3-Bromo-6-fluoro-2-methyl-benzoic acid

Product Name: 3-Bromo-6-fluoro-2-methyl-benzoic acid
CAS No.: 1427373-55-4
Chemical Name: 3-Bromo-6-fluoro-2-methyl-benzoic acid
Synonyms: 3-Bromo-6-fluoro-2-methyl-benzoic acid;Benzoic acid, 3-bromo-6-fluoro-2-methyl-
CBNumber: CB43067510
Molecular Formula: C8H6BrFO2
Formula Weight: 233.03
MOL File: 1427373-55-4.mol

More

Less

3-Bromo-6-fluoro-2-methyl-benzoic acid Property

Boiling point:: 307.2±42.0 °C(Predicted)
Density: 1.680±0.06 g/cm3(Predicted)
storage temp.: Store at room temperature
form: crystalline solid
pka: 2.57±0.31(Predicted)
color: White

More

Less

Safety

HS Code: 2916399090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B683125
Product name: 3-Bromo-6-fluoro-2-methylbenzoicAcid
Packaging: 5g
Price: $2205
Updated: 2021/12/16

ChemScene

Product number: CS-0047306
Product name: 3-Bromo-6-fluoro-2-methylbenzoicacid
Packaging: 5g
Price: $2191
Updated: 2021/12/16

AK Scientific

Product number: 0239EA
Product name: 3-Bromo-6-fluoro-2-methylbenzoicacid
Packaging: 250mg
Price: $399
Updated: 2021/12/16

ChemScene

Product number: CS-0047306
Product name: 3-Bromo-6-fluoro-2-methylbenzoicacid
Packaging: 1g
Price: $730
Updated: 2021/12/16

Alichem

Product number: 1427373554
Product name: 3-Bromo-6-fluoro-2-methylbenzoicacid
Packaging: 500mg
Price: $839.45
Updated: 2021/12/16

More

Less

3-Bromo-6-fluoro-2-methyl-benzoic acid Chemical Properties,Usage,Production

Uses

3-Bromo-6-fluoro-2-methylbenzoic Acid acts as a reagent for the preparation of aryl and heteroaryl fused lactams as antitumor agents.

Synthesis

90259-27-1

1427373-55-4

General procedure for the synthesis of 3-bromo-6-fluoro-2-methylbenzoic acid from 2-fluoro-6-methylbenzoic acid: 2-fluoro-6-methylbenzoic acid (1.48 g, 9.60 mmol) was dissolved in a mixture of concentrated hydrochloric and sulfuric acids (40 mL) at 0 °C. Subsequently, N-bromosuccinimide (NBS, 1.79 g, 10.1 mmol) was added to this solution. The reaction mixture was stirred continuously at 0 °C for 3 hours. After completion of the reaction, the mixture was poured into ice water (200 mL) and extracted with ether (2 x 200 mL). The organic phases were combined, dried with anhydrous sodium sulfate and subsequently concentrated under reduced pressure to afford the target product 3-bromo-6-fluoro-2-methylbenzoic acid (Compound QQ, 2.15 g, 96% yield) as a solid. The structure of the product was confirmed by 1H NMR (400 MHz, chloroform-d): δ 7.64 (dd, J = 8.84,5.31 Hz, 1H), 6.92 (t, J = 8.84 Hz, 1H), 2.54 (s, 3H); mass spectrometry (MS) showed the molecular ion peak [M + H]+ as 231.0.

References

[1] Patent: US2014/179667, 2014, A1. Location in patent: Paragraph 0816; 0817
[2] Patent: WO2013/37705, 2013, A2. Location in patent: Page/Page column 143
[3] Patent: WO2014/33170, 2014, A1. Location in patent: Page/Page column 99; 100
[4] Patent: WO2014/33176, 2014, A1. Location in patent: Page/Page column 99-100

3-Bromo-6-fluoro-2-methyl-benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

3-Bromo-6-fluoro-2-methyl-benzoic acid Suppliers

China 47 India 2 United States 5 Global 54

Xinyanhe Pharmatech Co.,Ltd

Tel: 0519-85252752 15366845260
Fax: 86-0519-85683352
Email: taihuaren@vip.163.com
Country: China
ProdList: 1118
Advantage: 58

Quzhou AMK BioTech Co., Ltd

Tel: 0570-3081766 18357083060
Fax: 0570-3072337
Email: sales@qzamkbio.com
Country: China
ProdList: 1111
Advantage: 55

Shanghai Brain Biotechnology Co., Ltd.

Tel: 13564638271
Email: shhjiang1977@163.com
Country: China
ProdList: 2989
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shanghai Anmike Chemical Co. Ltd.

Tel: 微信 17321281695 18019252918
Fax: 021-31261685
Email: sale@amkchem.com
Country: China
ProdList: 9991
Advantage: 55

Nanijing m&m biotechnology Co. ,Ltd.

Tel: 025-87782433 18021532344
Fax: 025-87782433
Email: 1345332203@qq.com
Country: China
ProdList: 4158
Advantage: 58

Cochemical Ltd.

Tel: 029-86115547 17791676824
Fax: 021-51602123
Email: sales@cochemical.com
Country: China
ProdList: 4104
Advantage: 58

Aikon International Limited

Tel: 025-66061636 18013972705
Fax: (3)02557626880
Email: qqyang@aikonchem.com
Country: China
ProdList: 15813
Advantage: 58

Suzhou Xiya Pharmaceutical Co., Ltd.

Tel: 0512-87819718 18912655635
Email: 2587879032@qq.com
Country: China
ProdList: 1378
Advantage: 58

Fuxin Crest Biotechnology Co. Ltd.

Tel: 13062833949
Fax: QQ: 2073772974
Email: fred.wen@crcorporation.cn
Country: China
ProdList: 853
Advantage: 58

1427373-55-4, 3-Bromo-6-fluoro-2-methyl-benzoic acidRelated Search:

3-Bromo-6-fluoro-2-methyl-benzoic acid

Benzoic acid, 3-bromo-6-fluoro-2-methyl-

1427373-55-4