3-(4-BROMOPHENYL)-1-METHYLPYRROLIDINE

Product Name: 3-(4-BROMOPHENYL)-1-METHYLPYRROLIDINE
CAS No.: 1088410-99-4
Chemical Name: 3-(4-BROMOPHENYL)-1-METHYLPYRROLIDINE
Synonyms: 3-(4-BROMOPHENYL)-1-METHYLPYRROLIDINE;Pyrrolidine, 3-(4-bromophenyl)-1-methyl-
CBNumber: CB43067161
Molecular Formula: C11H14BrN
Formula Weight: 240.14
MOL File: 1088410-99-4.mol

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3-(4-BROMOPHENYL)-1-METHYLPYRROLIDINE Property

Boiling point:: 283.8±33.0 °C(Predicted)
Density: 1.333±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 9.91±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B998078
Product name: 3-(4-Bromophenyl)-1-methylpyrrolidine
Packaging: 50mg
Price: $150
Updated: 2021/12/16

Ambeed

Product number: A128594
Product name: 3-(4-Bromophenyl)-1-methylpyrrolidine
Purity: 95%
Packaging: 100mg
Price: $207
Updated: 2021/12/16

Ambeed

Product number: A128594
Product name: 3-(4-Bromophenyl)-1-methylpyrrolidine
Purity: 95%
Packaging: 250mg
Price: $311
Updated: 2021/12/16

Crysdot

Product number: CD11354387
Product name: 3-(4-Bromophenyl)-1-methylpyrrolidine
Purity: 95+%
Packaging: 250mg
Price: $325
Updated: 2021/12/16

Alichem

Product number: 1088410994
Product name: 3-(4-Bromophenyl)-1-methylpyrrolidine
Packaging: 1g
Price: $601.07
Updated: 2021/12/16

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3-(4-BROMOPHENYL)-1-METHYLPYRROLIDINE Chemical Properties,Usage,Production

Uses

3-(4-Bromophenyl)-1-Methylpyrrolidine (cas# 1088410-99-4) is a useful reagent for the preparation of pyrazolopyrimidines for treatment and prevention of ALK2-mediated diseases.

Synthesis

50-00-0

328546-98-1

1088410-99-4

The general procedure for the synthesis of 3-(4-bromophenyl)-1-methylpyrrolidine from formaldehyde and the compound (CAS:328546-98-1) was as follows: referring to the method of Example 11, formalin (0.0452 mL, 0.557 mmol), acetic acid (0.0319 mL, 0.557 mmol) and triacetoxyborohydride (118 mg , 0.557 mmol) were added to a chloroform-ethanol (3:1, 2 mL) solvent mixture containing 3-(4-bromophenyl)pyrrolidine (42 mg, 0.186 mmol). The reaction mixture was stirred at room temperature for 40 min. After completion of the reaction, the reaction solution was diluted with ethyl acetate and the diluted solution was washed with 10% aqueous sodium bicarbonate. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 43 mg of the title compound in 97% yield. The product was analyzed by mass spectrometry (GC) at m/z 239 [M]+, 1H-NMR (400 MHz, CDCl3) δ: 1.71-1.88 (1H, m), 2.29-2.50 (5H, m), 2.61-2.69 (1H, m), 2.72-2.80 (1H, m), 2.94-3.00 (1H, m), 3.28 -3.38 (1H, m), 7.15 (2H, d, J = 8.3 Hz), 7.40 (2H, d, J = 8.3 Hz).

References

[1] Patent: EP2166015, 2010, A1. Location in patent: Page/Page column 28

3-(4-BROMOPHENYL)-1-METHYLPYRROLIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(4-BROMOPHENYL)-1-METHYLPYRROLIDINE Suppliers

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1088410-99-4, 3-(4-BROMOPHENYL)-1-METHYLPYRROLIDINERelated Search:

(2S)-2-(4-BROMOPHENYL)PYRROLIDINE HCl 3-(3-BroMophenyl)pyrrolidine hcl 2-(2,4-DIFLUORO-PHENYL)-PYRROLIDINE HYDROCHLORIDE 1-((2S)PYRROLIDIN-2-YL)-4-METHOXYBENZENE HCl (R)-2-(4-(TRIFLUOROMETHYL)PHENYL)PYRROLIDINE HYDROCHLORIDE 3-((2S)PYRROLIDIN-2-YL)-1-METHOXYBENZENE HYDROCHLORIDE 3-(2-Bromophenyl)pyrrolidine hydrochloride (2S)-2-(4-CHLOROPHENYL)PYRROLIDINE HCL (S)-tert-butyl 2-(4-bromophenyl)pyrrolidine-1-carboxylate 3-(4-BroMophenyl)pyrrolidine hydrochloride 1-Pyrrolidinecarboxylic acid, 2-(4-bromophenyl)-, 1,1-dimethylethyl ester, (2R)- 2-(4-(TRIFLUOROMETHYL)PHENYL)PYRROLIDINE HCL (2R)-2-(4-CHLOROPHENYL)PYRROLIDINE HCL 3-(4-METHOXYPHENYL)MORPHOLINE HYDROCHLORIDE 3-(3,4-Dichlorophenyl)pyrrolidine hydrochloride (R)-2-(4-METHOXYPHENYL)PYRROLIDINE HYDROCHLORIDE

3-(4-BROMOPHENYL)-1-METHYLPYRROLIDINE

Pyrrolidine, 3-(4-bromophenyl)-1-methyl-

1088410-99-4