ALS-8176

Product Name: ALS-8176
CAS No.: 1445385-02-3
Chemical Name: ALS-8176
Synonyms: ALS-8176;ALS-008176;Lumicitabine;Lumicitabine (ALS-8176);ALS-8176 (Lumicitabine;LUMICITABINE;ALS8176;ALS 8176;4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine;Cytidine, 4'-C-(chloromethyl)-2'-deoxy-2'-fluoro-, 3',5'-bis(2-methylpropanoate);4-Amino-1-{5-chloro-2,5-dideoxy-2-fluoro-3-O-isobutyryl-4-[(isobutyryloxy)methyl]-a-L-lyxofuranosyl}-2(1H)-pyrimidinone
CBNumber: CB43133345
Molecular Formula: C18H25ClFN3O6
Formula Weight: 433.86
MOL File: 1445385-02-3.mol

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ALS-8176 Property

Boiling point:: 533.5±60.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 50 mg/mL (115.24 mM)
form: Solid
pka: 4.26±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5699
Product name: Lumicitabine
Purity: 99.78%
Packaging: 1mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-5699
Product name: Lumicitabine
Purity: 99.78%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-5699
Product name: Lumicitabine
Purity: 99.78%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611588
Product name: ALS-8176
Packaging: 100mg
Price: $1208.7
Updated: 2021/12/16

ChemScene

Product number: CS-5699
Product name: Lumicitabine
Purity: 99.78%
Packaging: 50mg
Price: $1800
Updated: 2021/12/16

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ALS-8176 Chemical Properties,Usage,Production

Uses

Lumicitabine (ALS-008176) is an inhibitor of the respiratory syncytial virus (RSV) polymerase.

in vivo

Lumicitabine demonstrates excellent anti-RSV efficacy and safety in a phase 2 clinical RSV challenge study. It exhibits good oral bioavailability and a high level of 2c-TP in vivo. Lumicitabine has excellent stability profiles in formulations (>24 h storage stability in 0.5% methylcellulose aqueous formulation at rt) and simulats gastric and intestinal fluids (half-life >2 h). Its solubility is adequate to support oral administration in solutions with relatively low percentage of organic solvent and in aqueous suspensions. High levels of NMP and NTP are obtained following oral administration of Lumicitabine to monkeys^[2]. In an adult human challenge study, Lumicitabine has shown efficacy against RSV infection^[1].

References

[1] DeVincenzo JP, et al. Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study. N Engl J Med. 2015 Nov 19;373(21):2048-58. DOI:10.1056/NEJMoa1413275
[2] Wang G, et al. Discovery of 4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine (ALS-8176), a first-in-class RSV polymerase inhibitor for treatment of human respiratory syncytial virus infection. J Med Chem. 2015 Feb 26;58(4):1862-78. DOI:10.1021/jm5017279

ALS-8176 Preparation Products And Raw materials

Raw materials

Preparation Products

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ALS-8176 Suppliers

China 33 United States 5 Global 38

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
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Suzhou PengXu PharmaTech Co., Ltd.

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Email: sales@cqpharm.com
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ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
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Amadis Chemical Company Limited

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Email: sales@amadischem.com
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Dezhou LonWel Pharmaceutical Technology Co., Ltd.

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Shanghai Biopharmaleader Co., Ltd.

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Musechem

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Shanghai Moss Medicine Technology Co., Ltd.

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Fan De(Beijing) Biotechnology Co., Ltd.

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NewCan Biotech Limited

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1445385-02-3, ALS-8176Related Search:

ALS-8176

4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine

ALS-008176

Lumicitabine

4-Amino-1-{5-chloro-2,5-dideoxy-2-fluoro-3-O-isobutyryl-4-[(isobutyryloxy)methyl]-a-L-lyxofuranosyl}-2(1H)-pyrimidinone

LUMICITABINE;ALS8176;ALS 8176

ALS-8176 (Lumicitabine

Lumicitabine (ALS-8176)

Cytidine, 4'-C-(chloromethyl)-2'-deoxy-2'-fluoro-, 3',5'-bis(2-methylpropanoate)

1445385-02-3