ILK-IN-2

Product Name: ILK-IN-2
CAS No.: 2070015-22-2
Chemical Name: ILK-IN-2
Synonyms: ILK-IN-2;OSU-T315 ，S6840;OSU-T315 (ILK-IN-1);OSU-T315, 10 mM in DMSO;OSU-T315 (1,3-regioisomer);OSU-T315 (1,5-regioisomer);Inhibitor,Integrin,OSU-T315,OSU-T-315,Apoptosis,inhibit,Autophagy,OSU T315,OSUT315;1H-Pyrazole-5-propanamide, N-methyl-1-[4-(1-piperazinyl)phenyl]-3-[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-;N-Methyl-3-(1-(4-(piperazin-1-yl)phenyl)-3-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-5-yl)propanamide
CBNumber: CB43121106
Molecular Formula: C30H30F3N5O
Formula Weight: 533.59
MOL File: 2070015-22-2.mol

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ILK-IN-2 Property

storage temp.: 2-8°C(protect from light)
solubility: DMSO: ≥ 50 mg/mL (93.70 mM); Water: < 0.1 mg/mL (insoluble)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 6185EF
Product name: Ilk-IN-2
Packaging: 10mg
Price: $222
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611902
Product name: ILK-IN-2
Purity: >98%
Packaging: 100mg
Price: $986
Updated: 2021/12/16

ChemScene

Product number: CS-4936
Product name: OSU-T315
Purity: 99.88%
Packaging: 50mg
Price: $1300
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611902
Product name: ILK-IN-2
Purity: >98%
Packaging: 250mg
Price: $1802
Updated: 2021/12/16

AK Scientific

Product number: 6185EF
Product name: Ilk-IN-2
Packaging: 100mg
Price: $637
Updated: 2021/12/16

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ILK-IN-2 Chemical Properties,Usage,Production

Uses

OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain)[1]. OSU-T315 abrogates AKT activation by impeding AKT localization in lipid rafts and triggers caspase-dependent apoptosis in an ILK-independent manner[2]. OSU-T315 causes cell death through apoptosis and autophagy[1].

in vivo

OSU-T315 (Oral gavage; 25 mg/kg, 50 mg/kg; single daily; 35 days) has a suppressive effect of on PC-3 xenograft tumor growth ^[1].
No other obvious toxicity is observed in mice^[1].

Animal Model:	Male NCr athymic nude mice with PC-3 tumor xenografts
Dosage:	25 mg/kg; 50 mg/kg
Administration:	Oral gavage; single daily; 35 days
Result:	Resulted in suppression of tumor growth relative to the vehicle control after 35 days of treatment (48% and 62% suppression for 25 and 50 mg/kg, respectively).

References

[1] Su-Lin Lee,et al Identification and Characterization of a Novel Integrin-Linked Kinase Inhibitor.J Med Chem. 2011 Sep 22; 54(18): 6364–6374 DOI:10.1021/jm2007744
[2] Liu TM, et al. OSU-T315: a novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cells. Blood. 2015 Jan 8;125(2):284-95. DOI:10.1182/blood-2014-06-583518

ILK-IN-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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ILK-IN-2 Suppliers

China 44 United States 5 Global 49

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7777
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Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
Advantage: 55

Shanghai Beckham Medical Technology Co., Ltd

Tel: 13816613772
Fax: QQ: 12922499
Email: huahero21@sina.com
Country: China
ProdList: 2519
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
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Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9505
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Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
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Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32467
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InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

2070015-22-2, ILK-IN-2Related Search:

ILK-IN-2

OSU-T315 (1,5-regioisomer)

1H-Pyrazole-5-propanamide, N-methyl-1-[4-(1-piperazinyl)phenyl]-3-[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-

OSU-T315 (ILK-IN-1)

OSU-T315 (1,3-regioisomer)

N-Methyl-3-(1-(4-(piperazin-1-yl)phenyl)-3-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-5-yl)propanamide

Inhibitor,Integrin,OSU-T315,OSU-T-315,Apoptosis,inhibit,Autophagy,OSU T315,OSUT315

OSU-T315, 10 mM in DMSO

OSU-T315 ，S6840

2070015-22-2