BC-1382
- Product Name
- BC-1382
- CAS No.
- 1013753-99-5
- Chemical Name
- BC-1382
- Synonyms
- BC-1382;BC-1382, 10 mM in DMSO;(S)-N-(1-((2-Methoxybenzyl)amino)-1-oxopropan-2-yl)-1-(phenylsulfonyl)piperidine-4-carboxamide;1-(benzenesulfonyl)-N-[(2S)-1-[(2-methoxyphenyl)methylamino]-1-oxopropan-2-yl]piperidine-4-carboxamide;4-Piperidinecarboxamide, N-[(1S)-2-[[(2-methoxyphenyl)methyl]amino]-1-methyl-2-oxoethyl]-1-(phenylsulfonyl)-;interaction,Anti-inflammatory,ligase,Inhibitor,lung,Ubiquitin,E1 activating enzyme,Ubiquitin activating enzyme,inhibit,HECTD2,inflammation,E3 ligating enzyme,E1/E2/E3 Enzyme,BC1382,BC 1382,BC-1382,HECTD2/PIAS1,Ubiquitin ligase,Ubiquitin conjugating enzyme,E2 conjugating enzyme
- CBNumber
- CB43121924
- Molecular Formula
- C23H29N3O5S
- Formula Weight
- 459.56
- MOL File
- 1013753-99-5.mol
BC-1382 Property
- Melting point:
- 163 - 164°C
- storage temp.
- -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 43143
- Product name
- BC-1382
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $204
- Updated
- 2026/04/30
- Product number
- 43143
- Product name
- BC-1382
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $388
- Updated
- 2026/04/30
- Product number
- 43143
- Product name
- BC-1382
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $1018
- Updated
- 2026/04/30
- Product number
- 43143
- Product name
- BC-1382
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $1832
- Updated
- 2026/04/30
- Product number
- B129353
- Product name
- BC-1382
- Packaging
- 250mg
- Price
- $605
- Updated
- 2021/12/16
BC-1382 Chemical Properties,Usage,Production
Uses
BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction (IC50≈ 5 nM).Anti-inflammatory activity[1].
in vivo
BC-1382 (10 mg/kg; intraperitoneal injection) significantly decreases lavage protein concentrations, lavage cell counts, and cell infiltrates in both PA103-stimulated and LPS-stimulated mice. BC-1382 significantly decreases lavage cytokine levels in both models[1].
| Animal Model: | C57BL/6J mice were challenged intratracheally with PA103 (104 CFU per mouse) or LPS (3 mg/kg)[1] |
| Dosage: | 10 mg/kg |
| Administration: | Given through intraperitoneal injection |
| Result: | Significantly decreased lavage protein concentrations, lavage cell counts, and cell infiltrates in both PA103-stimulated and LPS-stimulated mice. Significantly decreased lavage cytokine levels in both models. |
References
[1] Tiffany A Coon, et al. The proinflammatory role of HECTD2 in innate immunity and experimental lung injury. Sci Transl Med. 2015 Jul 8;7(295):295ra109. DOI:10.1126/scitranslmed.aab3881
BC-1382 Preparation Products And Raw materials
Raw materials
Preparation Products
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