ChemicalBook > CAS DataBase List > "(R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide "

"(R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide "

Product Name: "(R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide "
CAS No.: 953778-63-7
Chemical Name: "(R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide "
Synonyms: TTA-A2;TTA-A2, 10 mM in DMSO;(R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamid;Benzeneacetamide, 4-cyclopropyl-N-[(1R)-1-[5-(2,2,2-trifluoroethoxy)-2-pyridinyl]ethyl]-;2-(4-cyclopropylphenyl)-N-[(1R)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl]acetamide;"(R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide ";Pregnane X receptor,TTA-A2,neurological diseases,T-type calcium channel,Inhibitor,Ca2+ channels,Ca channels,Electrocorticogram,TTAA2,sleep disorders,TTA-A-2,inhibit,TTA A2,Epilepsy,Calcium Channel
CBNumber: CB43120851
Molecular Formula: C20H21F3N2O2
Formula Weight: 378.39
MOL File: 953778-63-7.mol

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"(R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide " Property

Boiling point:: 538.5±50.0 °C(Predicted)
Density: 1.258±0.06 g/cm3(Predicted)
solubility: DMSO: Soluble: =10 mg/ml
Ethanol: Soluble: =10 mg/ml
form: Solid
pka: 14.29±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0093037
Product name: TTA-A2
Purity: ≥99.0%
Packaging: 1mg
Price: $250
Updated: 2021/12/16

Crysdot

Product number: CD11004405
Product name: (R)-2-(4-Cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide
Purity: 97%
Packaging: 100mg
Price: $980
Updated: 2021/12/16

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"(R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide " Chemical Properties,Usage,Production

Uses

TTA-A2 is a potent, selective and orally active t-type voltage gated calcium channel antagonist with reduced pregnane X receptor (PXR) activation. TTA-A2 is equally potent against the Cav3.1 (a1G) and Cav3.2 (a1H) channels with IC50 values of 89 nM and 92 nM, respectively, at -80 and -100 mV holding potentials. TTA-A2 can be used for the research of a variety of human neurological diseases, including sleep disorders and epilepsy[1][2].

in vivo

TTA-A2 (oral gavage; 3 mg/kg; single dose) produces significant changes in sleep architecture in rats. A reduction in active wake soon after dosing with a concurrent increase in delta sleep and decrease in REM sleep. Additionally, these effects persists for up to 4 h post-dose in rats^[1].TTA-A2 (oral gavage; 10 mg/kg; once daily; 5 days) shows selective effect on recurrent thalamocortical network activity, it suppresses active wake and promotes slow-wave sleep in wild-type mice but not in mice lacking both Cav3.1 and Cav3.3^[2].

Animal Model:	Wild-type and double Cav3.1/Cav3.3 knockout C57BL6/Sv129 background mices^[2]
Dosage:	10?mg/kg
Administration:	Oral gavage; 10?mg/kg; once daily; 5 days
Result:	Blocked active wake and promotes slow-wave sleep in wild-type mice but not mutant mice.

IC 50

T-type calcium channel

References

[1] Thomas S Reger, et al.Pyridyl amides as potent inhibitors of T-type DOI:10.1016/j.bmcl.2011.01.089

[2] Richard L Kraus, et al.In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice. J Pharmacol Exp Ther. 2010 Nov;335(2):409-17. DOI:10.1124/jpet.110.171058
[3] NEEMA KUMARI Subha N R Anamika Bhargava. T-type calcium channel antagonist, TTA-A2 exhibits anti-cancer properties in 3D spheroids of A549, a lung adenocarcinoma cell line[J]. Life sciences, 2020, 260: Article 118291. DOI: 10.1016/j.lfs.2020.118291

[4] VICTOR N UEBELE. Antagonism of T-type calcium channels inhibits high-fat diet-induced weight gain in mice.[J]. The Journal of clinical investigation, 2009: 1659-1667. DOI: 10.1172/jci36954

[5] JASON M. USLANER . T-type calcium channel antagonism produces antipsychotic-like effects and reduces stimulant-induced glutamate release in the nucleus accumbens of rats[J]. Neuropharmacology, 2012, 62 3: Pages 1413-1421. DOI: 10.1016/j.neuropharm.2010.11.015

[6] MARC CHEVALIER. T-type calcium channels are involved in hypoxic pulmonary hypertension.[J]. Cardiovascular Research, 2014, 103 4: 597-606. DOI: 10.1093/cvr/cvu166

"(R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide " Preparation Products And Raw materials

Raw materials

Preparation Products

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953778-63-7, "(R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide "Related Search:

"(R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide "

TTA-A2

(R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamid

2-(4-cyclopropylphenyl)-N-[(1R)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl]acetamide

Benzeneacetamide, 4-cyclopropyl-N-[(1R)-1-[5-(2,2,2-trifluoroethoxy)-2-pyridinyl]ethyl]-

Pregnane X receptor,TTA-A2,neurological diseases,T-type calcium channel,Inhibitor,Ca2+ channels,Ca channels,Electrocorticogram,TTAA2,sleep disorders,TTA-A-2,inhibit,TTA A2,Epilepsy,Calcium Channel

TTA-A2, 10 mM in DMSO

953778-63-7