NMS-P118

Product Name: NMS-P118
CAS No.: 1262417-51-5
Chemical Name: NMS-P118
Synonyms: CS-2354;NMS-P118;NMS-P118 ，S8363;NMS-P118, 10 mM in DMSO;NMS-P118; NMS-P 118; NMS P118;2-(1-(4,4-difluorocyclohexyl)piperidin-4-yl)-6-fluoro-3-oxoisoindoline-4-carboxamide;NMS-P118,inhibit,NMS P118,PARP,NMSP118,Inhibitor,poly ADP ribose polymerase,NMS-P-118;2-[1-(4,4-Difluorocyclohexyl)-4-piperidinyl]-6-fluoro-2,3-dihydro-3-oxo-1H-isoindole-4-carboxamide;2-[1-(4,4-difluorocyclohexyl)-piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide;1H-Isoindole-4-carboxamide, 2-[1-(4,4-difluorocyclohexyl)-4-piperidinyl]-6-fluoro-2,3-dihydro-3-oxo-
CBNumber: CB43147780
Molecular Formula: C20H24F3N3O2
Formula Weight: 395.42
MOL File: 1262417-51-5.mol

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NMS-P118 Property

storage temp.: Store at -20°C
solubility: DMF: 5 mg/ml; DMSO: 2 mg/ml; Ethanol: slightly soluble
form: A crystalline solid
color: White to off-white
InChI: InChI=1S/C20H24F3N3O2/c21-13-9-12-11-26(19(28)17(12)16(10-13)18(24)27)15-3-7-25(8-4-15)14-1-5-20(22,23)6-2-14/h9-10,14-15H,1-8,11H2,(H2,24,27)
InChIKey: ARYVAQSYRLZVQD-UHFFFAOYSA-N
SMILES: C1C2=C(C(C(N)=O)=CC(F)=C2)C(=O)N1C1CCN(C2CCC(F)(F)CC2)CC1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21340
Product name: NMS-P118
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 21340
Product name: NMS-P118
Purity: ≥98%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 21340
Product name: NMS-P118
Purity: ≥98%
Packaging: 10mg
Price: $283
Updated: 2024/03/01

Cayman Chemical

Product number: 21340
Product name: NMS-P118
Purity: ≥98%
Packaging: 25mg
Price: $618
Updated: 2024/03/01

TRC

Product number: D447770
Product name: 2-[1-(4,4-Difluorocyclohexyl)-4-piperidinyl]-6-fluoro-2,3-dihydro-3-oxo-1H-isoindole-4-carboxamide
Packaging: 5mg
Price: $450
Updated: 2021/12/16

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NMS-P118 Chemical Properties,Usage,Production

Uses

2-[1-(4,4-Difluorocyclohexyl)-4-piperidinyl]-6-fluoro-2,3-dihydro-3-oxo-1H-isoindole-4-carboxamide is a nuclear protein poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor. PARP-1 is involved with the signaling and repair of DNA and a target in oncology.

in vivo

NMS-P118 is a potent (K_D=0.009 μM) PARP-1 inhibitor, showing 150-fold selectivity over PARP-2 (K_D=1.39 μM). NMS-P118 possesses excellent pharmacokinetic profile and nearly complete oral bioavailability both in mice and rats. It proved to be highly efficacious in vivo both as single agent in MDA-MB-436 human breast cancer tumors and in combination with temozolomide in CAPAN-1 human pancreatic tumors growing as xenografts in the mouse. The compound is well tolerated at highly efficacious doses and is endowed with an excellent ADME profile^[1].

IC 50

PARP-1: 9 nM (Kd); PARP-2: 1390 nM (Kd)

NMS-P118 Preparation Products And Raw materials

Raw materials

Preparation Products

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NMS-P118 Suppliers

China 63 United States 8 Global 71

Shanghai Jinyin Biological Technology Co., Ltd

Tel: 021-20986266 18019349802
Email: 814527417@qq.com
Country: China
ProdList: 461
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Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
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Chembest Research Laboratories Limited

Tel: +86-21-20908456
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Email: sales@BioChemBest.com
Country: China
ProdList: 6003
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MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

Guangzhou Zhiya Chemdrugs Co.,Ltd

Tel: 18122150900
Fax: QQ:2869377561
Email: sculk28@163.com
Country: China
ProdList: 646
Advantage: 55

Shanghai Synchem Pharma Co., ltd

Tel: 21-619849051-1 18521059765
Email: synchempharma@aliyun.com
Country: China
ProdList: 6468
Advantage: 55

Hubei Chuangliankangcheng Pharmaceutical Co., Ltd.

Tel: 027-65388397 18164111589
Fax: 027-65388397
Email: 3321478047@qq.com
Country: China
ProdList: 2007
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
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Shanghai Changyan Chem & Tech Co., Ltd.

Tel: 021-20242659 18930833303
Fax: +86 (21) 2024-2659
Email: Sales@changyanchem.cn
Country: China
ProdList: 5001
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View Lastest Price from NMS-P118 manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: NMS-P118 1262417-51-5
Price: US $100.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 98%
Supply Ability: 10KG
Release date: 2021-09-13

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: NMS-P118 1262417-51-5
Price: US $100.00/Kg/Bag
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg
Release date: 2021-09-15

Career Henan Chemical Co

Product: NMS-P118 1262417-51-5
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-08

1262417-51-5, NMS-P118Related Search:

Dicyclohexylphenylphosphine

2-(1-(4,4-difluorocyclohexyl)piperidin-4-yl)-6-fluoro-3-oxoisoindoline-4-carboxamide

NMS-P118

2-[1-(4,4-Difluorocyclohexyl)-4-piperidinyl]-6-fluoro-2,3-dihydro-3-oxo-1H-isoindole-4-carboxamide

NMS-P118; NMS-P 118; NMS P118

2-[1-(4,4-difluorocyclohexyl)-piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide

CS-2354

1H-Isoindole-4-carboxamide, 2-[1-(4,4-difluorocyclohexyl)-4-piperidinyl]-6-fluoro-2,3-dihydro-3-oxo-

NMS-P118,inhibit,NMS P118,PARP,NMSP118,Inhibitor,poly ADP ribose polymerase,NMS-P-118

NMS-P118, 10 mM in DMSO

NMS-P118 ，S8363

1262417-51-5