5-Chloropyrazolo[1,5-a]pyrimidin-7(1H)-one
- Product Name
- 5-Chloropyrazolo[1,5-a]pyrimidin-7(1H)-one
- CAS No.
- 99898-84-7
- Chemical Name
- 5-Chloropyrazolo[1,5-a]pyrimidin-7(1H)-one
- Synonyms
- 5-chloropyrazolo<1,5-a>pyrimidin-7-one;5-Chloropyrazolo[1,5-a]pyrimidin-7(1H)-one;Pyrazolo[1,5-a]pyrimidin-7(4H)-one, 5-chloro-
- CBNumber
- CB43065415
- Molecular Formula
- C6H4ClN3O
- Formula Weight
- 169.57
- MOL File
- 99898-84-7.mol
5-Chloropyrazolo[1,5-a]pyrimidin-7(1H)-one Property
- Melting point:
- 298-300 °C (decomp)
- Boiling point:
- 302.4±52.0 °C(Predicted)
- Density
- 1.71±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.58±0.40(Predicted)
- form
- solid
- Appearance
- White to off-white Solid
- InChI
- 1S/C6H4ClN3O/c7-4-3-6(11)10-5(9-4)1-2-8-10/h1-3,9H
- InChIKey
- QNNBWYYLICBZOI-UHFFFAOYSA-N
Safety
- WGK Germany
- WGK 3
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Aquatic Chronic 1
Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0060099
- Product name
- 5-Chloropyrazolo(1,5-a)pyrimidin-7-one
- Packaging
- 1g
- Price
- $405
- Updated
- 2021/12/16
- Product number
- CS-0060099
- Product name
- 5-Chloropyrazolo(1,5-a)pyrimidin-7-one
- Packaging
- 250mg
- Price
- $162
- Updated
- 2021/12/16
- Product number
- CS-0060099
- Product name
- 5-Chloropyrazolo(1,5-a)pyrimidin-7-one
- Packaging
- 100mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- CS-0060099
- Product name
- 5-Chloropyrazolo(1,5-a)pyrimidin-7-one
- Packaging
- 5g
- Price
- $1747
- Updated
- 2021/12/16
- Product number
- A199843
- Product name
- 5-Chloropyrazolo[1,5-a]pyrimidin-7(1H)-one
- Purity
- 95%
- Packaging
- 100mg
- Price
- $105
- Updated
- 2021/12/16
5-Chloropyrazolo[1,5-a]pyrimidin-7(1H)-one Chemical Properties,Usage,Production
Synthesis
57489-77-7
99898-84-7
General procedure for the synthesis of 5-chloropyrazolo[1,5-a]pyrimidin-7(1H)-ones from 5,7-dichloropyrazolo[1,5-a]pyrimidines: 1 g of 5,7-dichloropyrazolo[1,5-a]pyrimidines was suspended in 25 mL of 1 N aqueous sodium hydroxide solution, heated to 90 °C and stirred for 0.5 h. The reaction was carried out by thin layer chromatography (TLC). The progress of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, the reaction mixture was cooled to room temperature. The pH was adjusted to 2 with 1N HCl solution to form a suspension. 5-Chloropyrazolo[1,5-a]pyrimidin-7(1H)-one (0.9 g, 99% yield) was obtained by filtration after standing.
References
[1] Patent: CN107033149, 2017, A. Location in patent: Paragraph 0110; 0180-0181
[2] Journal of Heterocyclic Chemistry, 1985, vol. 22, # 3, p. 601 - 634
5-Chloropyrazolo[1,5-a]pyrimidin-7(1H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
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