 1062608-42-7
- Chemical Name
- 5-Bromo-3-iodopyrazin-2-amine
- Synonyms
- 5-Bromo-3-iodopyrazin-2-amine;2-Amino-5-bromo-3-iodopyrazine;2-amino-3-iodo-5-bromo-pyrazine;2-Pyrazinamine, 5-bromo-3-iodo-;5-Bromo-3-iodo-pyrazin-2-ylamine
- CBNumber
- CB43065329
- Molecular Formula
- C4H3BrIN3
- Formula Weight
- 299.9
- MOL File
- 1062608-42-7.mol
5-Bromo-3-iodopyrazin-2-amine Property
- Boiling point:
- 353.7±42.0 °C(Predicted)
- Density
- 2.576±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 0.84±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- B679773
- Product name
- 5-Bromo-3-iodopyrazin-2-amine
- Packaging
- 100mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- A256223
- Product name
- 5-Bromo-3-iodopyrazin-2-amine
- Purity
- 95%
- Packaging
- 100mg
- Price
- $49
- Updated
- 2021/12/16
- Product number
- A256223
- Product name
- 5-Bromo-3-iodopyrazin-2-amine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- AA10-1429
- Product name
- 5-Bromo-3-iodo-pyrazin-2-ylamine
- Purity
- ＞95%
- Packaging
- 1g
- Price
- $195
- Updated
- 2021/12/16
- Product number
- A256223
- Product name
- 5-Bromo-3-iodopyrazin-2-amine
- Purity
- 95%
- Packaging
- 1g
- Price
- $199
- Updated
- 2021/12/16
5-Bromo-3-iodopyrazin-2-amine Chemical Properties,Usage,Production
Synthesis
59489-71-3
1062608-42-7
General procedure for the synthesis of 5-bromo-3-iodopyrazin-2-amine from 2-amino-5-bromopyrazine: To a solution of 2-amino-5-bromopyrazine (10.0 g, 57.47 mmol) in 1,4-dioxane (100 mL) was added N-iodosuccinimide (15.5 g, 68.96 mmol). The reaction mixture was heated to 80 °C and kept for 16 h. After cooling to room temperature, the 1,4-dioxane was removed by concentration under reduced pressure by rotary evaporator. To the residue, 50 mL of water was added and extracted with dichloromethane (50 mL x 4), the organic phases were combined and washed with distilled water (20 mL x 3), dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain the crude product. The crude product was purified by fast column chromatography with the eluent being a petroleum ether solution of 20-30% ethyl acetate to give the final target compound 5-bromo-3-iodopyrazin-2-amine (4.3 g, 25.1% yield).1H NMR (400 MHz, DMSO-d6): δ 8.05 (s, 1H), 6.76 (s, 2H).
References
[1] Journal of Medicinal Chemistry, 2013, vol. 56, # 21, p. 8860 - 8871
[2] Patent: WO2017/9773, 2017, A1. Location in patent: Page/Page column 19
[3] Patent: WO2013/121387, 2013, A1. Location in patent: Page/Page column 30
5-Bromo-3-iodopyrazin-2-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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