ChemicalBook > CAS DataBase List > PIK-III
PIK-III
- Product Name
- PIK-III
- CAS No.
- 1383716-40-2
- Chemical Name
- PIK-III
- Synonyms
- PIK-Ⅲ;PIK-III;Vps34-PIK-III;Vps34 inhibitor PIK-III;4'-(Cyclopropylmethyl)-N2-4-pyridinyl[4,5'-bipyrimidine]-2,2'-diamine;[4,5'-Bipyrimidine]-2,2'-diamine, 4'-(cyclopropylmethyl)-N2-4-pyridinyl-;4'-(Cyclopropylmethyl)-N2-(pyridin-4-yl)-[4,5'-bipyrimidine]-2,2'-diamine;4'-(Cyclopropylmethyl)-N2-(pyridin-4-yl)-[4,5'-bipyrimidine]-2,2'-diamine;PI3K,Autophagy,Vps34 PIK III,Vps-34-PIK-III,Inhibitor,Phosphoinositide 3-kinase,Vps34PIKIII,inhibit
- CBNumber
- CB43133178
- Molecular Formula
- C17H17N7
- Formula Weight
- 319.36
- MOL File
- 1383716-40-2.mol
More
Less
PIK-III Property
- Boiling point:
- 657.4±65.0 °C(Predicted)
- Density
- 1.380±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥31.9 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
- form
- solid
- pka
- 6.19±0.26(Predicted)
More
Less
N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 17002
- Product name
- PIK-III
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $74
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17002
- Product name
- PIK-III
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $220
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17002
- Product name
- PIK-III
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $365
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17002
- Product name
- PIK-III
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $699
- Updated
- 2024/03/01
Activate Scientific
- Product number
- AS118254
- Product name
- PIK-III
- Purity
- 98+%
- Packaging
- 25mg
- Price
- $773
- Updated
- 2021/12/16
More
Less
PIK-III Chemical Properties,Usage,Production
Biological Activity
pik-iii is a vps34 inhibitor and is able to inhibit autophagy.vps34 kinase has been found to be responsible for synthesis and deposition of phosphatidylinositol-3-phosphate at autophagosome formation sites, resulting in the recruitment of ptdins(3)p-binding proteins.
in vitro
in previous study, pik-iii was identified as a selective inhibitor of vps34 binding in a hydrophobic pocket. in addition, pik-iii could acutely inhibit the autophagy and lipidation of lc3, which led to the stabilization of autophagy substrates. moreover, substrates such as ncoa4 were identified by conducting ubiquitin-affinity proteomic assay on pik-iii-treated cells, which accumulated in cells with atg7 deficience and co-localized with autolysosomes. ncoa4 could bind ferritin heavy chain-1 directly to target the iron-binding ferritin complex following starvation or iron depletion [1].
in vivo
animal study showed that pik-iii-treated ncoa4-/- mice had a profound accumulation of iron in splenic macrophages that were important for iron reutilization from engulfed red blood cells. in summary, such in vivo results provided a novel mechanism for selective autophagy of ferritin and revealed a previously untouched role for autophagy and ncoa4 in the control of in-vivo iron homeostasis [1].
IC 50
18 nm for vps34
References
[1] dowdle we et al. selective vps34 inhibitor blocks autophagy and uncovers a role for ncoa4 in ferritin degradation and iron homeostasis in vivo. nat cell biol. 2014 nov;16(11):1069-79.
PIK-III Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
PIK-III Suppliers
- Tel
- 021-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6011
- Advantage
- 61
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 18089
- Advantage
- 64
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
- Country
- China
- ProdList
- 4664
- Advantage
- 58
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2989
- Advantage
- 60
- Tel
- QQ:65489617 15618227136
- Fax
- 21-5161 9052
- info@SuperLan-chem.com
- Country
- China
- ProdList
- 9756
- Advantage
- 58
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
- Country
- China
- ProdList
- 29796
- Advantage
- 68
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131981
- Advantage
- 58
- Tel
- 17317130613
- Fax
- QQ3358272972
- 3358272972@qq.com
- Country
- China
- ProdList
- 3244
- Advantage
- 58
- Tel
- 021-50822001
- marketing@medicilon.com.cn
- Country
- China
- ProdList
- 1152
- Advantage
- 58
- Tel
- 15911056312
- liming@bio-fount.com
- Country
- China
- ProdList
- 9730
- Advantage
- 58
- Tel
- 020-31155029 18902330969
- Fax
- 020-31155029
- sales@tomums.cn
- Country
- China
- ProdList
- 4698
- Advantage
- 58
- Tel
- 0576-88813233 13396860566
- sales@pharm-intermediates.com
- Country
- China
- ProdList
- 2013
- Advantage
- 58
- Tel
- +8618530059196
- sale04@alfachem.cn
- Country
- China
- ProdList
- 12731
- Advantage
- 58
- Tel
- 86-571-88216897,88216896 13588875226
- Fax
- 86-571-88216895
- sales@hzclap.com
- Country
- CHINA
- ProdList
- 6313
- Advantage
- 58
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com
- Country
- China
- ProdList
- 9414
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11289
- Advantage
- 58
- Tel
- 021-38015121 15000105423
- chenjw@absin.cn
- Country
- China
- ProdList
- 24734
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58
- Tel
- 16621358918
- Fax
- QQ:402135374
- botuopharma888@163.com
- Country
- China
- ProdList
- 9215
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44843
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8141
- Advantage
- 58
- Tel
- 13303867194
- 3001317055@qq.com
- Country
- China
- ProdList
- 9627
- Advantage
- 58
- Tel
- 400-1647117 15221909166
- product02@bidepharm.com
- Country
- China
- ProdList
- 63720
- Advantage
- 58
- Tel
- 0371-65741762
- Fax
- QQ：2860768577
- sales@hasunny.com
- Country
- China
- ProdList
- 2380
- Advantage
- 58
- Tel
- 13549236410
- sales@invivochem.cn
- Country
- China
- ProdList
- 6713
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24018
- Advantage
- 58
- Tel
- 0371-55013243 15324716602
- 2853979810@qq.com
- Country
- China
- ProdList
- 9943
- Advantage
- 58
- Tel
- 021-50706066 15221275939
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 29803
- Advantage
- 58
- Tel
- 0512-65118909 15162312715
- sales@szzxbio.com
- Country
- China
- ProdList
- 2985
- Advantage
- 58
- Tel
- 021-57520305 15001810326
- guojianing@jskchem.com
- Country
- China
- ProdList
- 49242
- Advantage
- 58
- Tel
- 021-65675885 18964387627
- customer_service@efebio.com
- Country
- China
- ProdList
- 8740
- Advantage
- 58
- Tel
- +86-18521732826
- market@aladdin-e.com
- Country
- China
- ProdList
- 48467
- Advantage
- 58
- Tel
- +undefined-21-51877795
- Fax
- +86 21 5161 9052/ 5187 7796
- ivan@atkchemical.com
- Country
- China
- ProdList
- 32686
- Advantage
- 60
- Tel
- --
- Fax
- --
- shxiyuanbio@163.com
- Country
- CHINA
- ProdList
- 6921
- Advantage
- 58
- Tel
- --
- Fax
- --
- lyn@biopike.com.cn
- Country
- CHINA
- ProdList
- 6629
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@wheybio.com
- Country
- CHINA
- ProdList
- 4398
- Advantage
- 58
- Tel
- --
- Fax
- --
- WHIGA22@126.COM
- Country
- CHINA
- ProdList
- 6748
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@shrbio.com
- Country
- CHINA
- ProdList
- 6873
- Advantage
- 58
- Tel
- --
- Fax
- --
- john.st@163.com
- Country
- CHINA
- ProdList
- 1472
- Advantage
- 58
- Tel
- --
- Fax
- --
- jingkehuaxue@163.com
- Country
- CHINA
- ProdList
- 6974
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1914109725@qq.com
- Country
- CHINA
- ProdList
- 6530
- Advantage
- 58
- Tel
- --
- Fax
- --
- chenxue_gz@163.com
- Country
- CHINA
- ProdList
- 6618
- Advantage
- 58
- Tel
- --
- Fax
- --
- 15800446246@163.com
- Country
- CHINA
- ProdList
- 5417
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1861586486@qq.com
- Country
- CHINA
- ProdList
- 6652
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6846
- Advantage
- 58