(E)-2-cyano-3-cyclopropylacrylic acid
- Product Name
- (E)-2-cyano-3-cyclopropylacrylic acid
- CAS No.
- 98895-60-4
- Chemical Name
- (E)-2-cyano-3-cyclopropylacrylic acid
- Synonyms
- Acetonitrile,2,4'-(nitrosoimino)bis-;(E)-2-cyano-3-cyclopropylacrylic acid;2-cyano-3-cyclopropylprop-2-enoic acid;2-Propenoic acid, 2-cyano-3-cyclopropyl-;2-Thiazolamine,4-(4-methoxyphenyl)-9-methyl-;(E)-2-cyano-3-cyclopropylacrylic acid98895-60-4
- CBNumber
- CB43082384
- Molecular Formula
- C7H7NO2
- Formula Weight
- 137.14
- MOL File
- 98895-60-4.mol
(E)-2-cyano-3-cyclopropylacrylic acid Property
- Boiling point:
- 325.6±25.0 °C(Predicted)
- Density
- 1.467±0.06 g/cm3(Predicted)
- pka
- 1.77±0.19(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B423988
- Product name
- 2-cyano-3-cyclopropylacrylicacid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 6052DW
- Product name
- 2-Cyano-3-cyclopropylacrylicacid
- Packaging
- 100mg
- Price
- $209
- Updated
- 2021/12/16
- Product number
- 6052DW
- Product name
- 2-Cyano-3-cyclopropylacrylicacid
- Packaging
- 250mg
- Price
- $273
- Updated
- 2021/12/16
- Product number
- CM256073
- Product name
- 2-Cyano-3-cyclopropylacrylicacid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $387
- Updated
- 2021/12/16
- Product number
- 6583441
- Product name
- 2-Cyano-3-cyclopropylprop-2-enoicacid
- Purity
- 95%
- Packaging
- 5G
- Price
- $1000
- Updated
- 2021/12/16
(E)-2-cyano-3-cyclopropylacrylic acid Chemical Properties,Usage,Production
Synthesis
372-09-8
1489-69-6
98895-60-4
2.6.6 Synthesis of 2-cyano-3-cyclopropylpropenoic acid (23): To a solution of cyclopropanecarboxaldehyde (0.36 g, 5.25 mmol) in anhydrous toluene (10 mL) under anhydrous conditions were sequentially added cyanoacetic acid (0.44 g, 5.25 mmol), piperidine (1.0 mL, 10.5 mmol) and glacial acetic acid (1.2 mL, 20.9 mmol). The reaction mixture was stirred in an oil bath at 80 °C for 2 h and subsequently cooled to room temperature. After completion of the reaction, the excess solvent was removed by rotary evaporator under reduced pressure. The residue was dissolved in ethyl acetate (20 mL) and the organic layer was washed sequentially with 1 M aqueous hydrochloric acid (10 mL) and deionized water (10 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated to obtain the crude product. The crude product was purified by silica gel column chromatography with dichloromethane/methanol (98/2, v/v) as eluent, and the target component was collected and concentrated to give 2-cyano-3-cyclopropylpropenoic acid (23) 0.35 g as a white solid in 49% (2.55 mmol) yield.
References
[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 12, p. 2767 - 2780
(E)-2-cyano-3-cyclopropylacrylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
(E)-2-cyano-3-cyclopropylacrylic acid Suppliers
- Tel
- 0532-0532-88191853 13061484198
- Fax
- +86-532-88191853
- sales@carelongchem.com
- Country
- China
- ProdList
- 437
- Advantage
- 57
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 42446
- Advantage
- 60
- Tel
- 18-086626237 18086626237
- Fax
- qq:2693528373
- 2693528373@qq.com
- Country
- China
- ProdList
- 2973
- Advantage
- 56
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 86-0573-85866609 13325730825
- Fax
- 0573-85866609
- 945717149@qq.com
- Country
- China
- ProdList
- 8594
- Advantage
- 58
- Tel
- 021-61469567 13482353728
- Fax
- 021-61161605
- sales@fdc-chemical.com
- Country
- China
- ProdList
- 8840
- Advantage
- 58
- Tel
- 微信 17321281695 18019252918
- Fax
- qq:1454668768
- 1454668768@qq.com
- Country
- China
- ProdList
- 14856
- Advantage
- 58
- Tel
- 13969155946
- 1461866103@qq.com
- Country
- China
- ProdList
- 16111
- Advantage
- 58
- Tel
- 024-23982345
- 1020788318@qq.com
- Country
- China
- ProdList
- 2251
- Advantage
- 58
- Tel
- 021-20432219 13918097649
- Fax
- QQ79021576
- li_jinfei@acblock-lab.com
- Country
- China
- ProdList
- 10034
- Advantage
- 58