KJ Pyr 9
- Product Name
- KJ Pyr 9
- CAS No.
- 581073-80-5
- Chemical Name
- KJ Pyr 9
- Synonyms
- KJ Pyrq;KJ Pyr 9;4-[2-(2-Furyl)-6-(4-nitrophenyl)-4-pyridyl]benzamide;4-[2-(2-Furanyl)-6-(4-nitrophenyl)-4-pyridinyl]benzamide;4-(2-(Furan-2-yl)-6-(4-nitrophenyl)pyridin-4-yl)benzamide;Benzamide, 4-[2-(2-furanyl)-6-(4-nitrophenyl)-4-pyridinyl]-;c-Myc,KJ Pyr9,inhibit,Autophagy,Inhibitor,Myc,KJ Pyr 9,KJ Pyr-9
- CBNumber
- CB43122345
- Molecular Formula
- C22H15N3O4
- Formula Weight
- 385.37
- MOL File
- 581073-80-5.mol
KJ Pyr 9 Property
- Boiling point:
- 584.4±50.0 °C(Predicted)
- Density
- 1.320±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≤20mg/ml in DMSO;25mg/ml in dimethyl formamide
- form
- crystalline solid
- pka
- 15.34±0.50(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 19116
- Product name
- KJ Pyr 9
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 19116
- Product name
- KJ Pyr 9
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 19116
- Product name
- KJ Pyr 9
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $122
- Updated
- 2024/03/01
- Product number
- 19116
- Product name
- KJ Pyr 9
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $267
- Updated
- 2024/03/01
- Product number
- 5306
- Product name
- KJPyr9
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $520
- Updated
- 2021/12/16
KJ Pyr 9 Chemical Properties,Usage,Production
Uses
4-[2-(2-Furanyl)-6-(4-nitrophenyl)-4-pyridinyl]benzamide is a inhibits MYC-induced oncogenic transformation in cell culture and blocks the growth of a xenotransplant of MYC-amplified human cancer cells.
Biological Activity
mkj pyr 9 is a novel small molecule inhibitor of myc, with the kd value of 6.5 ± 1.0 nm. besides, kj pyr 9 also suppresses the formation of myc-max and oncogenic transformation induced by myc in cell culture [1].
in vitro
in chicken embryo fibroblasts, kj pyr 9 was found to have the ability to interfere with the oncogenic activity of myc, with the best aqueous solubility. besides, in human b-cell line p493-6, 20 μm kj pyr 9 could significantly inhibit cell proliferation, and kj pyr 9 could also inhibit the proliferation of nci-h460, mda-mb-231, and sum-159pt cell lines, with the ic50 values between 5-10 μm. furthermore, treatment of p493-6 cells with kj pyr 9 could significantly suppress the transcription ability of myc [1].
in vivo
kj pyr 9 was found to have no acute toxicity in mouse and rat at a dose of 10 mg/kg, with an impressive ability to cross the blood-brain barrier. besides, in a mda-mb-231 cells xenograft tumor nude mice model, intraperitoneal injection with 10 mg/kg kj pyr 9 for 31 days could significantly inhibit tumor growth, while having no effect on the body weight [1].
target
myc
storage
Store at +4°C
References
[1] hart j r, garner a l, yu j, et al. inhibitor of myc identified in a kröhnke pyridine library[j]. proceedings of the national academy of sciences, 2014, 111(34): 12556-12561.
KJ Pyr 9 Preparation Products And Raw materials
Raw materials
Preparation Products
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