MS049

Product Name: MS049
CAS No.: 1502816-23-0
Chemical Name: MS049
Synonyms: MS049;MS049 2HCl;MS049 diHCl;502816-23-0|MS049;MS049;MS-049;MS 049;MS049, 10 mM in DMSO;2-[4-(benzyloxy)piperidin-1-yl]ethyl}(methyl)amine;2-(4-(Benzyloxy)piperidin-1-yl)-N-methylethanamine;1-Piperidineethanamine, N-methyl-4-(phenylmethoxy)-;MS-049,arginine,Histone Methyltransferase,MS 049,HEK293,dimethylation,Inhibitor,toxic,H4R3me2a,MS049,inhibit,selective,epigenetic,cells,modifiers
CBNumber: CB43128918
Molecular Formula: C15H24N2O
Formula Weight: 248.36
MOL File: 1502816-23-0.mol

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MS049 Property

Boiling point:: 352.6±37.0 °C(Predicted)
Density: 1.03±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: ≥ 31 mg/mL (124.82 mM)
pka: 10.48±0.10(Predicted)
form: Solid
color: Light yellow to yellow
Water Solubility: H2O: 20mg/mL, clear
InChI: 1S/C15H24N2O.ClH/c1-16-9-12-17-10-7-15(8-11-17)18-13-14-5-3-2-4-6-14;/h2-6,15-16H,7-13H2,1H3;1H
InChIKey: FJZNVFFTIKWXMA-UHFFFAOYSA-N
SMILES: CNCCN(CC1)CCC1OCC2=CC=CC=C2.[H]Cl

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Safety

WGK Germany: WGK 3
Storage Class: 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications: Acute Tox. 3 Oral

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5861
Product name: MS049
Purity: >98.0%
Packaging: 5mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-5861
Product name: MS049
Purity: >98.0%
Packaging: 10mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-5861
Product name: MS049
Purity: >98.0%
Packaging: 25mg
Price: $220
Updated: 2021/12/16

ChemScene

Product number: CS-5861
Product name: MS049
Purity: >98.0%
Packaging: 50mg
Price: $400
Updated: 2021/12/16

ChemScene

Product number: CS-5861
Product name: MS049
Purity: >98.0%
Packaging: 100mg
Price: $750
Updated: 2021/12/16

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MS049 Chemical Properties,Usage,Production

Uses

MS049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC50s of 34 nM and 43 nM, respectively. MS049 reduces levels of Med12me2a and H3R2me2a in HEK293 cells. MS049 is not toxic and does not affect the growth of HEK293 cells[1].

Biological Activity

MS049 is a potent and selective inhibitor of protein arginine methyltransferases (PRMTs) PRMT 4 and PRMT6. MS049 is active in cells. For full characterization details, please visit the MS049 probe summary on the Structural Genomics Consortium (SGC) website.

MS049N is the negative control for the active probe, MS049. To request a sample of the negative control from the SGC, click here.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

IC 50

PRMT4: 34 nM (); PRMT6: 43 nM (); PRMT8: 1600 nM ()

References

[1] Shen Y et al. Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6. J Med Chem. 2016 Sep 15. DOI:10.1021/acs.jmedchem.6b01033

MS049 Preparation Products And Raw materials

Raw materials

Preparation Products

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MS049 Suppliers

China 61 United States 6 Global 67

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1502816-23-0, MS049Related Search:

FOOD RED NO 3 ALUMINUM LAKE GLPG0974

MS049

MS049 2HCl

2-[4-(benzyloxy)piperidin-1-yl]ethyl}(methyl)amine

MS049;MS-049;MS 049

1-Piperidineethanamine, N-methyl-4-(phenylmethoxy)-

2-(4-(Benzyloxy)piperidin-1-yl)-N-methylethanamine

MS049 diHCl

MS-049,arginine,Histone Methyltransferase,MS 049,HEK293,dimethylation,Inhibitor,toxic,H4R3me2a,MS049,inhibit,selective,epigenetic,cells,modifiers

MS049, 10 mM in DMSO

502816-23-0|MS049

1502816-23-0

502816-23-0