2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione
- Product Name
- 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione
- CAS No.
- 835616-60-9
- Chemical Name
- 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione
- Synonyms
- 4-Fluoro-thalidomide;2-(2,6-Dioxo-3-piperidinyl)-4-fluoro-1,3-isoindolinedione;2-(2,6-Dioxopiperidin-3-yl)-4-fluoro-2,3-dihydro-1H-isoindole-1,3-dione;135582;TC-E3 5032;E3 ligase Ligand 4;Thalidomide 4-fluoride;E3 ligase Ligand 4(TC-E3 5032);Pomalidomide Related Compound 7;2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione
- CBNumber
- CB43145029
- Molecular Formula
- C13H9FN2O4
- Formula Weight
- 276.22
- MOL File
- 835616-60-9.mol
2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione Property
- Melting point:
- 254-256°C
- Boiling point:
- 520.9±45.0 °C(Predicted)
- Density
- 1.570±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Dichloromethane (Slightly, Heated), DMSO (Slightly)
- pka
- 10.63±0.40(Predicted)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1S/C13H9FN2O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5H2,(H,15,17,18)
- InChIKey
- CRAUTELYXAAAPW-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C(F)=CC=C2)C(=O)N1C1CCC(=O)NC1=O
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P281Use personal protective equipment as required.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313IF exposed or concerned: Get medical advice/attention.
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 26147
- Product name
- TC-E3 5032
- Packaging
- 50mg
- Price
- $106
- Updated
- 2024/03/01
- Product number
- 26147
- Product name
- TC-E3 5032
- Packaging
- 500mg
- Price
- $261
- Updated
- 2024/03/01
- Product number
- 26147
- Product name
- TC-E3 5032
- Packaging
- 100mg
- Price
- $137
- Updated
- 2024/03/01
- Product number
- 26147
- Product name
- TC-E3 5032
- Packaging
- 250mg
- Price
- $233
- Updated
- 2024/03/01
- Product number
- 6628
- Product name
- TCE35032
- Purity
- ≥98%(HPLC)
- Packaging
- 100
- Price
- $409
- Updated
- 2021/12/16
2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione Chemical Properties,Usage,Production
Description
4-Fluoro-thalidomide is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. It can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966).
Uses
2-(2,6-Dioxo-3-piperidinyl)-4-fluoro-1H-isoindole-1,3(2H)-dione is an intermediate in the synthesis of N-[2-Aminoethyl] Pomalidomide TFA Salt (A6095150. N-[2-Aminoethyl] Pomalidomide TFA is a thalidomide derivative, a potent inhibitor of TNF-α production. It is an anti-inflammatory and anti-tumor agent used in the treatment of multiple myeloma.
Synthesis
A mixture of 4-fluoroisobenzofuran-l,3-dione (498.33 mg, 3.00 mmol), 3- aminopiperidine-2,6-dione hydrogen chloride (493.77 mg, 3.00 mmol) and NaOAc (246.09 mg, 3.00 mmol) in HOAc (10 mL) was stirred at 135 °C overnight, cooled and concentrated in vacuo. The residue was suspended in H2O (100 mL) and stirred at room temperature for 4 hours. The solid was collected via filtration and dried in vacuo to afford 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione as a white solid.
storage
Store at +4°C
2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione Preparation Products And Raw materials
Raw materials
Preparation Products
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- Product
- 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione 835616-60-9
- Price
- US $400.00/g
- Min. Order
- 10g
- Purity
- 98
- Supply Ability
- 5000
- Release date
- 2022-10-29
- Product
- 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione 835616-60-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-23
- Product
- 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione 835616-60-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10