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SirReal2

Product Name
SirReal2
CAS No.
709002-46-0
Chemical Name
SirReal2
Synonyms
SirReal2;SirReal2 ，S7845;SirReal2 >=98% (HPLC);SirReal2, 10 mM in DMSO;Sirtuin,Inhibitor,inhibit,SirReal2,SirReal 2,SirReal-2;2-[(4,6-Dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]acetamide;2-((4,6-Dimethylpyrimidin-2-yl)thio)-N-(5-(naphthalen-1-ylmethyl)thiazol-2-yl)acetamide;Acetamide,2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]-;2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide
CBNumber
CB43133754
Molecular Formula
C22H20N4OS2
Formula Weight
420.55
MOL File
709002-46-0.mol
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SirReal2 Property

storage temp. 
Store at -20°C
solubility 
DMSO: 3 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml
form 
A crystalline solid
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1514
Product name
SirReal2
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$117
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1514
Product name
SirReal2
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$362
Updated
2025/07/31
Cayman Chemical
Product number
18116
Product name
SirReal2
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
18116
Product name
SirReal2
Purity
≥98%
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
18116
Product name
SirReal2
Purity
≥98%
Packaging
10mg
Price
$178
Updated
2024/03/01
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SirReal2 Chemical Properties,Usage,Production

Description

Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). SIRT2 deacetylates histone H4 and α-tubulin and functions as a regulator of cell cycle progression, a determinant of myelination, a modulator of autophagy, and a suppressor of brain inflammation. SirReal2 is an aminothiazole that acts as a SIRT-rearranging ligand to selectively inhibit SIRT2 (IC50 = 140 nM). SirReal2 is >1,000-fold more potent at inhibiting the activity of SIRT2 than that of SIRT1 or SIRT3-6. This compound has been shown to be active in HeLa cells by significantly increasing α-tubulin acetylation.

Uses

SirReal2 is an aminothiazole that is a potent and selective Sirt2 inhibitor.

in vivo

SirReal2 (4 mg/kg, i.p., every 3 days for 28 days) combined with VS-5584 (4mg/kg, i.p., every 3 days for 28 days) leads to an extension of the survival time of mice and exhibits significant anti-tumor effects[3].
SirReal2 (50 mg/kg, i.p., every 3 days for 19 days) inhibits the expression of SIRT2, resumes NK cell tumor infltration and suppresses melanoma progression in WT mice[4].

Animal Model:mouse tumor xenograft model[3]
Dosage:4 mg/kg
Administration:i.p., every 3 days for 28 days
Result:Restrained the growth of subcutaneous xenografts combined with VS-5584 in vivo.

IC 50

SIRT2: 140 nM (IC50)

storage

Store at -20°C

References

[1] TOBIAS RUMPF. Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.[J]. Nature Communications, 2015: 6263. DOI: 10.1038/ncomms7263

SirReal2 Preparation Products And Raw materials

Raw materials

Preparation Products

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SirReal2 Suppliers

China 75 United Kingdom 1 United States 8 Global 84
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
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China
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16075
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AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
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60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
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Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
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9125
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Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3277
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58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
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58
Guangzhou Tomums Life Science Co., Ltd.
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020-31155029 18902330969
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020-31155029
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sales@tomums.cn
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China
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4696
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InvivoChem
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+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
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58
Wuxi Donghe Pharmaceutical Technology Co., Ltd.
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63313187 15358055255
Fax
QQ：63313187
Email
63313187@qq.com
Country
China
ProdList
1984
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709002-46-0, SirReal2Related Search:

Acetamide 2-Amino-4,6-dimethylpyrimidine

  • SirReal2
  • Acetamide,2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]-
  • 2-[(4,6-Dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]acetamide
  • 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide
  • SirReal2 >=98% (HPLC)
  • Sirtuin,Inhibitor,inhibit,SirReal2,SirReal 2,SirReal-2
  • 2-((4,6-Dimethylpyrimidin-2-yl)thio)-N-(5-(naphthalen-1-ylmethyl)thiazol-2-yl)acetamide
  • SirReal2, 10 mM in DMSO
  • SirReal2 ，S7845
  • 709002-46-0