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tert-butyl (R)-3-(hydroxymethyl)hexanoate

Product Name
tert-butyl (R)-3-(hydroxymethyl)hexanoate
CAS No.
1928755-17-2
Chemical Name
tert-butyl (R)-3-(hydroxymethyl)hexanoate
Synonyms
Buvacitan impurity 2;Brivaracetam Impurity 6;tert-butyl (R)-3-(hydroxymethyl)hexanoate;(R)-tert-Butyl 3-(hydroxymethyl)hexanoate;(R)-tert-Butyl 3-(hydroxymethyl)hexanoate (Brivaracetam Impurity);Hexanoic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester, (3R)-
CBNumber
CB43143999
Molecular Formula
C11H22O3
Formula Weight
202.29
MOL File
1928755-17-2.mol
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tert-butyl (R)-3-(hydroxymethyl)hexanoate Property

Boiling point:
278.5±23.0 °C(Predicted)
Density 
0.956±0.06 g/cm3(Predicted)
pka
14.78±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Crysdot
Product number
CD13019350
Product name
(R)-tert-Butyl3-(hydroxymethyl)hexanoate
Purity
97%
Packaging
1g
Price
$591
Updated
2021/12/16
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tert-butyl (R)-3-(hydroxymethyl)hexanoate Chemical Properties,Usage,Production

Uses

Tert-butyl (R)-3-(hydroxymethyl)hexanoate is employed in the biocatalytic route to the novel antiepileptic drug brivaracetam.

Synthesis

Sodium borohydride was slowly added to pre-cooled tetrahydrofuran at -5-0°C and stirred for 5 min. BF3-etherate (25.6 g) was slowly added to the reaction mixture at -5-0°C and stirred for 15 min at the same temperature. (R)-2-(2-(tert-butoxy)-2-oxoethyl)pentanoic acid (23 g) was added to the reaction mixture and stirred for 3 h. The reaction mixture was slowly quenched with water and raised the temperature of the reaction mixture to 25-30°C. Separated both the aqueous and organic layers and the aqueous layer was extracted with ethyl acetate. Combined the organic layers and washed with aqueous sodium chloride solution. Distilled off solvent completely from the organic layer to get tert-butyl (R)-3-(hydroxymethyl)hexanoate.Yield: 16.2 g.

tert-butyl (R)-3-(hydroxymethyl)hexanoate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-butyl (R)-3-(hydroxymethyl)hexanoate Suppliers

China 30 India 2 United States 2 Global 34
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1928755-17-2, tert-butyl (R)-3-(hydroxymethyl)hexanoateRelated Search:

Dihydro-4-propyl-2(3H)-furanone Brivaracetam (Racemate) Brivaracetam (R)-2-(2-(tert-butoxy)-2-oxoethyl)pentanoic acid (4S)-BrivaracetaM Brivaracetam (alfaR, 4R)-Isomer Brivaracetam (alfaR, 4S)-Isomer (Z)-2-propylhept-2-enal (R)-4-Propyldihydrofuran-2(3H)-one Brivaracetam Impurity 21 Brivaracetam Impurity 9 (R)-N-((S)-1-amino-1-oxobutan-2-yl)-3-(bromomethyl)hexanamide Brivaracetam Impurity 5 (R)-Ethyl 3-(bromomethyl)hexanoate Brivaracetam Impurity 10 Brivaracetam Impurity B Brivaracetam Impurity 11 Brivaracetam Impurity 14

  • Brivaracetam Impurity 6
  • (R)-tert-Butyl 3-(hydroxymethyl)hexanoate
  • Hexanoic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester, (3R)-
  • (R)-tert-Butyl 3-(hydroxymethyl)hexanoate (Brivaracetam Impurity)
  • Buvacitan impurity 2
  • tert-butyl (R)-3-(hydroxymethyl)hexanoate
  • 1928755-17-2