ChemicalBook > CAS DataBase List > 8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one

8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one

Product Name
8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one
CAS No.
1607837-31-9
Chemical Name
8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one
Synonyms
CCT-251921;LM-3860,CCT251921;CCT-251921;CCT 251921;CCT-251921, 10 mM in DMSO;CCT-251921,Cyclin dependent kinase,Inhibitor,CDK,CCT251921,CCT 251921,inhibit;8-[2-amino-3-chloro-5-(1-methylindazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one;8-[2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)-4-pyridinyl]-2,8-Diazaspiro[4.5]decan-1-one;8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one;2,8-Diazaspiro[4.5]decan-1-one, 8-[2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)-4-pyridinyl]-
CBNumber
CB43133466
Molecular Formula
C21H23ClN6O
Formula Weight
410.9
MOL File
1607837-31-9.mol
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8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one Property

Boiling point:
696.4±55.0 °C(Predicted)
Density 
1.51±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 28 mg/mL (68.14 mM)
pka
15.81±0.20(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-5521
Product name
CCT-251921
Purity
99.77%
Packaging
1mg
Price
$108
Updated
2021/12/16
ChemScene
Product number
CS-5521
Product name
CCT-251921
Purity
99.77%
Packaging
10mg
Price
$420
Updated
2021/12/16
ChemScene
Product number
CS-5521
Product name
CCT-251921
Purity
99.77%
Packaging
25mg
Price
$840
Updated
2021/12/16
ChemScene
Product number
CS-5521
Product name
CCT-251921
Purity
99.77%
Packaging
50mg
Price
$1140
Updated
2021/12/16
Crysdot
Product number
CD00008621
Product name
CCT251921
Purity
97%
Packaging
50mg
Price
$1496
Updated
2021/12/16
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8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one Chemical Properties,Usage,Production

Description

CCT251921 is a potent, selective, and orally bioavailable small-molecule modulators of the mediator complex-associated kinases CDK8 and CDK19. (IC50 data: CDK8:=2.3 nM; CDK19 = 2.6 nM). CCT251921 showed the optimal compromise of in vitro biochemical, pharmacokinetic, and physicochemical properties and is suitable for progression to animal models of cancer. The Mediator complex-associated cyclin-dependent kinase CDK8 has been implicated in human disease, particularly in colorectal cancer where it has been reported as a putative oncogene.

8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one Preparation Products And Raw materials

Raw materials

Preparation Products

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8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one Suppliers

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1607837-31-9, 8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-oneRelated Search:


  • 8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one
  • CCT-251921
  • LM-3860,CCT251921
  • 8-[2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)-4-pyridinyl]-2,8-Diazaspiro[4.5]decan-1-one
  • CCT-251921;CCT 251921
  • 8-[2-amino-3-chloro-5-(1-methylindazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one
  • 2,8-Diazaspiro[4.5]decan-1-one, 8-[2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)-4-pyridinyl]-
  • CCT-251921,Cyclin dependent kinase,Inhibitor,CDK,CCT251921,CCT 251921,inhibit
  • CCT-251921, 10 mM in DMSO
  • 1607837-31-9