ChemicalBook > CAS DataBase List > (3E,5E)-3,5-Bis(3,4-Dichlorobenzylidene)Piperidin-4-One

(3E,5E)-3,5-Bis(3,4-Dichlorobenzylidene)Piperidin-4-One

Product Name: (3E,5E)-3,5-Bis(3,4-Dichlorobenzylidene)Piperidin-4-One
CAS No.: 145888-79-5
Chemical Name: (3E,5E)-3,5-Bis(3,4-Dichlorobenzylidene)Piperidin-4-One
Synonyms: RAMB4;ptpib-in-9;PTP1B-IN-9?;PTP1B-IN-9 (RAMB4);RAMB4( PTP1B-IN-9);3,5-Bis(3,4-dichlorobenzylidene)piperidin-4-one;3,5-bis[(3,4-dichlorophenyl)methylidene]piperidin-4-one;(3E,5E)-3,5-Bis(3,4-Dichlorobenzylidene)Piperidin-4-One;4-Piperidinone, 3,5-bis[(3,4-dichlorophenyl)methylene]-;(3E,5E)-3,5-Bis(3,4-Dichlorobenzylidene)Piperidin-4-One(WXC02309)
CBNumber: CB43143227
Molecular Formula: C19H13Cl4NO
Formula Weight: 413.12
MOL File: 145888-79-5.mol

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(3E,5E)-3,5-Bis(3,4-Dichlorobenzylidene)Piperidin-4-One Property

Boiling point:: 607.5±55.0 °C(Predicted)
Density: 1.463±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility: DMSO: 5 mg/mL (12.10 mM)
form: A solid
pka: 6.43±0.20(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0047244
Product name: PTP1B-IN-9
Purity: 98.43%
Packaging: 5g
Price: $1835
Updated: 2021/12/16

Ambeed

Product number: A324091
Product name: 3,5-Bis(3,4-dichlorobenzylidene)piperidin-4-one
Purity: 97%
Packaging: 5mg
Price: $40
Updated: 2021/12/16

Ambeed

Product number: A324091
Product name: 3,5-Bis(3,4-dichlorobenzylidene)piperidin-4-one
Purity: 97%
Packaging: 10mg
Price: $64
Updated: 2021/12/16

CSNpharm

Product number: CSN25332
Product name: 3,5-Bis(3,4-dichlorobenzylidene)piperidin-4-one
Packaging: 10mg
Price: $80
Updated: 2021/12/16

Ambeed

Product number: A324091
Product name: 3,5-Bis(3,4-dichlorobenzylidene)piperidin-4-one
Purity: 97%
Packaging: 25mg
Price: $91
Updated: 2021/12/16

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(3E,5E)-3,5-Bis(3,4-Dichlorobenzylidene)Piperidin-4-One Chemical Properties,Usage,Production

Uses

RAMB4 is a ubiquitin-proteasome system (UPS)-stressor. RAMB4 inhibits ubiquitin-mediated protein degradation upstream of the 20S proteasomal catalytic activites. RAMB4 triggers a ubiquitin-proteasome-system (UPS)-stress response without affecting 20S proteasome catalytic activities. Anticancer activity[1].

References

[1] Anchoori RK, et al. Stressing?the?ubiquitin-proteasome?system?without?20S?proteolytic?inhibition?selectively?kills?cervical?cancer?cells.PLoS One.?2011;6(8):e23888. DOI:10.1371/journal.pone.0023888

(3E,5E)-3,5-Bis(3,4-Dichlorobenzylidene)Piperidin-4-One Preparation Products And Raw materials

Raw materials

Preparation Products

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145888-79-5, (3E,5E)-3,5-Bis(3,4-Dichlorobenzylidene)Piperidin-4-OneRelated Search:

PTP1B-IN-9?

(3E,5E)-3,5-Bis(3,4-Dichlorobenzylidene)Piperidin-4-One

(3E,5E)-3,5-Bis(3,4-Dichlorobenzylidene)Piperidin-4-One(WXC02309)

4-Piperidinone, 3,5-bis[(3,4-dichlorophenyl)methylene]-

RAMB4

3,5-Bis(3,4-dichlorobenzylidene)piperidin-4-one

RAMB4( PTP1B-IN-9)

inhibit,cancer,Proteasome,RAMB4,stress,degradation,Ubiquitin,RAMB 4,Inhibitor,response,cells,HeLa,RAMB-4,cervical

ptpib-in-9

PTP1B-IN-9 (RAMB4)

3,5-bis[(3,4-dichlorophenyl)methylidene]piperidin-4-one

145888-79-5

C19H13Cl4NO