SirReal2
- Product Name
- SirReal2
- CAS No.
- 709002-46-0
- Chemical Name
- SirReal2
- Synonyms
- SirReal2;SirReal2 >=98% (HPLC);Sirtuin,Inhibitor,inhibit,SirReal2,SirReal 2,SirReal-2;2-[(4,6-Dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]acetamide;2-((4,6-Dimethylpyrimidin-2-yl)thio)-N-(5-(naphthalen-1-ylmethyl)thiazol-2-yl)acetamide;Acetamide,2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]-;2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide
- CBNumber
- CB43133754
- Molecular Formula
- C22H20N4OS2
- Formula Weight
- 420.55
- MOL File
- 709002-46-0.mol
SirReal2 Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: 3 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml
- form
- A crystalline solid
- color
- Off-white to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 18116
- Product name
- SirReal2
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 18116
- Product name
- SirReal2
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 18116
- Product name
- SirReal2
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $178
- Updated
- 2024/03/01
- Product number
- 18116
- Product name
- SirReal2
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $793
- Updated
- 2024/03/01
- Product number
- 5457
- Product name
- SirReal2
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $664
- Updated
- 2021/12/16
SirReal2 Chemical Properties,Usage,Production
Description
Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). SIRT2 deacetylates histone H4 and α-tubulin and functions as a regulator of cell cycle progression, a determinant of myelination, a modulator of autophagy, and a suppressor of brain inflammation. SirReal2 is an aminothiazole that acts as a SIRT-rearranging ligand to selectively inhibit SIRT2 (IC50 = 140 nM). SirReal2 is >1,000-fold more potent at inhibiting the activity of SIRT2 than that of SIRT1 or SIRT3-6. This compound has been shown to be active in HeLa cells by significantly increasing α-tubulin acetylation.
Uses
SirReal2 is an aminothiazole that is a potent and selective Sirt2 inhibitor.
storage
Store at -20°C
SirReal2 Preparation Products And Raw materials
Raw materials
Preparation Products
SirReal2 Suppliers
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