N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide

ChemicalBook > CAS DataBase List > N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide

N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide

Product Name: N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide
CAS No.: 1210608-43-7
Chemical Name: N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide
Synonyms: PIM447;EOS-60671;PIM447 (LGH447);PIM447 (LGH447) Free Base;N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide;2-Pyridinecarboxamide, N-[4-[(1R,3S,5S)-3-amino-5-methylcyclohexyl]-3-pyridinyl]-6-(2,6-difluorophenyl)-5-fluoro-
CBNumber: CB43143070
Molecular Formula: C24H23F3N4O
Formula Weight: 440.46
MOL File: 1210608-43-7.mol

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N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide Property

Boiling point:: 493.7±45.0 °C(Predicted)
Density: 1.290±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:88.0(Max Conc. mg/mL);199.79(Max Conc. mM)
Ethanol:88.0(Max Conc. mg/mL);199.79(Max Conc. mM)
form: Solid
pka: 1.35±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: P446750
Product name: PIM447
Packaging: 0.25mg
Price: $185
Updated: 2021/12/16

TRC

Product number: P446750
Product name: PIM447
Packaging: 2.5mg
Price: $1025
Updated: 2021/12/16

CSNpharm

Product number: CSN19123
Product name: PIM-447
Packaging: 10mg
Price: $480
Updated: 2021/12/16

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N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide Chemical Properties,Usage,Production

Uses

PIM kinases promote growth and survival of tumor cells and are expressed in a wide variety of human cancers. These kinases are potential therapeutic targets. PIM447 is a PIM kinase inhibitor.

N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide Preparation Products And Raw materials

Raw materials

Preparation Products

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1210608-43-7, N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamideRelated Search:

N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide

PIM447 (LGH447)

PIM447

PIM447 (LGH447) Free Base

EOS-60671

2-Pyridinecarboxamide, N-[4-[(1R,3S,5S)-3-amino-5-methylcyclohexyl]-3-pyridinyl]-6-(2,6-difluorophenyl)-5-fluoro-

1210608-43-7